Ann C. McKee, MD

Professor, Neurology

781.687.2913
150 S Huntington Avenue

Biography

Dr. McKee completed her undergraduate studies at the University of Wisconsin and received her medical degree from the Case Western Reserve School of Medicine. She completed residency training in neurology at Cleveland Metropolitan General Hospital and fellowship training in neuropathology at Massachusetts General Hospital. She was Assistant Professor of Neuropathology at Harvard Medical School from 1991-94, when she became Associate Professor of Neurology and Pathology at Boston University School of Medicine. In 2011, she was promoted to Professor of Neurology and Pathology. Dr. McKee directs the Neuropathology Service for the New England Veterans Administration Medical Centers (VISN-1) and the Brain Banks for the Boston University Alzheimer’s Disease Center, Center for the Study of Traumatic Encephalopathy, Framingham Heart Study, and Centenarian Study, which are all based at the Bedford VAMC. Dr. McKee is also the Chief Neuropathologist for the National VA ALS Brain Bank.

Dr. McKee’s research interests center on the neuropathological alterations of neurodegenerative diseases, with a primary focus on the role of tau protein, axonal injury, trauma, vascular injury, and neurodegeneration. Much of her current work centers on mild traumatic brain injury from contact sports and military service and its long-term consequences. As a board-certified neurologist and neuropathologist, she is particularly interested in the clinical, behavioral and psychological manifestations of pathological disease and the neuroanatomical localization of clinical symptoms. She has written widely on many neurodegenerative diseases including Alzheimer’s disease, Lewy Body disease, Parkinson’s Disease, Progressive Supranuclear Palsy, Multiple System Atrophy, Frontotemporal Degeneration, Corticobasal Degeneration and Chronic Traumatic Encephalopathy (CTE). She has been an invited participant in several NIH-sponsored workshops on Progressive Supranuclear Palsy, Vascular Dementia and Traumatic Brain Injury. Dr. McKee’s work has been essential in establishing the clinical and pathological spectrum of trauma induced neurodegenerative disease, including CTE and Chronic Traumatic Encephalomyelopathy.

Recently, she has received widespread acclaim for her case series featured in the Journal of the American Medical Association (JAMA) that found nearly every former National Football League (NFL) player who played at least one regular season game and whose brain then was donated for research was diagnosed post-mortem with Chronic Traumatic Encephalopathy (CTE).

Other Positions

  • Professor, Pathology & Laboratory Medicine, Boston University School of Medicine
  • Mentor for Graduate Medical Students, Boston University School of Medicine, Graduate Medical Sciences
  • VA Boston Healthcare System

Education

  • Case School of Medicine, MD
  • University of Wisconsin-Madison, BS

Publications

  • Published on 1/3/2019

    Robinson ME, McKee AC, Salat DH, Rasmusson AM, Radigan LJ, Catana C, Milberg WP, McGlinchey RE. Positron emission tomography of tau in Iraq and Afghanistan Veterans with blast neurotrauma. Neuroimage Clin. 2019; 21:101651. PMID: 30642757.

    Read at: PubMed
  • Published on 12/20/2018

    McKee AC, Alosco ML. Assessing Subconcussive Head Impacts in Athletes Playing Contact Sports-The Eyes Have It. JAMA Ophthalmol. 2018 Dec 20. PMID: 30570658.

    Read at: PubMed
  • Published on 12/18/2018

    Armstrong RA, McKee AC, Stein TD, Alvarez VE, Cairns NJ. Cortical degeneration in chronic traumatic encephalopathy and Alzheimer's disease neuropathologic change. Neurol Sci. 2018 Dec 18. PMID: 30564964.

    Read at: PubMed
  • Published on 12/1/2018

    Walt GS, Burris HM, Brady CB, Spencer KR, Alvarez VE, Huber BR, Guilderson L, Abdul Rauf N, Collins D, Singh T, Mathias R, Averill JG, Walker SE, Robey I, McKee AC, Kowall NW, Stein TD. Chronic Traumatic Encephalopathy Within an Amyotrophic Lateral Sclerosis Brain Bank Cohort. J Neuropathol Exp Neurol. 2018 Dec 01; 77(12):1091-1100. PMID: 30299493.

    Read at: PubMed
  • Published on 11/4/2018

    Cherry JD, Mez J, Crary JF, Tripodis Y, Alvarez VE, Mahar I, Huber BR, Alosco ML, Nicks R, Abdolmohammadi B, Kiernan PT, Evers L, Svirsky S, Babcock K, Gardner HM, Meng G, Nowinski CJ, Martin BM, Dwyer B, Kowall NW, Cantu RC, Goldstein LE, Katz DI, Stern RA, Farrer LA, McKee AC, Stein TD. Variation in TMEM106B in chronic traumatic encephalopathy. Acta Neuropathol Commun. 2018 11 04; 6(1):115. PMID: 30390709.

    Read at: PubMed
  • Published on 10/23/2018

    Morrison FG, Miller MW, Wolf EJ, Logue MW, Maniates H, Kwasnik D, Cherry JD, Svirsky S, Restaino A, Hildebrandt A, Aytan N, Stein TD, Alvarez VE, McKee AC, Huber BR. Reduced interleukin 1A gene expression in the dorsolateral prefrontal cortex of individuals with PTSD and depression. Neurosci Lett. 2019 Jan 23; 692:204-209. PMID: 30366016.

    Read at: PubMed
  • Published on 9/7/2018

    Hsu ET, Gangolli M, Su S, Holleran L, Stein TD, Alvarez VE, McKee AC, Schmidt RE, Brody DL. Astrocytic degeneration in chronic traumatic encephalopathy. Acta Neuropathol. 2018 Dec; 136(6):955-972. PMID: 30194648.

    Read at: PubMed
  • Published on 9/1/2018

    Adams JW, Alvarez VE, Mez J, Huber BR, Tripodis Y, Xia W, Meng G, Kubilus CA, Cormier K, Kiernan PT, Daneshvar DH, Chua AS, Svirsky S, Nicks R, Abdolmohammadi B, Evers L, Solomon TM, Cherry JD, Aytan N, Mahar I, Devine S, Auerbach S, Alosco ML, Nowinski CJ, Kowall NW, Goldstein LE, Dwyer B, Katz DI, Cantu RC, Stern RA, Au R, McKee AC, Stein TD. Lewy Body Pathology and Chronic Traumatic Encephalopathy Associated With Contact Sports. J Neuropathol Exp Neurol. 2018 Sep 01; 77(9):757-768. PMID: 30053297.

    Read at: PubMed
  • Published on 7/23/2018

    Alosco ML, Tripodis Y, Fritts NG, Heslegrave A, Baugh CM, Conneely S, Mariani M, Martin BM, Frank S, Mez J, Stein TD, Cantu RC, McKee AC, Shaw LM, Trojanowski JQ, Blennow K, Zetterberg H, Stern RA. Cerebrospinal fluid tau, Aß, and sTREM2 in Former National Football League Players: Modeling the relationship between repetitive head impacts, microglial activation, and neurodegeneration. Alzheimers Dement. 2018 Sep; 14(9):1159-1170. PMID: 30049650.

    Read at: PubMed
  • Published on 5/1/2018

    Alosco ML, Mez J, Tripodis Y, Kiernan PT, Abdolmohammadi B, Murphy L, Kowall NW, Stein TD, Huber BR, Goldstein LE, Cantu RC, Katz DI, Chaisson CE, Martin B, Solomon TM, McClean MD, Daneshvar DH, Nowinski CJ, Stern RA, McKee AC. Age of first exposure to tackle football and chronic traumatic encephalopathy. Ann Neurol. 2018 May; 83(5):886-901. PMID: 29710395.

    Read at: PubMed

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