WCVI News & Announcements
Dr. Francesca Seta Invited Editorial in AHA Circulation Research Journal
The WCVI is proud to share that Dr. Francesca Seta has published an Invited Editorial on Circulation Research titled "Endothelium: A Barrier Against Aortic Dissection." Find her article here: https://doi.org/10.1161/CIRCRESAHA.125.326722
Dr. Francesca Seta Awarded NIH and AHA Research Grants
Congratulations to Dr. Francesca Seta on earning two grants! One is an NIH R21 grant HL173511 for her research on iPSC-derived VSMC for high-throughput screening of small molecules for aortic aneurysm. The other is an AHA grant 25PBA1507865 for her research on the development of small molecule sirt1 activators for aortic... More
Dr. Francesca Seta and Dr. Jingyan Han Awarded NHLBI Grant
The WCVI is pleased to announce that Dr. Francesca Seta, PhD., and Dr. Jingyan Han, PhD., have been awarded a an R01 grant from the National Heart, Lung, and Blood Institute (NHLBI). This grant will be used to study the role of oxidative stress-induced modifications on the enzyme sirtuin-1 in... More
Dr. Francesca Seta Recent Article Publication in Vascular Pharmacology
Congratulations to Dr. Francesca Seta, PhD., on her recent publication in Vascular Pharmacology! The article is titled "Pharmacological activation of NO-sensitive guanylyl cyclase ameliorates obesity-induced arterial stiffness" and can be viewed here: Pharmacological activation of NO-sensitive guanylyl cyclase ameliorates obesity-induced arterial stiffness
Dr. Jessica Fetterman Receives DEIA Pilot Grant
Dr. Jessica Fetterman of WCVI's Vascular Biology group is a deserving recipient of the first annual DEIA Pilot Grant. The Department of Medicine launched its inaugural Diversity, Equity, Inclusion, and Accessibility (DEIA) Pilot Grant program this year, supporting innovative projects led by interdisciplinary teams of faculty, trainees, and staff. Proposals focused on... More
Dr. Noyan Gokce Awarded NIH Research Grant
Congratulations to Dr. Noyan Gokce and co-PI J. Schlezinger for earning this grant, which was awarded for their proposal to investigate environmental pollutants detrimental to the cardiovascular system. Read on for Dr. Gokce's summary of the project: Environmental pollutants that have contaminated our food supplies and consumer products, some termed “forever chemicals”, More
Congratulations to Dr. Jessica Fetterman on Winning the Smith Family Foundation’s Odyssey Award!
WCVI member Dr. Jessica Fetterman, PhD, FAHA, Assistant Professor of Medicine, has been selected for the Smith Family Foundation's Odyssey Award! Created in 2017 to fuel creativity and innovation in junior investigators in the basic sciences, the Odyssey Award supports the pursuit of high impact ideas to generate breakthroughs and... More
NIH Grant Awarded: Targeting Energetics to Improve Outcomes in Hypertrophic Cardiomyopathy
We are pleased to announce an NIH grant has been awarded to support Dr. Ivan Luptak's research on hypertrophic cardiomyopathy (HCM). This project aims to explore interventions to improve mitochondrial function and energy balance in HCM, potentially delaying or reversing the progression of this condition to heart failure. Using innovative... More
Cardiovascular Medicine 2022 DoM Evans Days Award Winners!
Congratulations to Whitaker Cardiovascular Institute DoM Evans Day award winners!! Outstanding Citizenship Award- Frederick Ruberg, MD Junior Faculty Mentoring Award- Deepa Gopal, MD, MS Clinical Oral Presentation Winner- Ross Okazaki
Dr. Jiang and his group reported recently that neutrophil elastase (NE) regulates vascular endothelial cell permeability.
Dr. Jiang and his group reported recently that neutrophil elastase (NE), a protease secreted from neutrophils, regulates vascular endothelial cell permeability. NE cleaves and activates protease-activated receptor-2, leading to actomyosin cytoskeletal activation, cell junction molecule VE-cadherin degradation, and increased endothelial permeability. Inhibition and deletion of NE in mice protect obesogenic... More