Xaralabos G. Varelas, PhD

Professor, Biochemistry

Xaralabos Varelas
617.358.4575
72 E. Concord St

Biography

Research in the Varelas lab is focused on gaining insight into the molecular mechanisms by which cell fate is coordinated with cell proliferation and survival during animal development and disease. The lab is particularly interested in understanding the roles and regulation of the transcriptional regulators YAP and TAZ (YAP/TAZ), which are key effectors of the Hippo signaling pathway.

YAP/TAZ integrate cell polarity and mechanical cues with information relayed by growth factors and chemicals to direct essential processes and maintain organ homeostasis. The lab is incorporating genetic and biochemical approaches to define how YAP/TAZ control developmental events, and how dysregulation of YAP/TAZ activity contributes the etiology of various diseases, such as cancer.

Other Positions

  • Member, BU-BMC Cancer Center, Boston University
  • Member, Pulmonary Center, Boston University
  • Member, Center for Regenerative Medicine, Boston University
  • Member, Evans Center for Interdisciplinary Biomedical Research, Boston University
  • Member, Genome Science Institute, Boston University
  • Graduate Faculty (Primary Mentor of Grad Students), Boston University School of Medicine, Graduate Medical Sciences

Education

  • University of Alberta, PhD
  • McGill University, BSc

Classes Taught

  • GMS BI777
  • GMS FC703
  • GMS OB800
  • GMS PA801
  • GMSOH751

Publications

  • Published on 7/11/2022

    Shirai T, Sekai M, Kozawa K, Sato N, Tanimura N, Kon S, Matsumoto T, Murakami T, Ito S, Tilston-Lunel A, Varelas X, Fujita Y. Basal extrusion of single-oncogenic mutant cells induces dome-like structures with altered microenvironments. Cancer Sci. 2022 Jul 11. PMID: 35816400.

    Read at: PubMed
  • Published on 7/1/2022

    Brosinsky P, Leister H, Cheng N, Varelas X, Visekruna A, Luu M. Verteporfin protects against Th17 cell-mediated EAE independently of YAP inhibition. Eur J Immunol. 2022 Jul 01. PMID: 35776890.

    Read at: PubMed
  • Published on 6/29/2022

    Vittoria MA, Kingston N, Kotynkova K, Xia E, Hong R, Huang L, McDonald S, Tilston-Lunel A, Darp R, Campbell JD, Lang D, Xu X, Ceol CJ, Varelas X, Ganem NJ. Inactivation of the Hippo tumor suppressor pathway promotes melanoma. Nat Commun. 2022 Jun 29; 13(1):3732. PMID: 35768444.

    Read at: PubMed
  • Published on 5/4/2022

    Alhousami T, Diny M, Ali F, Shin J, Kumar G, Kumar V, Campbell JD, Noonan V, Hanna GJ, Denis GV, Monti S, Kukuruzinska MA, Varelas X, Bais MV. Inhibition of LSD1 Attenuates Oral Cancer Development and Promotes Therapeutic Efficacy of Immune Checkpoint Blockade and YAP/TAZ Inhibition. Mol Cancer Res. 2022 May 04; 20(5):712-721. PMID: 35105672.

    Read at: PubMed
  • Published on 2/18/2022

    Rabhi N, Desevin K, Belkina AC, Tilston-Lunel A, Varelas X, Layne MD, Farmer SR. Obesity-induced senescent macrophages activate a fibrotic transcriptional program in adipocyte progenitors. Life Sci Alliance. 2022 05; 5(5). PMID: 35181634.

    Read at: PubMed
  • Published on 2/9/2022

    Na E, Allen E, Baird LA, Odom CV, Korkmaz FT, Shenoy AT, Matschulat AM, Jones MR, Kotton DN, Mizgerd JP, Varelas X, Traber KE, Quinton LJ. Epithelial LIF signaling limits apoptosis and lung injury during bacterial pneumonia. Am J Physiol Lung Cell Mol Physiol. 2022 Apr 01; 322(4):L550-L563. PMID: 35137631.

    Read at: PubMed
  • Published on 12/1/2021

    Baldan S, Meriin AB, Yaglom J, Alexandrov I, Varelas X, Xiao ZJ, Sherman MY. The Hsp70-Bag3 complex modulates the phosphorylation and nuclear translocation of Hippo pathway protein Yap. J Cell Sci. 2021 12 01; 134(23). PMID: 34761265.

    Read at: PubMed
  • Published on 8/31/2021

    Alysandratos KD, Russo SJ, Petcherski A, Taddeo EP, Acín-Pérez R, Villacorta-Martin C, Jean JC, Mulugeta S, Rodriguez LR, Blum BC, Hekman RM, Hix OT, Minakin K, Vedaie M, Kook S, Tilston-Lunel AM, Varelas X, Wambach JA, Cole FS, Hamvas A, Young LR, Liesa M, Emili A, Guttentag SH, Shirihai OS, Beers MF, Kotton DN. Patient-specific iPSCs carrying an SFTPC mutation reveal the intrinsic alveolar epithelial dysfunction at the inception of interstitial lung disease. Cell Rep. 2021 08 31; 36(9):109636. PMID: 34469722.

    Read at: PubMed
  • Published on 7/13/2021

    Hicks-Berthet J, Ning B, Federico A, Tilston-Lunel A, Matschulat A, Ai X, Lenburg ME, Beane J, Monti S, Varelas X. Yap/Taz inhibit goblet cell fate to maintain lung epithelial homeostasis. Cell Rep. 2021 07 13; 36(2):109347. PMID: 34260916.

    Read at: PubMed
  • Published on 5/27/2021

    Dela Cruz A, Kartha V, Tilston-Lunel A, Mi R, Reynolds TL, Mingueneau M, Monti S, Jensen JL, Skarstein K, Varelas X, Kukuruzinska MA. Gene expression alterations in salivary gland epithelia of Sjögren's syndrome patients are associated with clinical and histopathological manifestations. Sci Rep. 2021 05 27; 11(1):11154. PMID: 34045583.

    Read at: PubMed

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