• Title Associate Professor
  • Education PhD: University of Massachusetts
    Postdoctoral Training, MIT
  • Office K422
  • Phone 617-358-4525
  • Area of Interest Gene regulation by RNA and chromatin

Research in my laboratory focuses on new mechanisms of gene regulation by short RNAs and chromatin-modifying complexes. We study how short RNAs affect transcription and higher order chromatin organization. Another focus of the laboratory is on the metazoan DOT1 methyltransferase complex. We discovered a mechanistic connection between DOT1 and O-GlcNAc as well as the regulation of the miRNA genes by the DOT1 complex. We have also implicated DOT1 in regulation of major signal transduction pathways during development. Our main research model is the nematode Caenorhabditis elegans, and we are interested in connecting our findings to the epigenetics of human disease.

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