Chaoshuang Xia | Biochemistry & Cell Biology

Title Postdoctoral Associate – Costello Lab
Education Northwest University, China, PhD
Office 670 Albany, 5th Floor
Email csxia@bu.edu
Phone (857) 204-9500
Area of Interest Development and application of mass spectral methods for determining the structures and functions of oligosaccharides and glycoconjugates

Chaoshuang Xia joined in Prof. Catherine E. Costello’s group at the Center for Biomedical Mass Spectrometry, Boston University School of Medicine in November 2019. His research focuses on applying mass spectrometry-based proteomics/ glycoproteomics/ glycomics techniques for exploring proteins on human cell surface facilitate SARS-COV-2 binding and infection to human cell, analyzing N-glycosylation of antibody, and on fundamental investigations of glycans for detailed glycan structural characterization.

Publications

1. Razie Amraei, Chaoshuang Xia, Judith Olejnik, Mitchell R White, Marc Napoleon, Saran Lotfollahzadeh, Blake Hauser, Aaron G. Schmidt, Vipul C Chitalia, Elke Mühlberger, Catherine E. Costello, and Nader Rahimi. Extracellular Vimentin is an Attachment Factor that Facilitates SARS-CoV-2 Entry into Human Endothelial Cells [J]. Proceedings of the National Academy of Sciences. 2022, In press.

2. Razie Amraei, Wenqing Yin, Marc A. Napoleon, Ellen L. Suder, Jacob Berrigan, Qing Zhao, Judith Olejnik, Kevin Brown Chandler, Chaoshuang Xia, Jared Feldman, Blake M. Hauser, Timothy M. Caradonna, Aaron G. Schmidt, Suryaram Gummuluru, Elke Mühlberger, Vipul Chitalia, Catherine E. Costello, and Nader Rahimi. CD209L/L-SIGN and CD209/DC-SIGN act as receptors for SARS-CoV-2 [J]. ACS Central Science 7.7 (2021): 1156-1165.

3. Yuanyuan Liu#, Chaoshuang Xia#, Zhiya Fan, Fenglong Jiao, Fangyuan Gao, Yuping Xie, Zhongmei He, Wanjun Zhang, Yangjun Zhang, Yehua Shen, Xiaohong Qian, and Weijie Qin. Novel Two-Dimensional MoS2–Ti4+ Nanomaterial for Efficient Enrichment of Phosphopeptides and Large-Scale Identification of Histidine Phosphorylation by Mass Spectrometry [J]. Analytical Chemistry, 2020, 92(19), 12801-12808.

4. Fenglong Jiao, Fangyuan Gao, Yuanyuan Liu, ZhiyaFan, Xiaochao Xiang, Chaoshuang Xia, Yayao Lv, Yuping Xie, Haihong Bai, Wanjun Zhang, Weijie Qin, and Xiaohong Qian. A facile “one-material” strategy for tandem enrichment of small extracellular vesicles phosphoproteome [J]. Talanta 223 (2021): 121776.

5. Yayao Lv, Hanqing Zhang, Guibin Wang, Chaoshuang Xia, Fangyuan Gao, Yangjun Zhang, Hailing Qiao, Yuping Xie, Weijie Qin, and Xiaohong Qian. A novel mass spectrometry method for the absolute quantification of several cytochrome P450 and uridine 5′-diphospho-glucuronosyltransferase enzymes in the human liver [J]. Analytical and bioanalytical chemistry 412.8 (2020): 1729-1740.

6. Hanqing Zhang, Yayao Lv, Juan Du, Wei Shao, Fenglong Jiao, Chaoshuang Xia, Fangyuan Gao, Qian Yu, Yuanyuan Liu, Wangjun Zhang, Yangjun Zhang, Weijie Qin, and Xiaohong Qian. A GSH Functionalized Magnetic Ultra-thin 2D-MoS2 nanocomposite for HILIC-based enrichment of N-glycopeptides from urine exosome and serum proteins [J]. Analytica chimica acta 1098 (2020): 181-189.

7. Fangyuan Gao, Fenglong Jiao, Chaoshuang Xia, Yang Zhao, Wantao Ying, Yuping Xie, Xiaoya Guan, Ming Tao, Yangjun Zhang, Weijie Qin, and Xiaohong Qian. A novel strategy for facile serum exosome isolation based on specific interactions between phospholipid bilayers and TiO2 [J]. Chemical science 10.6 (2019): 1579-1588.

8. Chaoshuang Xia, Fenglong Jiao, Fangyuan Gao, Heping Wang, Yayao Lv, Yehua Shen, Yangjun Zhang, and Xiaohong Qian. 2D-MoS2-Based Zwitterionic (ZIC)-HILIC Material for the Specific Enrichment of Glycopeptides [J]. Analytical Chemistry, 2018, 90(11): 6651-6659.

9. Chaoshuang Xia, Heping Wang, Fenglong Jiao, Fangyuan Gao, Qiong Wu, Yehua Shen, Yangjun Zhang, and Xiaohong Qian. Rational synthesis of MoS2-based immobilized trypsin for rapid and effective protein digestion [J]. Talanta 179 (2018): 393-400.

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