Host-Pathogen Interactions
Virus/Host interaction; viral domination of protein synthesis; antiviral compounds, systems biology of viral hemorrhagic fever, novel approaches to virus detection
Host factor-based therapy development and infection mechanism for filoviruses and other high containment viruses
Filovirus pathogenesis, animal model development, viral persistence and latency, advanced development of vaccines and therapeutics for high consequence pathogens
Enveloped Virus Entry Mechanisms; Innate Immune Evasion Mechanisms; Inflammation & HIV; Nanotherapeutics
Hemorrhagic fever viral pathogenesis, animal model development, utilization of implantable telemetry for real-time physiologic data, advanced development of medical countermeasures
Reproductive immunology and the pathogenesis of gonococcal and chlamydia infections
Genes controling host resistance and susceptibility to tuberculosis; biology of tuberculosis granulomas; mechanisms of macrophage activation and differentiation
Acute lower respiratory tract infection; cytokines; innate immunity; neutrophil recruitment and activation; pneumonia; transcriptional and post-transcriptional regulation of gene expression
Host response to filovirus infection; molecular mechanisms of filovirus replication and transcription
HIV transmission pathogenesis and role of antibodies in protecting against infection
Molecular biology of HIV-1; the role of virus-host cell interactions in pathogenesis
Vaccine development; microbial immunity and pathogenesis; effect of bacterial products on eukaryotic cells