My research focuses on the relationship between innate and adaptive immunity, and how components of the two discrete systems interact to generate long-lasting protective immune responses. One area of focus has been on the role of IgM antibodies as efficient bridges of innate and adaptive immunity. IgM antibodies serve to concentrate antigens into secondary lymphoid organs, accelerating the production of protective immune responses along with affinity matured antibodies. IgM also contributes to preventing pathogens from initially localizing into vital organs. The innate functions of IgM can be attributed, at least in part, to its ability to concentrate immune complexes in the foci of the spleen, where innate B cells in the marginal zones traffic the complexes to follicular dendritic cells, stromal elements that promote efficient germinal center formation. These functions require native organization around the marginal sinuses for efficient adjuvant effects of IgM.
The laboratory also focuses on the immune consequences of infection with highly pathogenic hemorrhagic fever viruses, including filoviruses. Patients infected with these viruses often fail to make adaptive immune responses and succumb to infection. While this is often attributed to dysfunctional innate immune responses, the nature of the defects in immune responses to these viruses is poorly understood. We are interested in in the very early immune responses to these viruses, in order to map how they affect the ability of infected animals to initiate adaptive immune responses, and identify the components of infection that lead to abnormal cytokine responses that characterize infection with these viruses.
- Professor, Microbiology, Boston University School of Medicine
- Chair, Microbiology, Boston University School of Medicine
- Mentor for Graduate Medical Students, Boston University School of Medicine, Division of Graduate Medical Sciences
- Duke University, PhD
- Duke University, BS
- Published on 6/26/2017
Schultz MJ, Isern S, Michael SF, Corley RB, Connor JH, Frydman HM. Variable Inhibition of Zika Virus Replication by Different Wolbachia Strains in Mosquito Cell Cultures. J Virol. 2017 Jul 15; 91(14). PMID: 28446677.
- Published on 8/1/2011
Olejnik J, Ryabchikova E, Corley RB, Mühlberger E. Intracellular events and cell fate in filovirus infection. Viruses. 2011 Aug; 3(8):1501-31. PMID: 21927676.
- Published on 7/31/2009
Yasuda K, Richez C, Uccellini MB, Richards RJ, Bonegio RG, Akira S, Monestier M, Corley RB, Viglianti GA, Marshak-Rothstein A, Rifkin IR. Requirement for DNA CpG content in TLR9-dependent dendritic cell activation induced by DNA-containing immune complexes. J Immunol. 2009 Sep 1; 183(5):3109-17. PMID: 19648272.
- Published on 12/1/2007
Busconi L, Bauer JW, Tumang JR, Laws A, Perkins-Mesires K, Tabor AS, Lau C, Corley RB, Rothstein TL, Lund FE, Behrens TW, Marshak-Rothstein A. Functional outcome of B cell activation by chromatin immune complex engagement of the B cell receptor and TLR9. J Immunol. 2007 Dec 1; 179(11):7397-405. PMID: 18025183.
- Published on 7/1/2005
Corley RB, Morehouse EM, Ferguson AR. IgM accelerates affinity maturation. Scand J Immunol. 2005 Jul; 62 Suppl 1:55-61. PMID: 15953185.
- Published on 4/18/2005
Ferguson AR, Corley RB. Accumulation of marginal zone B cells and accelerated loss of follicular dendritic cells in NF-kappaB p50-deficient mice. BMC Immunol. 2005; 6:8. PMID: 15836790.
- Published on 1/15/2005
Doerre S, Mesires KP, Daley KM, McCarty T, Knoetig S, Corley RB. Reductions in I kappa B epsilon and changes in NF-kappa B activity during B lymphocyte differentiation. J Immunol. 2005 Jan 15; 174(2):983-91. PMID: 15634922.
- Published on 1/1/2005
Corley RB. A Guide to Methods in the Biomedical Sciences. Springer Science+Business Media, Inc. New York. 2005.
- Published on 12/1/2004
Youd ME, Luus L, Corley RB. IgM monomers accelerate disease manifestations in autoimmune-prone Fas-deficient mice. J Autoimmun. 2004 Dec; 23(4):333-43. PMID: 15571927.
- Published on 8/23/2004
Ferguson AR, Youd ME, Corley RB. Marginal zone B cells transport and deposit IgM-containing immune complexes onto follicular dendritic cells. Int Immunol. 2004 Oct; 16(10):1411-22. PMID: 15326094.
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