Gustavo Mostoslavsky, MD, PhD

Associate Professor, Microbiology

Gustavo Mostoslavsky
617.358.1018
670 Albany St Biosquare III

Biography

Expertise includes: Stem cells; Induced Pluripotent Stem cells (iPSC); Gene transfer and Gene editing; Lentiviruses; Disease modeling; Intestinal organoids; Neural differentiation; Immune relevant cell differentiation.

Other Positions

  • Associate Professor, Gastroenterology, Medicine, Boston University School of Medicine
  • Boston Medical Center
  • Member, Pulmonary Center, Boston University
  • Co-Director, Center for Regenerative Medicine, Boston University
  • Member, Evans Center for Interdisciplinary Biomedical Research, Boston University
  • Graduate Faculty (Primary Mentor of Grad Students), Boston University School of Medicine, Graduate Medical Sciences
  • Member, Genome Science Institute, Boston University

Education

  • Universidad Nacional de Tucumán, MD
  • The Hebrew University of Jerusalem, PhD

Publications

  • Published on 5/6/2020

    Kanchan K, Iyer K, Yanek LR, Carcamo-Orive I, Taub MA, Malley C, Baldwin K, Becker LC, Broeckel U, Cheng L, Cowan C, D'Antonio M, Frazer KA, Quertermous T, Mostoslavsky G, Murphy G, Rabinovitch M, Rader DJ, Steinberg MH, Topol E, Yang W, Knowles JW, Jaquish CE, Ruczinski I, Mathias RA. Genomic integrity of human induced pluripotent stem cells across nine studies in the NHLBI NextGen program. Stem Cell Res. 2020 May 06; 46:101803. PMID: 32442913.

    Read at: PubMed
  • Published on 1/30/2020

    Hurley K, Ding J, Villacorta-Martin C, Herriges MJ, Jacob A, Vedaie M, Alysandratos KD, Sun YL, Lin C, Werder RB, Huang J, Wilson AA, Mithal A, Mostoslavsky G, Oglesby I, Caballero IS, Guttentag SH, Ahangari F, Kaminski N, Rodriguez-Fraticelli A, Camargo F, Bar-Joseph Z, Kotton DN. Reconstructed Single-Cell Fate Trajectories Define Lineage Plasticity Windows during Differentiation of Human PSC-Derived Distal Lung Progenitors. Cell Stem Cell. 2020 Apr 02; 26(4):593-608.e8. PMID: 32004478.

    Read at: PubMed
  • Published on 1/10/2020

    Mithal A, Capilla A, Heinze D, Berical A, Villacorta-Martin C, Vedaie M, Jacob A, Abo K, Szymaniak A, Peasley M, Stuffer A, Mahoney J, Kotton DN, Hawkins F, Mostoslavsky G. Generation of mesenchyme free intestinal organoids from human induced pluripotent stem cells. Nat Commun. 2020 01 10; 11(1):215. PMID: 31924806.

    Read at: PubMed
  • Published on 10/1/2019

    Engler AE, Mostoslavsky G, Miller L, Rock JR. Isolation, Maintenance and Differentiation of Primary Tracheal Basal Cells from Adult Rhesus Macaque. Methods Protoc. 2019 Oct 01; 2(4). PMID: 31581513.

    Read at: PubMed
  • Published on 5/16/2019

    Dhyani M, Joshi N, Bemelman WA, Gee MS, Yajnik V, D'Hoore A, Traverso G, Donowitz M, Mostoslavsky G, Lu TK, Lineberry N, Niessen HG, Peer D, Braun J, Delaney CP, Dubinsky MC, Guillory AN, Pereira M, Shtraizent N, Honig G, Polk DB, Hurtado-Lorenzo A, Karp JM, Michelassi F. Challenges in IBD Research: Novel Technologies. Inflamm Bowel Dis. 2019 05 16; 25(Suppl 2):S24-S30. PMID: 31095703.

    Read at: PubMed
  • Published on 7/19/2018

    Sommer CA, Capilla A, Molina-Estevez FJ, Gianotti-Sommer A, Skvir N, Caballero I, Chowdhury S, Mostoslavsky G. Modeling APC mutagenesis and familial adenomatous polyposis using human iPS cells. PLoS One. 2018; 13(7):e0200657. PMID: 30024920.

    Read at: PubMed
  • Published on 5/4/2018

    Park S, Mostoslavsky G. Generation of Human Induced Pluripotent Stem Cells Using a Defined, Feeder-Free Reprogramming System. Curr Protoc Stem Cell Biol. 2018 05; 45(1):e48. PMID: 30040234.

    Read at: PubMed
  • Published on 3/1/2018

    Ferrer CM, Alders M, Postma AV, Park S, Klein MA, Cetinbas M, Pajkrt E, Glas A, van Koningsbruggen S, Christoffels VM, Mannens MMAM, Knegt L, Etchegaray JP, Sadreyev RI, Denu JM, Mostoslavsky G, van Maarle MC, Mostoslavsky R. An inactivating mutation in the histone deacetylase SIRT6 causes human perinatal lethality. Genes Dev. 2018 03 01; 32(5-6):373-388. PMID: 29555651.

    Read at: PubMed
  • Published on 10/10/2017

    Kitano K, Schwartz DM, Zhou H, Gilpin SE, Wojtkiewicz GR, Ren X, Sommer CA, Capilla AV, Mathisen DJ, Goldstein AM, Mostoslavsky G, Ott HC. Bioengineering of functional human induced pluripotent stem cell-derived intestinal grafts. Nat Commun. 2017 10 10; 8(1):765. PMID: 29018244.

    Read at: PubMed
  • Published on 10/1/2017

    Jamalpour M, Li X, Cavelier L, Gustafsson K, Mostoslavsky G, Höglund M, Welsh M. Tumor SHB gene expression affects disease characteristics in human acute myeloid leukemia. Tumour Biol. 2017 Oct; 39(10):1010428317720643. PMID: 28982308.

    Read at: PubMed

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