Platelet aggregation plays a central role in thrombosis and hemostasis, which are central to vascular disease. In the platelet lineage, the early committed cells undergo a unique cell cycle leading to the formation of polyploid megakaryocytes prior to their fragmentation into platelets. Our research focuses on mechanisms that regulate lineage commitment and the subsequent steps of cellular maturation of bone marrow cells into polyploid megakaryocytes. We reported that polyploidy also develops in aging vascular cells, and in other cell types under stress, and mechanisms of control of polyploidy and its relevance to disease states are investigated. An ongoing related project involves the molecular characterization of platelet and vascular adenosine receptors, and exploration of their role in cellular function and lineage development. The systems used include primary bone marrow cultures, as well as transgenic and knock out mouse models.
- Professor, Biochemistry, Boston University School of Medicine
- Director, Evans Center for Interdisciplinary Biomedical Research, Medicine, Boston University School of Medicine
- Director, BU Interdisciplinary Biomedical Research Office, Boston University
- Director, Master of Science Program in Biomedical Research, Medicine, Boston University School of Medicine
- Mentor for Graduate Medical Students, Boston University School of Medicine, Graduate Medical Sciences
- Center Faculty Member, Cardiovascular Institute (Whitaker), Boston University School of Medicine
- Technion - Israel Institute of Technology, PhD
- Technion - Israel Institute of Technology, BSc
- Technion - Israel Institute of Technology, DSc
- Published on 12/10/2018
Li HM, Jang JH, Jung JS, Shin J, Park CO, Kim YJ, Ahn WG, Nam JS, Hong CW, Lee J, Jung YJ, Chen JF, Ravid K, Lee HT, Huh WK, Kabarowski JH, Song DK. G2A Protects Mice against Sepsis by Modulating Kupffer Cell Activation: Cooperativity with Adenosine Receptor 2b. J Immunol. 2019 Jan 15; 202(2):527-538. PMID: 30530591.
- Published on 10/2/2018
Artuz CM, Knights AJ, Funnell APW, Gonda TJ, Ravid K, Pearson RCM, Quinlan KGR, Crossley M. Partial reprogramming of heterologous cells by defined factors to generate megakaryocyte lineage-restricted biomolecules. Biotechnol Rep (Amst). 2018 Dec; 20:e00285. PMID: 30364711.
- Published on 1/30/2018
Koupenova M, Ravid K. Biology of Platelet Purinergic Receptors and Implications for Platelet Heterogeneity. Front Pharmacol. 2018; 9:37. PMID: 29441021.
- Published on 1/17/2018
Kolachalama VB, Shashar M, Alousi F, Shivanna S, Rijal K, Belghasem ME, Walker J, Matsuura S, Chang GH, Gibson CM, Dember LM, Francis JM, Ravid K, Chitalia VC. Uremic Solute-Aryl Hydrocarbon Receptor-Tissue Factor Axis Associates with Thrombosis after Vascular Injury in Humans. J Am Soc Nephrol. 2018 Mar; 29(3):1063-1072. PMID: 29343519.
- Published on 1/12/2018
Leiva O, Leon C, Kah Ng S, Mangin P, Gachet C, Ravid K. The role of extracellular matrix stiffness in megakaryocyte and platelet development and function. Am J Hematol. 2018 03; 93(3):430-441. PMID: 29247535.
- Published on 11/22/2017
Shashar M, Belghasem ME, Matsuura S, Walker J, Richards S, Alousi F, Rijal K, Kolachalama VB, Balcells M, Odagi M, Nagasawa K, Henderson JM, Gautam A, Rushmore R, Francis J, Kirchhofer D, Kolandaivelu K, Sherr DH, Edelman ER, Ravid K, Chitalia VC. Targeting STUB1-tissue factor axis normalizes hyperthrombotic uremic phenotype without increasing bleeding risk. Sci Transl Med. 2017 Nov 22; 9(417). PMID: 29167396.
- Published on 10/1/2017
Ravid K, Seta F, Center D, Waters G, Coleman D. Catalyzing Interdisciplinary Research and Training: Initial Outcomes and Evolution of the Affinity Research Collaboratives Model. Acad Med. 2017 Oct; 92(10):1399-1405. PMID: 28445220.
- Published on 7/31/2017
Zhang A, Rijal K, Ng SK, Ravid K, Chitalia V. A mass spectrometric method for quantification of tryptophan-derived uremic solutes in human serum. J Biol Methods. 2017; 4(3). PMID: 29707597.
- Published on 7/15/2017
Gordon CE, Chitalia VC, Sloan JM, Salant DJ, Coleman DL, Quillen K, Ravid K, Francis JM. Thrombotic Microangiopathy: A Multidisciplinary Team Approach. Am J Kidney Dis. 2017 Nov; 70(5):715-721. PMID: 28720207.
- Published on 6/7/2017
Abbonante V, Chitalia V, Rosti V, Leiva O, Matsuura S, Balduini A, Ravid K. Upregulation of lysyl oxidase and adhesion to collagen of human megakaryocytes and platelets in primary myelofibrosis. Blood. 2017 08 10; 130(6):829-831. PMID: 28592432.
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