Alla Grishok, PhD

Associate Professor, Biochemistry & Cell Biology

Alla Grishok
617.358.4525
72 E. Concord St Silvio Conte (K)

Biography

Gene regulation by RNA and chromatin

Research in the Grishok laboratory utilizes the nematode Caenorhabditis elegans and focuses on new mechanisms of gene regulation by short RNAs and chromatin-modifying complexes. Model organisms, such as C. elegans, are best suited for basic science. Importantly, discoveries made in basic research have the potential to affect translational science and the biotech industry in often-unpredictable ways.

Other Positions

  • Co-Director, Genome Science Institute, Boston University
  • Graduate Faculty (Primary Mentor of Grad Students), Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

Education

  • University of Massachusetts Medical School, PhD
  • Kiev Taras Shevchenko University, BS

Publications

  • Published on 2/7/2024

    Sepulveda GP, Gushchanskaia ES, Mora-Martin A, Esse R, Nikorich I, Ceballos A, Kwan J, Blum BC, Dholiya P, Emili A, Perissi V, Cardamone MD, Grishok A. DOT1L stimulates MYC/Mondo transcription factor activity by promoting its degradation cycle on chromatin. bioRxiv. 2024 Feb 07. PMID: 38370658.

    Read at: PubMed
  • Published on 2/1/2023

    Liontis T, Verma K, Grishok A. DOT-1.1 (DOT1L) deficiency in C. elegans leads to small RNA-dependent gene activation. BBA Adv. 2023; 3:100080. PMID: 37082252.

    Read at: PubMed
  • Published on 12/3/2022

    Farley SJ, Grishok A, Zeldich E. Shaking up the silence: consequences of HMGN1 antagonizing PRC2 in the Down syndrome brain. Epigenetics Chromatin. 2022 Dec 03; 15(1):39. PMID: 36463299.

    Read at: PubMed
  • Published on 11/9/2021

    Ceballos A, Esse R, Grishok A. The proline-rich domain of MML-1 is biologically important but not required for localization to target promoters. MicroPubl Biol. 2021; 2021. PMID: 34778725.

    Read at: PubMed
  • Published on 9/29/2021

    Grishok A. Small RNAs Worm Up Transgenerational Epigenetics Research. DNA (Basel). 2021 Dec; 1(2):37-48. PMID: 34725653.

    Read at: PubMed
  • Published on 10/26/2020

    Lascarez-Lagunas LI, Herruzo E, Grishok A, San-Segundo PA, Colai√°covo MP. DOT-1.1-dependent H3K79 methylation promotes normal meiotic progression and meiotic checkpoint function in C. elegans. PLoS Genet. 2020 10; 16(10):e1009171. PMID: 33104701.

    Read at: PubMed
  • Published on 8/6/2020

    Esse R, Grishok A. Caenorhabditis elegans Deficient in DOT-1.1 Exhibit Increases in H3K9me2 at Enhancer and Certain RNAi-Regulated Regions. Cells. 2020 08 06; 9(8). PMID: 32781660.

    Read at: PubMed
  • Published on 7/12/2019

    Esse R, Gushchanskaia ES, Lord A, Grishok A. DOT1L complex suppresses transcription from enhancer elements and ectopic RNAi in Caenorhabditis elegans. RNA. 2019 10; 25(10):1259-1273. PMID: 31300558.

    Read at: PubMed
  • Published on 7/5/2019

    Zaarur N, Desevin K, Mackenzie J, Lord A, Grishok A, Kandror KV. ATGL-1 mediates the effect of dietary restriction and the insulin/IGF-1 signaling pathway on longevity in C. elegans. Mol Metab. 2019 09; 27:75-82. PMID: 31311719.

    Read at: PubMed
  • Published on 6/20/2019

    Gushchanskaia ES, Esse R, Ma Q, Lau NC, Grishok A. Interplay between small RNA pathways shapes chromatin landscapes in C. elegans. Nucleic Acids Res. 2019 06 20; 47(11):5603-5616. PMID: 31216042.

    Read at: PubMed

View 19 more publications: View full profile at BUMC

View all profiles