Xaralabos G. Varelas, PhD

Associate Professor, Biochemistry

Xaralabos Varelas
617.358.4575
72 E. Concord St Silvio Conte (K)

Biography

Research in the Varelas lab is focused on gaining insight into the molecular mechanisms by which cell fate is coordinated with cell proliferation and survival during animal development and disease. The lab is particularly interested in understanding the roles and regulation of the transcriptional regulators YAP and TAZ (YAP/TAZ), which are key effectors of the Hippo signaling pathway.

YAP/TAZ integrate cell polarity and mechanical cues with information relayed by growth factors and chemicals to direct essential processes and maintain organ homeostasis. The lab is incorporating genetic and biochemical approaches to define how YAP/TAZ control developmental events, and how dysregulation of YAP/TAZ activity contributes the etiology of various diseases, such as cancer.

Education

  • University of Alberta, PhD
  • McGill University, BSc

Publications

  • Published on 11/15/2019

    Li A, Chapuy B, Varelas X, Sebastiani P, Monti S. Identification of candidate cancer drivers by integrative Epi-DNA and Gene Expression (iEDGE) data analysis. Sci Rep. 2019 Nov 15; 9(1):16904. PMID: 31729402.

    Read at: PubMed
  • Published on 10/30/2019

    Haak AJ, Kostallari E, Sicard D, Ligresti G, Choi KM, Caporarello N, Jones DL, Tan Q, Meridew J, Diaz Espinosa AM, Aravamudhan A, Maiers JL, Britt RD, Roden AC, Pabelick CM, Prakash YS, Nouraie SM, Li X, Zhang Y, Kass DJ, Lagares D, Tager AM, Varelas X, Shah VH, Tschumperlin DJ. Selective YAP/TAZ inhibition in fibroblasts via dopamine receptor D1 agonism reverses fibrosis. Sci Transl Med. 2019 Oct 30; 11(516). PMID: 31666402.

    Read at: PubMed
  • Published on 10/18/2019

    Jones DL, Haak AJ, Caporarello N, Choi KM, Ye Z, Yan H, Varelas X, Ordog T, Ligresti G, Tschumperlin DJ. TGFß-induced fibroblast activation requires persistent and targeted HDAC-mediated gene repression. J Cell Sci. 2019 Oct 18; 132(20). PMID: 31527052.

    Read at: PubMed
  • Published on 5/21/2019

    Stampouloglou E, Federico A, Slabi E, Monti S, Szeto GL, Varelas X. Yap suppresses T cell function and infiltration in the tumor microenvironment. 2019; (BioRvix).

    Read at: Custom
  • Published on 3/25/2019

    Kern JG, Varelas X. TAZ Forces Lateral Inhibition. Dev Cell. 2019 03 25; 48(6):748-750. PMID: 30913406.

    Read at: PubMed
  • Published on 2/19/2019

    Kartha VK, Sebastiani P, Kern JG, Zhang L, Varelas X, Monti S. CaDrA: A Computational Framework for Performing Candidate Driver Analyses Using Genomic Features. Front Genet. 2019; 10:121. PMID: 30838036.

    Read at: PubMed
  • Published on 1/1/2019

    Kingston NM, Tilston-Lunel AM, Hicks-Berthet J, Varelas X. Immunofluorescence Microscopy to Study Endogenous TAZ in Mammalian Cells. Methods Mol Biol. 2019; 1893:107-113. PMID: 30565129.

    Read at: PubMed
  • Published on 10/18/2018

    Stampouloglou E, Varelas X. Phosphatidic Acid Signals via the Hippo Pathway. Mol Cell. 2018 10 18; 72(2):205-206. PMID: 30340020.

    Read at: PubMed
  • Published on 7/20/2018

    Kartha VK, Alamoud KA, Sadykov K, Nguyen BC, Laroche F, Feng H, Lee J, Pai SI, Varelas X, Egloff AM, Snyder-Cappione JE, Belkina AC, Bais MV, Monti S, Kukuruzinska MA. Functional and genomic analyses reveal therapeutic potential of targeting ß-catenin/CBP activity in head and neck cancer. Genome Med. 2018 07 20; 10(1):54. PMID: 30029671.

    Read at: PubMed
  • Published on 7/9/2018

    Meriin AB, Narayanan A, Meng L, Alexandrov I, Varelas X, Cissé II, Sherman MY. Hsp70-Bag3 complex is a hub for proteotoxicity-induced signaling that controls protein aggregation. Proc Natl Acad Sci U S A. 2018 07 24; 115(30):E7043-E7052. PMID: 29987014.

    Read at: PubMed

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