Jessica L. Fetterman, PhD

Assistant Professor, Medicine

617.358.7544
75 E. Newton St Evans Building

Biography

Dr. Fetterman is a basic and translational scientist studying the intersections of mitochondrial physiology, mitochondrial genetic epidemiology, and cardiovascular disease. Her work focuses on the contribution of mitochondrial genetic variation and abnormalities to cardiovascular disease in the presence of risk factors, including tobacco product use and diabetes.

Using bioinformatics methods, Dr. Fetterman discovered that several select mitochondrial genetic variants are associated with non-invasive measures of vascular function within the Framingham Heart Study (FHS). Additionally, she has applied similar methodology to select mitochondrial single variant data within Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) to determine the associations of select mitochondrial genetic variants with cardiometabolic measures in collaboration with members of the mitochondrial genetics working group. Recently, Dr. Fetterman was awarded the competitive Trans-Omics Precision Medicine (TOPMed) Analytical Support Award for early career investigators to perform comprehensive bioinformatic annotation of the mitochondrial genetic variants within the TOPMed cohorts.

Dr. Fetterman also conducts research on the impact of new and emerging tobacco products on the vasculature, particularly studies designed to inform tobacco product regulation. Some of her recent work demonstrated that tobacco product flavoring additives induce vascular endothelial dysfunction, an early indicator of cardiovascular injury. She serves as an Associate Director of Education and Training within American Heart Association Tobacco Regulation and Addiction Center. Additionally, she is the Director for the Boston University Tobacco Regulatory Science Affinity Research Collaborative, which is designed to bring together multi-disciplinary teams of scientists within Boston University to increase our understanding of tobacco product use patterns and the impact of new and emerging tobacco products on human health and disease.

Other Positions

  • Investigator, Framingham Heart Study
  • Member, Whitaker Cardiovascular Institute, Boston University
  • Member, Evans Center for Interdisciplinary Biomedical Research, Boston University

Education

  • University of Alabama at Birmingham, PhD
  • Ohio Wesleyan University, BA

Publications

  • Published on 2/2/2022

    Liu C, Fetterman JL, Sun X, Yan K, Liu P, Luo Y, Ding J, Zhu J, Levy D. Comparison of mitochondrial DNA sequences from whole blood and lymphoblastoid cell lines. Sci Rep. 2022 02 02; 12(1):1801. PMID: 35110616.

    Read at: PubMed
  • Published on 1/28/2022

    Xie W, Tackett AP, Berlowitz JB, Harlow AF, Kathuria H, Galiatsatos P, Fetterman JL, Cho J, Blaha MJ, Hamburg NM, Robertson RM, DeFilippis AP, Hall ME, Bhatnagar A, Benjamin EJ, Stokes AC. Association of Electronic Cigarette Use with Respiratory Symptom Development among US Young Adults. Am J Respir Crit Care Med. 2022 Jan 28. PMID: 35089853.

    Read at: PubMed
  • Published on 1/20/2022

    Wang Y, Xu YA, Wu J, Kim HM, Fetterman JL, Hong T, McLaughlin ML. Moralization of E-cigarette Use and Regulation: A Mixed-Method Computational Analysis of Opinion Polarization. Health Commun. 2022 Jan 20; 1-11. PMID: 35057690.

    Read at: PubMed
  • Published on 1/6/2022

    Rezk-Hanna M, Warda US, Stokes AC, Fetterman J, Li J, Macey PM, Darawad M, Song Y, Ben Taleb Z, Brecht ML, Benowitz NL. Associations of Smokeless Tobacco Use With Cardiovascular Disease Risk: Insights From the Population Assessment of Tobacco and Health Study. Nicotine Tob Res. 2022 Jan 06. PMID: 34999825.

    Read at: PubMed
  • Published on 1/4/2022

    Ajayi TB, Childs E, Di Frances Remein C, Forbush LR, Ragasa JB, Fetterman JL, Hirsch GA, Benjamin EJ. Fostering Tobacco Regulatory Team Science through a multisite, virtual fellowship program for early-career researchers. J Clin Transl Sci. 2022; 6(1):e14. PMID: 35211340.

    Read at: PubMed
  • Published on 10/22/2021

    Moreira JD, Gopal DM, Kotton DN, Fetterman JL. Gaining Insight into Mitochondrial Genetic Variation and Downstream Pathophysiology: What Can i(PSCs) Do? Genes (Basel). 2021 10 22; 12(11). PMID: 34828274.

    Read at: PubMed
  • Published on 7/21/2021

    Liu C, Fetterman JL, Qian Y, Sun X, Blackwell TW, Pitsillides A, Cade BE, Wang H, Raffield LM, Lange LA, Anugu P, Abecasis G, Adrienne Cupples L, Redline S, Correa A, Vasan RS, Wilson JG, Ding J, Levy D. Presence and transmission of mitochondrial heteroplasmic mutations in human populations of European and African ancestry. Mitochondrion. 2021 09; 60:33-42. PMID: 34303007.

    Read at: PubMed
  • Published on 5/24/2021

    Stokes AC, Wilson AE, Lundberg DJ, Xie W, Berry KM, Fetterman JL, Harlow AF, Cozier YC, Barrington-Trimis JL, Sterling KL, Benjamin EJ, Blaha MJ, Hamburg NM, Bhatnagar A, Robertson RM. Racial/Ethnic Differences in Associations of Non-cigarette Tobacco Product Use With Subsequent Initiation of Cigarettes in US Youths. Nicotine Tob Res. 2021 05 24; 23(6):900-908. PMID: 32948872.

    Read at: PubMed
  • Published on 5/20/2021

    Majid S, Keith RJ, Fetterman JL, Weisbrod RM, Nystoriak J, Wilson T, Stokes AC, Blaha MJ, Srivastava S, Robertson RM, Bhatnagar A, Hamburg NM. Lipid profiles in users of combustible and electronic cigarettes. Vasc Med. 2021 10; 26(5):483-488. PMID: 34013801.

    Read at: PubMed
  • Published on 1/21/2021

    Harlow AF, Fetterman JL, Ross CS, Robertson RM, Bhatnagar A, Benjamin EJ, Stokes AC. Association of device type, flavours and vaping behaviour with tobacco product transitions among adult electronic cigarette users in the USA. Tob Control. 2021 Jan 21. PMID: 33479031.

    Read at: PubMed

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