Katya Ravid, DSc

Professor, Medicine

Katya Ravid
(617) 638-5053
700 Albany St Ctr for Adv Biomed Res

Biography

Platelet aggregation plays a central role in thrombosis and hemostasis, which are central to vascular disease. In the platelet lineage, the early committed cells undergo a unique cell cycle leading to the formation of polyploid megakaryocytes prior to their fragmentation into platelets. Our research focuses on mechanisms that regulate lineage commitment and the subsequent steps of cellular maturation of bone marrow cells into polyploid megakaryocytes. We reported that polyploidy also develops in aging vascular cells, and in other cell types under stress, and mechanisms of control of polyploidy and its relevance to disease states are investigated. An ongoing related project involves the molecular characterization of platelet and vascular adenosine receptors, and exploration of their role in cellular function and lineage development. The systems used include primary bone marrow cultures, as well as transgenic and knock out mouse models.

Other Positions

  • Professor, Biochemistry, Boston University School of Medicine
  • Director, Evans Center for Interdisciplinary Biomedical Research, Medicine, Boston University School of Medicine
  • Director, BU Interdisciplinary Biomedical Research Office, Boston University
  • Director, Master of Science Program in Biomedical Research, Medicine, Boston University School of Medicine
  • Mentor for Graduate Medical Students, Boston University School of Medicine, Division of Graduate Medical Sciences
  • Center Faculty Member, Cardiovascular Institute (Whitaker), Boston University School of Medicine

Education

  • Technion - Israel Institute of Technology, PhD
  • Technion - Israel Institute of Technology, BSc
  • Technion - Israel Institute of Technology, DSc

Publications

  • Published on 10/1/2017

    Ravid K, Seta F, Center D, Waters G, Coleman D. Catalyzing Interdisciplinary Research and Training: Initial Outcomes and Evolution of the Affinity Research Collaboratives Model. Acad Med. 2017 Oct; 92(10):1399-1405. PMID: 28445220.

    Read at: PubMed
  • Published on 7/15/2017

    Gordon CE, Chitalia VC, Sloan JM, Salant DJ, Coleman DL, Quillen K, Ravid K, Francis JM. Thrombotic Microangiopathy: A Multidisciplinary Team Approach. Am J Kidney Dis. 2017 Nov; 70(5):715-721. PMID: 28720207.

    Read at: PubMed
  • Published on 6/7/2017

    Abbonante V, Chitalia V, Rosti V, Leiva O, Matsuura S, Balduini A, Ravid K. Upregulation of lysyl oxidase and adhesion to collagen of human megakaryocytes and platelets in primary myelofibrosis. Blood. 2017 Aug 10; 130(6):829-831. PMID: 28592432.

    Read at: PubMed
  • Published on 6/1/2017

    Grenz A, Bauerle JD, Dalton JH, Ridyard D, Badulak A, Tak E, McNamee EN, Clambey E, Moldovan R, Reyes G, Klawitter J, Ambler K, Magee K, Christians U, Brodsky KS, Ravid K, Choi DS, Wen J, Lukashev D, Blackburn MR, Osswald H, Coe IR, Nürnberg B, Haase VH, Xia Y, Sitkovsky M, Eltzschig HK. Equilibrative nucleoside transporter 1 (ENT1) regulates postischemic blood flow during acute kidney injury in mice. J Clin Invest. 2017 Jun 01; 127(6):2438. PMID: 28569735.

    Read at: PubMed
  • Published on 4/14/2017

    Abbonante V, Di Buduo CA, Gruppi C, De Maria C, Spedden E, De Acutis A, Staii C, Raspanti M, Vozzi G, Kaplan DL, Moccia F, Ravid K, Balduini A. A new path to platelet production through matrix sensing. Haematologica. 2017 Jul; 102(7):1150-1160. PMID: 28411253.

    Read at: PubMed
  • Published on 2/3/2017

    Leiva O, Ng SK, Chitalia S, Balduini A, Matsuura S, Ravid K. The role of the extracellular matrix in primary myelofibrosis. Blood Cancer J. 2017 Feb 03; 7(2):e525. PMID: 28157219.

    Read at: PubMed
  • Published on 11/22/2016

    Lucero HA, Patterson S, Matsuura S, Ravid K. Quantitative histological image analyses of reticulin fibers in a myelofibrotic mouse. J Biol Methods. 2016; 3(4). PMID: 28008415.

    Read at: PubMed
  • Published on 11/11/2016

    Matsuura S, Patterson S, Lucero H, Leiva O, Grant AK, Herrera VL, Ravid K. In vivo magnetic resonance imaging of a mouse model of myelofibrosis. Blood Cancer J. 2016 Nov 11; 6(11):e497. PMID: 27834941.

    Read at: PubMed
  • Published on 5/17/2016

    Sun Y, Hu W, Yu X, Liu Z, Tarran R, Ravid K, Huang P. Actinin-1 binds to the C-terminus of A2B adenosine receptor (A2BAR) and enhances A2BAR cell-surface expression. Biochem J. 2016 Jul 15; 473(14):2179-86. PMID: 27208173.

    Read at: PubMed
  • Published on 1/11/2016

    Matsuura S, Mi R, Koupenova M, Eliades A, Patterson S, Toselli P, Thon J, Italiano JE, Trackman PC, Papadantonakis N, Ravid K. Lysyl oxidase is associated with increased thrombosis and platelet reactivity. Blood. 2016 Mar 17; 127(11):1493-501. PMID: 26755713.

    Read at: PubMed

View 131 more publications: View full profile at BUMC

View all profiles