- Title Associate Professor
- Education PhD: University of Massachusetts
Postdoctoral Training, MIT
- Office K422
- Email email@example.com
- Phone 617-358-4525
- Area of Interest Gene regulation by RNA and chromatin
Research in my laboratory focuses on new mechanisms of gene regulation by short RNAs and chromatin-modifying complexes. We study how short RNAs affect transcription and higher order chromatin organization. Another focus of the laboratory is on the metazoan DOT1 methyltransferase complex. We discovered a mechanistic connection between DOT1 and O-GlcNAc as well as the regulation of the miRNA genes by the DOT1 complex. We have also implicated DOT1 in regulation of major signal transduction pathways during development. Our main research model is the nematode Caenorhabditis elegans, and we are interested in connecting our findings to the epigenetics of human disease.
Katia Gushchanskaia – Research Scientist
Gian Sepulveda – Graduate student
Cecere G, Hoersch S, O’Keeffe S, Sachidanandam R, Grishok A. Global effects of the CSR-1 RNA interference pathway on the transcriptional landscape. Nat Struct Mol Biol. 2014 Apr; 21(4):358-65. PMID: 24681887.
Kennedy LM, Grishok A. Neuronal migration is regulated by endogenous RNAi and chromatin-binding factor ZFP-1/AF10 in Caenorhabditis elegans. Genetics. 2014 May; 197(1):207-20. PMID: 24558261.
Cecere G, Grishok A. A nuclear perspective on RNAi pathways in metazoans. Biochim Biophys Acta. 2014 Mar; 1839(3):223-33. PMID: 24361586.
Kennedy LM, Pham SC, Grishok A. Nonautonomous regulation of neuronal migration by insulin signaling, DAF-16/FOXO, and PAK-1. Cell Rep. 2013 Sep 12; 4(5):996-1009. PMID: 23994474.
Cecere G, Hoersch S, Jensen MB, Dixit S, Grishok A. The ZFP-1(AF10)/DOT-1 complex opposes H2B ubiquitination to reduce Pol II transcription. Mol Cell. 2013 Jun 27; 50(6):894-907. PMID: 23806335.
Grishok A. Biology and Mechanisms of Short RNAs in Caenorhabditis elegans. Adv Genet. 2013; 83:1-69. PMID: 23890211.
Avgousti DC, Cecere G, Grishok A. The conserved PHD1-PHD2 domain of ZFP-1/AF10 is a discrete functional module essential for viability in Caenorhabditis elegans. Mol Cell Biol. 2013 Mar; 33(5):999-1015. PMID: 23263989.
Avgousti DC, Palani S, Sherman Y, Grishok A. CSR-1 RNAi pathway positively regulates histone expression in C. elegans. EMBO J. 2012 Oct 3; 31(19):3821-32. PMID: 22863779.
Cecere G, Zheng GX, Mansisidor AR, Klymko KE, Grishok A. Promoters recognized by forkhead proteins exist for individual 21U-RNAs. Mol Cell. 2012 Sep 14; 47(5):734-45. PMID: 22819322.
Grishok A. Endogenous RNAi and adaptation to environment in C. elegans. Worm. 2012 Apr 1; 1(2):129-33. PMID: 24058837.
Complete list can be found at BU Profiles
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