Jude T. Deeney, PhD

Assistant Professor, Boston University Chobanian & Avedisian School of Medicine

Biography

Dr. Deeney's research is designed to discern the nutrient-derived metabolic signals leading to glucose- and fatty acid (FA)-induced insulin exocytosis from the pancreatic ß-cell. FA acutely stimulates glucose-induced insulin secretion (GSIS) while chronic exposure to elevated FA and glucose can result in glucolipotoxicity (GLT) with basal hypersecretion and inhibition of GSIS. Despite the adverse effects of chronic exposure, FA is known to be required for normal exocytosis from the ß-cell. Deciphering the dual effects of FA on GSIS will lead to the possible development of therapies that would reduce the inhibitory effects while sparing the stimulatory effects of FA on the ß-cell. Studies in his laboratory are aimed at identifying the lipids or lipid classes involved in enhancing and suppressing GSIS and assessing their effects on lipid-modulated or modulating proteins.

Publications

  • Published 6/25/2025

    Uçar N, Pickering RT, Mueller PM, Deeney JT, Morales Suárez-Varela M, Soriano JM, Holick MF. Vitamin D3, 25-Hydroxyvitamin D3, and 1,25-Dihydroxyvitamin D3 Uptake in Cultured Human Mature Adipocytes. Nutrients. 2025 Jun 25; 17(13). PMID: 40647210.

    Read at: PubMed

  • Published 1/1/2025

    Uçar N, Deeney JT, Pickering RT, Fan TY, Loo R, Mueller PM, Holick MF. Interaction of Vitamin D-BODIPY With Fat Cells and the Link to Obesity-associated Vitamin D Deficiency. Anticancer Res. 2025 Jan; 45(1):55-63. PMID: 39740852.

    Read at: PubMed

  • Published 9/28/2023

    Yuan M, Hu FB, Li Y, Cabral HJ, Das SK, Deeney JT, Zhou X, Paik JM, Moore LL. Types of dairy foods and risk of fragility fracture in the prospective Nurses' Health Study cohort. Am J Clin Nutr. 2023 Dec; 118(6):1172-1181. PMID: 37777015.

    Read at: PubMed

  • Published 8/10/2023

    Zheng A, Huang N, Bean D, Rayapaneni S, Deeney J, Sagar M, Hamilton JA. Resolvin E1 heals injured cardiomyocytes: Therapeutic implications and H-FABP as a readout for cardiovascular disease & systemic inflammation. Prostaglandins Leukot Essent Fatty Acids. 2023 Oct; 197:102586. PMID: 37604082.

    Read at: PubMed

  • Published 1/6/2023

    Yuan M, Hu FB, Li Y, Cabral HJ, Das SK, Deeney JT, Moore LL. Dairy Foods, Weight Change, and Risk of Obesity During the Menopausal Transition. J Nutr. 2023 Mar; 153(3):811-819. PMID: 36931753.

    Read at: PubMed

View All 67 Publications:   View Full Profile in BUMC

Other Positions

  • Member, Evans Center for Interdisciplinary Biomedical Research
    Boston University
  • Associate Member, Boston Nutrition Obesity Research Center
    Boston University Medical Center
  • Graduate Faculty (Primary Mentor of Grad Students)
    Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

Websites

Education

  • Karolinska Institutet, PhD
  • Virginia Polytechnic Institute and State University, MS
  • Saint Joseph College, BS

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