Dr. Jiang and his group reported recently that neutrophil elastase (NE) regulates vascular endothelial cell permeability.
Dr. Jiang and his group reported recently that neutrophil elastase (NE), a protease secreted from neutrophils, regulates vascular endothelial cell permeability. NE cleaves and activates protease-activated receptor-2, leading to actomyosin cytoskeletal activation, cell junction molecule VE-cadherin degradation, and increased endothelial permeability. Inhibition and deletion of NE in mice protect obesogenic diet-induced vascular leakage and immune […]
Postdoctoral Associate Position: The Boston University School of Medicine seeks recent Ph.D. graduates with a metabolic or immunologic research background to join the Pharmacology and Whitaker Cardiovascular Institute as Post-doctoral Research Associates. The interests of the research group are focused on understanding the metabolic regulation of hematopoiesis, systemic inflammation related to obesity, fatty liver diseases, vascular […]
Recent achievements in the WCVI. Zhen Jiang MD, PhD and Jiang Lab. Spotlight article in Molecular and Cellular Biology (MCB) with editor’s comment. (Editor’s comments)(Full article) Mol. Cell. Biol.-2018-04-CDP138 (PDF version)