Dr.Koo’s research interests span the areas of neuroimaging, particularly the development of multi-modal magnetic resonance imaging (MRI) and analysis methods. Neuroimaging commonly aims to identify difference between healthy and unhealthy brains in a quantitative way. However, due to the complexity of the human brain, it is extremely difficult to analyze early stage or slow disease progressions from visually inspecting the image. Dr.Koo’s work focuses on developing novel imaging protocols and mapping methods with better sensitivities on monitoring neurological and functional changes in the brain. Dr.Koo also serves as an imaging core director at National Emerging Infectious Disease Laboratories (NEIDL). The goal is to develop multimodal imaging protocol that allows in-vivo monitoring on different stages of tissue inflammatory/immune responses.
- Faculty, National Emerging Infectious Disease Lab, Boston University
- Graduate Faculty (Primary Mentor of Grad Students), Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences
- Hanyang University, PhD
- Hanyang University, MS
- Hanyang University, BS
- Published on 3/30/2022
Guan Y, Ebrahimzadeh SA, Cheng CH, Chen W, Leung T, Bigornia S, Palacios N, Garelnabi MO, Scott T, Bhadelia R, Tucker KL, Koo BB. Association of Diabetes and Hypertension With Brain Structural Integrity and Cognition in the Boston Puerto Rican Health Study Cohort. Neurology. 2022 Apr 12; 98(15):e1534-e1544. PMID: 35354581.
- Published on 3/15/2022
Gonuguntla V, Yang E, Guan Y, Koo BB, Kim JH. Brain signatures based on structural MRI: Classification for MCI, PMCI, and AD. Hum Brain Mapp. 2022 Jun 15; 43(9):2845-2860. PMID: 35289025.
- Published on 1/3/2022
Yang E, Kim CK, Guan Y, Koo BB, Kim JH. 3D multi-scale residual fully convolutional neural network for segmentation of extremely large-sized kidney tumor. Comput Methods Programs Biomed. 2022 Mar; 215:106616. PMID: 35026623.
- Published on 10/6/2021
Cheng CH, Alshelh Z, Guan Y, Sullivan K, Loggia ML, Koo BB. Association of the tissue microstructural diffusivity and translocator protein PET in Gulf War Illness. Brain Behav Immun Health. 2021 Dec; 18:100364. PMID: 34693367.
- Published on 8/26/2021
Keating D, Zundel CG, Abreu M, Krengel M, Aenlle K, Nichols MD, Toomey R, Chao LL, Golier J, Abdullah L, Quinn E, Heeren T, Groh JR, Koo BB, Killiany R, Loggia ML, Younger J, Baraniuk J, Janulewicz P, Ajama J, Quay M, Baas PW, Qiang L, Conboy L, Kokkotou E, O'Callaghan JP, Steele L, Klimas N, Sullivan K. Boston biorepository, recruitment and integrative network (BBRAIN): A resource for the Gulf War Illness scientific community. Life Sci. 2021 Nov 01; 284:119903. PMID: 34453948.
- Published on 8/26/2021
Steele L, Klimas N, Krengel M, Quinn E, Toomey R, Little D, Abreu M, Aenlle K, Killiany R, Koo BB, Janulewicz P, Heeren T, Clark AN, Ajama J, Cirillo J, Buentello G, Lerma V, Coller JK, Sullivan K. Brain-Immune Interactions as the Basis of Gulf War Illness: Clinical Assessment and Deployment Profile of 1990-1991 Gulf War Veterans in the Gulf War Illness Consortium (GWIC) Multisite Case-Control Study. Brain Sci. 2021 Aug 26; 11(9). PMID: 34573153.
- Published on 7/1/2021
Farris CW, Killiany RJ, O'Donoghue E, Koo BB, Wainford RD, Moss MB, Rosene DL, Moore TL. The relationship of age and hypertension with cognition and gray matter cerebral blood volume in a rhesus monkey model of human aging. Behav Neurosci. 2021 Oct; 135(5):680-692. PMID: 34197136.
- Published on 2/1/2021
Bhattacharya B, Xiao S, Chatterjee S, Urbanowski M, Ordonez A, Ihms EA, Agrahari G, Lun S, Berland R, Pichugin A, Gao Y, Connor J, Ivanov AR, Yan BS, Kobzik L, Koo BB, Jain S, Bishai W, Kramnik I. The integrated stress response mediates necrosis in murine Mycobacterium tuberculosis granulomas. J Clin Invest. 2021 02 01; 131(3). PMID: 33301427.
- Published on 11/20/2020
Guan Y, Cheng CH, Chen W, Zhang Y, Koo S, Krengel M, Janulewicz P, Toomey R, Yang E, Bhadelia R, Steele L, Kim JH, Sullivan K, Koo BB. Neuroimaging Markers for Studying Gulf-War Illness: Single-Subject Level Analytical Method Based on Machine Learning. Brain Sci. 2020 Nov 20; 10(11). PMID: 33233672.
- Published on 7/31/2020
Cheng CH, Koo BB, Calderazzo S, Quinn E, Aenlle K, Steele L, Klimas N, Krengel M, Janulewicz P, Toomey R, Michalovicz LT, Kelly KA, Heeren T, Little D, O'Callaghan JP, Sullivan K. Alterations in high-order diffusion imaging in veterans with Gulf War Illness is associated with chemical weapons exposure and mild traumatic brain injury. Brain Behav Immun. 2020 10; 89:281-290. PMID: 32745586.
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