Arjun Guha, PhD

Assistant Professor
PhD Program: National Center for Biological Sciences, TIFR, India
Post-doctoral Fellowships/Training:  University of California, San Francisco;  Boston University Medical School, Boston


Research Interests:

  • Cell fate specification and cellular plasticity in lung development and repair
  • Non-classical stem cell hierarchies
  • Pulmonary neuroepithelial cells and their microenvironment
  • Notch signaling

Selected Publications:

  1. Guha, A; Sriram V; Krishnan KS; Mayor, S. Shibire mutations reveal distinct dynamin independent and -dependent endocytic pathways in primary cultures of Drosophila hemocytes. J Cell Sci. 2003 Aug 15; 116 (Pt 16):3373-86.
  2. Guha A; Kornberg, TB. Tracheal branch repopulation precedes induction of the Drosophila dorsal air sac primordium. Dev Biol. 2005 Nov 1; 287(1): 192-200.
  3. Kornberg TB; Guha, A. Understanding morphogen gradients: a problem of dispersion and containment. Curr Opin Genet Dev. 2007 Aug; 17(4): 264-71.
  4. Guha, A; Lin, L; Kornberg, TB. Organ renewal in Drosophila by differentiated cells that restart a mitotic program. Proc. Natl. Acad. Sci., USA 2008 Aug 5; 105(31): 10832-6.
  5. Guha, A; Lin, L; Kornberg, TB. Regulation of Drosophila matrix metalloprotease Mmp2 is essential for wing imaginal disc:trachea association and air sac tubulogenesis. Dev Biol. 2009 Nov 15;335(2):317-26
  6. Guha, A;Vasconcelos, M; Cai, Y;Yoneda, M;Hinds, A;Qian, J; Li G;Johnson, J;Kimura, S; Guo, J;McMahon, J; McMahon, A; Cardoso, W  Neuroepithelial body microenvironment is a niche for a distinct subset of Clara-like precursors in the developing airways. Proc Natl Acad Sci USA 2012 109(31):12592-12597
  7. Guha A; Vasconcelos, M; Zhao, R; Gower, A;  Rajagopal, J; Cardoso, W. Analysis of Notch signaling-dependent gene expression in developing airways reveals diversity of Clara cells. PLoS One 2014 9(2):e88848.
  8. Rao PR, Lin L, Huang, H., Guha A, Roy, SR Kornberg TB. Developmental compartments in the larval trachea of Drosophila. eLife  2015;10.7554
  9. Yan Cai, Tomita T, Kurotani R, Kido T, Yoneda M, Mitzner W, Guha A, Shioko Kimura. Transgenically expressed secretoglobin 3A2 accelerates resolution of bleomycin-induced pulmonary fibrosis in mice. BMC Pulmonary Medicine 2015,15:72
  10. Guha A, Deshpande A, Jain A, Li G, Sebastiani P, Cardoso WV. Airway Neuroepithelial Bodies harbor distinctive multipotent Club cells that contributetoward airway maintenance and post-injury repair. Manuscript submitted. 
  11. Guha A and Bhavsar R. Role of Notch signaling in the lung homeostasis and disease. Invited review. Manuscript submitted.