Louis C. Gerstenfeld, PhD

Professor, Orthopaedic Surgery

Louis Gerstenfeld
72 E. Concord St Housman (R)


My expertise is in the area of skeletal tissue biology. I have studied skeletal biology for more than 30 years and have broad knowledge across many areas in the field, including metabolic bone disease and orthopedic-related diseases. I have carried out numerous pre-clinical assessments of pharmacological compounds as they relate to safety and efficacy in the treatment of fracture and osteoporosis. I have expertise in skeletal tissue structure and the histomorphometric assessment of skeletal tissues, skeletal tissue cell biology and skeletal tissue transcriptomics. I was among the first four labs in the United States to develop in vitro osteoblast cultures and helped to establish the standard time dependent sequence of osteogenic differentiation in vitro. My laboratory also was one of four to initially isolate the proteins and clone the major extracellular matrix proteins of bone. I have served on the NIH IRG for Orthopedics, NASA and DOD review panels for orthopedic related research and worked on Special Emphasis Review Panels for the FDA. My current work focuses on relating genomic variants that define human bone quality to transcriptomic phenotypes of ostoeblasts and osteoclasts. Other studies in laboratory are focused on developing serum based diagnostics to follow the progression of fracture healing and define delayed and failed healing in humans.

Other Positions

  • Research Professor, Biochemistry, Boston University School of Medicine
  • Professor, Pulmonary, Allergy, Sleep & Critical Care Medicine, Medicine, Boston University School of Medicine
  • Member, Center for Regenerative Medicine, Boston University
  • Member, Evans Center for Interdisciplinary Biomedical Research, Boston University
  • Graduate Faculty (Primary Mentor of Grad Students), Boston University School of Medicine, Graduate Medical Sciences


  • Boston University School of Medicine, PhD
  • Pennsylvania State University, BA
  • Pennsylvania State University, BS

Classes Taught

  • GMSBR700
  • GMSMM730
  • SDM OR 807


  • Published on 6/17/2021

    Cui Q, Aksu C, Ay B, Remillard CE, Plagge A, Gardezi M, Dunlap M, Gerstenfeld LC, He Q, Bastepe M. Maternal GNAS Contributes to the Extra-Large G Protein a-Subunit (XLas) Expression in a Cell Type-Specific Manner. Front Genet. 2021; 12:680537. PMID: 34220953.

    Read at: PubMed
  • Published on 5/1/2021

    Uda Y, Spatz JM, Hussein A, Garcia JH, Lai F, Dedic C, Fulzele K, Dougherty S, Eberle M, Adamson C, Misener L, Gerstenfeld L, Divieti Pajevic P. Global transcriptomic analysis of a murine osteocytic cell line subjected to spaceflight. FASEB J. 2021 05; 35(5):e21578. PMID: 33835498.

    Read at: PubMed
  • Published on 1/1/2021

    Morgan EF, Giacomo A, Gerstenfeld LC. Overview of Skeletal Repair (Fracture Healing and Its Assessment). Methods Mol Biol. 2021; 2230:17-37. PMID: 33197006.

    Read at: PubMed
  • Published on 1/1/2021

    De Giacomo A, Morgan EF, Gerstenfeld LC. Generation of Closed Transverse Fractures in Small Animals. Methods Mol Biol. 2021; 2230:63-73. PMID: 33197008.

    Read at: PubMed
  • Published on 11/19/2020

    Tashkandi MM, Alsaqer SF, Alhousami T, Ali F, Wu YC, Shin J, Mehra P, Wolford LM, Gerstenfeld LC, Goldring MB, Bais MV. LOXL2 promotes aggrecan and gender-specific anabolic differences to TMJ cartilage. Sci Rep. 2020 11 19; 10(1):20179. PMID: 33214607.

    Read at: PubMed
  • Published on 6/16/2020

    Montagna G, Cristofaro F, Fassina L, Bruni G, Cucca L, Kochen A, Divieti Pajevic P, Bragdon B, Visai L, Gerstenfeld L. An in vivo Comparison Study Between Strontium Nanoparticles and rhBMP2. Front Bioeng Biotechnol. 2020; 8:499. PMID: 32612980.

    Read at: PubMed
  • Published on 6/1/2020

    Reahl GB, Gerstenfeld L, Kain M. Epidemiology, Clinical Assessments, and Current Treatments of Nonunions. Curr Osteoporos Rep. 2020 06; 18(3):157-168. PMID: 32318988.

    Read at: PubMed
  • Published on 6/1/2020

    Wu J, Gupta M, Hussein AI, Gerstenfeld L. Bayesian modeling of factorial time-course data with applications to a bone aging gene expression study. J Appl Stat. 2021; 48(10):1730-1754. PMID: 34295011.

    Read at: PubMed
  • Published on 3/1/2019

    Lu D, Tripodis Y, Gerstenfeld LC, Demissie S. Clustering of temporal gene expression data with mixtures of mixed effects models with a penalized likelihood. Bioinformatics. 2019 03 01; 35(5):778-786. PMID: 30101356.

    Read at: PubMed
  • Published on 9/13/2018

    Noguchi T, Hussein AI, Horowitz N, Carroll D, Gower AC, Demissie S, Gerstenfeld LC. Hypophosphatemia Regulates Molecular Mechanisms of Circadian Rhythm. Sci Rep. 2018 09 13; 8(1):13756. PMID: 30213970.

    Read at: PubMed

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