Alla Grishok, PhD

Associate Professor, Boston University Chobanian & Avedisian School of Medicine

Biography

Gene regulation by RNA and chromatin

Research in the Grishok laboratory utilizes the nematode Caenorhabditis elegans and focuses on new mechanisms of gene regulation by short RNAs and chromatin-modifying complexes. Model organisms, such as C. elegans, are best suited for basic science. Importantly, discoveries made in basic research have the potential to affect translational science and the biotech industry in often-unpredictable ways.

Publications

  • Published 7/28/2026

    Sepulveda GP, Nawalaniec K, Nikorich I, Guschanskaia ES, Mora-Martin A, Esse R, Ceballos A, Xia C, Kwan J, Blum BC, Emili A, Cardamone MD, Perissi V, Costello CE, Grishok A. Proteolytic activation of c-MYC facilitated by DOT1L. Proc Natl Acad Sci U S A. 2026 Aug 04; 123(31):e2525603123. PMID: 42520114.

    Read at: PubMed

  • Published 1/8/2026

    Liontis T, Pannarale VT, Mansisidor AR, Pathiranage SK, Patel JY, Grishok A. Mutual regulation of spermatogenesis-specific Argonaute proteins and Insulin/IGF-1 signaling in aging control. EMBO Rep. 2026 Mar; 27(6):1437-1462. PMID: 41507348.

    Read at: PubMed

  • Published 2/7/2024

    Sepulveda GP, Gushchanskaia ES, Mora-Martin A, Esse R, Nikorich I, Ceballos A, Kwan J, Blum BC, Dholiya P, Emili A, Perissi V, Cardamone MD, Grishok A. DOT1L stimulates MYC/Mondo transcription factor activity by promoting its degradation cycle on chromatin. bioRxiv. 2024 Feb 07. PMID: 38370658.

    Read at: PubMed

  • Published 2/1/2023

    Liontis T, Verma K, Grishok A. DOT-1.1 (DOT1L) deficiency in C. elegans leads to small RNA-dependent gene activation. BBA Adv. 2023; 3:100080. PMID: 37082252.

    Read at: PubMed

  • Published 12/3/2022

    Farley SJ, Grishok A, Zeldich E. Shaking up the silence: consequences of HMGN1 antagonizing PRC2 in the Down syndrome brain. Epigenetics Chromatin. 2022 Dec 03; 15(1):39. PMID: 36463299.

    Read at: PubMed

View All 31 Publications:   View Full Profile in BUMC

Other Positions

  • Co-Director, Genome Science Institute
    Boston University
  • Graduate Medical Sciences Educator and Mentor (Primary Mentor of Graduate Students)
    Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

Websites

Education

  • University of Massachusetts Medical School, PhD
  • Kiev Taras Shevchenko University, BS

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