Ronald H. Goldstein, M.D.
Faculty and Fellows
Professor of Medicine
Medical School: SUNY, Downstate
Internship: Boston City Hospital
Residency: Boston City Hospital
Fellowship: Boston University School of Medicine
- Pulmonary Matrix Biology related to Pulmonary Fibrosis and Emphysema
- Pulmonary Fibrosis
Our laboratory is exploring the regulation of the alveolar matrix during the development of early emphysema and fibrosis. The loss of matrix substances results in emphysema whereas the excessive deposition of matrix substances results in pulmonary fibrosis. Employing the techniques of cellular and molecular biology, we are developing methods to modulating the levels of collagen, elastin and other key matrix substances in the alveolar wall. These approaches are studied in wild type and transgenic murine models of emphysema and fibrosis.
We have extensive experience in the diagnosis and management of individuals with pulmonary fibrosis. In human studies, our clinical experimental interest involves the use of novel substances to treat idiopathic pulmonary fibrosis (IPF). We participate in several clinical studies to evaluate the efficacy of these agents in the pathogenesis of IPF.
Please see BU Profile for complete Publications list
- Regulation of elastin gene transcription by proteasome dysfunction
- Engraftment of Neonatal Lung Fibroblasts into the Normal and Elastase-Injured Lung
- NF-kB induced by IL-1B inhibits elastin transcription and myofibroblast phenotype
- Boston University Translational-Clinical Research>Interstitial Lung Diseases and Pulmonary Fibrosis
- Boston University Clinical Centers> Interstitial Lung Disease
Dr. Goldstein sees patients at
- Boston Medical Center, Doctor’s Office Building 4th floor
- Boston VA Healthcare System