Xaralabos G. Varelas, PhD

Associate Professor, Biochemistry

Xaralabos Varelas
617.358.4575
72 E. Concord St Silvio Conte (K)

Biography

Research in the Varelas lab is focused on gaining insight into the molecular mechanisms by which cell fate is coordinated with cell proliferation and survival during animal development and disease. The lab is particularly interested in understanding the roles and regulation of the transcriptional regulators YAP and TAZ (YAP/TAZ), which are key effectors of the Hippo signaling pathway.

YAP/TAZ integrate cell polarity and mechanical cues with information relayed by growth factors and chemicals to direct essential processes and maintain organ homeostasis. The lab is incorporating genetic and biochemical approaches to define how YAP/TAZ control developmental events, and how dysregulation of YAP/TAZ activity contributes the etiology of various diseases, such as cancer.

Other Positions

  • Member, BU-BMC Cancer Center, Boston University
  • Member, Pulmonary Center, Boston University
  • Member, Center for Regenerative Medicine, Boston University
  • Member, Evans Center for Interdisciplinary Biomedical Research, Boston University
  • Graduate Faculty (Primary Mentor of Grad Students), Boston University School of Medicine, Graduate Medical Sciences
  • Member, Genome Science Institute, Boston University

Education

  • University of Alberta, PhD
  • McGill University, BSc

Classes Taught

  • GMSBI777
  • GMSFC703
  • GMSOH751

Publications

  • Published on 6/17/2020

    Dey A, Varelas X, Guan KL. Targeting the Hippo pathway in cancer, fibrosis, wound healing and regenerative medicine. Nat Rev Drug Discov. 2020 Jul; 19(7):480-494. PMID: 32555376.

    Read at: PubMed
  • Published on 1/31/2020

    Ikonomou L, Herriges MJ, Lewandowski SL, Marsland R, Villacorta-Martin C, Caballero IS, Frank DB, Sanghrajka RM, Dame K, Kandula MM, Hicks-Berthet J, Lawton ML, Christodoulou C, Fabian AJ, Kolaczyk E, Varelas X, Morrisey EE, Shannon JM, Mehta P, Kotton DN. The in vivo genetic program of murine primordial lung epithelial progenitors. Nat Commun. 2020 01 31; 11(1):635. PMID: 32005814.

    Read at: PubMed
  • Published on 1/13/2020

    Stampouloglou E, Cheng N, Federico A, Slaby E, Monti S, Szeto GL, Varelas X. Yap suppresses T-cell function and infiltration in the tumor microenvironment. PLoS Biol. 2020 01; 18(1):e3000591. PMID: 31929526.

    Read at: PubMed
  • Published on 11/15/2019

    Li A, Chapuy B, Varelas X, Sebastiani P, Monti S. Identification of candidate cancer drivers by integrative Epi-DNA and Gene Expression (iEDGE) data analysis. Sci Rep. 2019 11 15; 9(1):16904. PMID: 31729402.

    Read at: PubMed
  • Published on 10/30/2019

    Haak AJ, Kostallari E, Sicard D, Ligresti G, Choi KM, Caporarello N, Jones DL, Tan Q, Meridew J, Diaz Espinosa AM, Aravamudhan A, Maiers JL, Britt RD, Roden AC, Pabelick CM, Prakash YS, Nouraie SM, Li X, Zhang Y, Kass DJ, Lagares D, Tager AM, Varelas X, Shah VH, Tschumperlin DJ. Selective YAP/TAZ inhibition in fibroblasts via dopamine receptor D1 agonism reverses fibrosis. Sci Transl Med. 2019 10 30; 11(516). PMID: 31666402.

    Read at: PubMed
  • Published on 10/18/2019

    Jones DL, Haak AJ, Caporarello N, Choi KM, Ye Z, Yan H, Varelas X, Ordog T, Ligresti G, Tschumperlin DJ. TGFß-induced fibroblast activation requires persistent and targeted HDAC-mediated gene repression. J Cell Sci. 2019 10 18; 132(20). PMID: 31527052.

    Read at: PubMed
  • Published on 5/21/2019

    Stampouloglou E, Federico A, Slabi E, Monti S, Szeto GL, Varelas X. Yap suppresses T cell function and infiltration in the tumor microenvironment. 2019; (BioRvix).

    Read at: Custom
  • Published on 3/25/2019

    Kern JG, Varelas X. TAZ Forces Lateral Inhibition. Dev Cell. 2019 03 25; 48(6):748-750. PMID: 30913406.

    Read at: PubMed
  • Published on 2/19/2019

    Kartha VK, Sebastiani P, Kern JG, Zhang L, Varelas X, Monti S. CaDrA: A Computational Framework for Performing Candidate Driver Analyses Using Genomic Features. Front Genet. 2019; 10:121. PMID: 30838036.

    Read at: PubMed
  • Published on 1/1/2019

    Kingston NM, Tilston-Lunel AM, Hicks-Berthet J, Varelas X. Immunofluorescence Microscopy to Study Endogenous TAZ in Mammalian Cells. Methods Mol Biol. 2019; 1893:107-113. PMID: 30565129.

    Read at: PubMed

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