James W. Holsapple, MD

Chair , Boston University Chobanian & Avedisian School of Medicine

Biography

James Holsapple, MD, has been an associate professor of neurosurgery and pediatrics at BMC/BUSM since 2009. Holsapple received his undergraduate degree from Drake University, Magna Cum Laude, and his MD from University of Kansas School of Medicine. He completed an internal medicine internship at St. Luke’s Hospital, Kansas City, Missouri and a general surgery internship and neurological surgery residency at Upstate Medical University (SUNY), where he was also a NRSA Research Fellow in the Departments of Neurological Surgery and Physiology. He then joined the faculty and was promoted to Associate Professor of Neurological Surgery and Pediatrics.

A resident of South Boston, Holsapple is a member of the New England Neurological Society, the Congress of Neurological Surgeons and the American Association of Neurological Surgeons. The author of numerous papers, peer-reviewed articles, chapters and case reports, his research interests include primate visual and motor processing, human brain tumor management and biology. Holsapple’s clinical interests include adult intracranial tumors, vascular surgery and pediatric neurosurgery.

Publications

  • Published 2/17/2026

    Ramirez-Velandia F, Piazzi-Tavares F, Brandle MA, Vasconcellos FN, McNeil EP, Nadew T, Dasenbrock HH, Holsapple JW. Unusual complication of intrathecal methotrexate via ommaya reservoir in diffuse large B-cell lymphoma with central nervous system involvement. Brain Circ. 2026; 12(1):95-102. PMID: 41815820.

    Read at: PubMed

  • Published 12/9/2025

    Arunachalam Sakthiyendran N, Gonzalez-Salido J, Perkins T, Enriquez-Marulanda A, Dasenbrock H, Holsapple J. The subdural membrane: unraveling the pathophysiology and treatment of chronic subdural hematoma. Front Surg. 2025; 12:1694048. PMID: 41446328.

    Read at: PubMed

  • Published 11/29/2024

    Sconzo D, Enriquez-Marulanda A, Simwatachela E, Vu T, Setty B, Osamu S, El-Araby A, Holsapple J. Retreatment predictors after percutaneous balloon gangliolysis for trigeminal neuralgia. Neurosurg Rev. 2024 Nov 29; 47(1):877. PMID: 39609293.

    Read at: PubMed

  • Published 6/14/2024

    Jaishankar R, Teichmann D, Hayward A, Holsapple JW, Heldt T. Open cranium model for the study of cerebrovascular dynamics in intracranial hypertension. J Neurosci Methods. 2024 Sep; 409:110196. PMID: 38880344.

    Read at: PubMed

  • Published 3/4/2024

    Urbach H, Sileo N, Lerma S, Nguyen K, Sosa Soto G, Nielsen M, Heiderich A, Holsapple J, Vuppula S, Campbell JI. Ceftaroline for Central Nervous System Infections: Case Report of a Young Infant, and Scoping Review. Pediatr Infect Dis J. 2024 Jul 01; 43(7):663-668. PMID: 38451889.

    Read at: PubMed

View All 33 Publications:   View Full Profile in BUMC

Other Positions

  • Associate Professor, Neurosurgery
    Boston University Chobanian & Avedisian School of Medicine

Websites

Education

  • University of Kansas, MD
  • Drake University, BA

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