Introduction to the Mouse Assisted Reproductive Technology Core

CRISPR/Cas9-mediated knockout of the Tyrosinase (albino) gene in C57BL/6J mice

Boston University Mouse Assisted Reproductive Technology (MART) Core is part of the BU Animal Science Center (ASC) with a mandate not only to oversee the breeding of complex genetically modified mice but also to preserve rare and valuable strains for later use.  MART Core maintains a large repository of frozen sperm and embryo collections for the research community that can be revived anytime to generate live mice.  MART Core staff are experienced in collecting mouse sperm, harvesting unfertilized eggs, conducting in-vitro fertilization and embryo transplantation.  In addition, to eliminate common mouse pathogens in the offspring born to mice of uncertain health status (example, mice coming from other facilities and countries), we perform cesarean section, embryo transfer, and in-vitro fertilization.  All of the above procedures are conducted in our ABSL-2 laboratories to preserve the specific pathogen-free health status of our mouse colonies and breeding program.

 

 

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