Research news
Student Spotlight: Gabrielle Ruban, M2
Gabrielle Ruban is a current M2 student, 2025 MSSRP/LEADS researcher, and CARE student. Under the mentorship of Dr. Karsten Lunze, she has been working on two projects that are based in Eastern Europe. Her main individual project is within the SCRIPT (Stigma Coping to Reduce HIV Risks and Improve Substance Use Prevention and Treatment) study, which is based in Russia, while the other project Gabrielle has contributed to is the Ukraine-based SUPRA (Substance Use Prevention for Recently Displaced Adults) study.
Based on data from a trial conducted in Russia, the SCRIPT (Stigma Coping to Reduce HIV Risks and Improve substance use Prevention and Treatment) study’s initial goal was to assess Acceptance and Commitment approaches as a possible intervention for people living with HIV who inject drugs, with the goal of addressing the consequences of internalized intersectional stigma related to HIV status and substance use. The aim of her main project within the SCRIPT study is to investigate whether intersectional stigma moderates the hypothesized association between exposure to intimate partner violence (IPV) and poorer health-related quality of life (HRQoL) outcomes among HIV-positive people who inject drugs in Russia. Critically, the associations between IPV and HRQoL as well as intersectional stigma have not been well explored in this population. This knowledge gap especially applies to Russia, where injection drug use, HIV incidence, and IPV exposure remain exceptionally high and often co-occur. No published studies have examined whether intersectional stigma moderates the link between intimate partner violence exposure and worse health-related quality of life outcomes in people with HIV who use drugs. In this relationship, stigma may intensify the consequences of IPV, such as by promoting shame, low self-worth, worsening mental health symptoms, and disengagement or avoidance of healthcare. Stigma might also be associated with declines across various domains of HRQoL.
The SUPRA survey, in contrast, was conducted in Ukraine and involved qualitative exploration of substance use patterns among individuals internally displaced by Russia’s war in Ukraine, with the ultimate goal of developing an intervention based on Acceptance and Commitment approaches to reduce substance use among individuals affected by this humanitarian crisis. Gabrielle's involvement in the SUPRA study has expanded her qualitative research skillset, which was a goal she explicitly outlined as wanting to achieve during her time in medical school, given that she exclusively has had quantitative research experiences up until this point. Since joining the SUPRA team last fall, Gabrielle has used her Russian and Ukrainian language skills to help translate the interview notes to English, as well as contributed to the development and execution of the rapid qualitative analysis plan. This process enables us to systematically analyze the free listing interviews to capture key substances used during the active war in Ukraine, along with their alternative names, forms, modes of use, the populations most likely to use them, and their consequences at both individual and societal levels.
For the SCRIPT-based study, Gabrielle's primary mentor has been Dr. Karsten Lunze, who is also the principal investigator of the study. During the development of the research question and analytic plan, and also received guidance from several experts, including Emily Sisson (Senior Director of Research Operations) and Dr. Jin Wei (Biostatistics) for statistical input as well as Dr. Jeffrey Samet (General Internal Medicine) for his expertise in substance use treatment among international populations with HIV, including those in Russia and Ukraine. For the SUPRA study, Gabrielle's been mentored primarily by Dr. Lunze, as well as Dr. Claire Green, Assistant Professor of Population and Family Health at Columbia University Mailman School of Public Health.
As the daughter of two Ukrainian immigrants, Gabrielle has been deeply shaped by her Eastern European heritage, culturally and linguistically. In addition to her heritage, her experiences in crisis counseling, harm reduction outreach, and addiction medicine education during the pandemic and prior to medical school sparked her interest in understanding how trauma and social determinants impact care engagement as well as confirmed her decision to pursue a career in medicine. She became particularly interested in how socioenvironmental exposures such as intimate partner violence, intersectional stigma, and substance use intersect and affect health outcomes, including healthcare engagement, infectious disease risk, and overall quality of life. Her research is both important and timely because it addresses overlapping and understudied drivers of poor health outcomes among highly vulnerable populations in active and evolving contexts.
Gabrielle and the research team are currently in the data analysis phase for the SCRIPT-based study on intersectional stigma, intimate partner violence, and health-related quality of life. She has presented two posters from the SUPRA project since joining the team. She presented gender-specific findings on substance use patterns among internally displaced individuals in Ukraine at the Chobanian and Avedisian School of Medicine Medical Student Research Symposium in February 2026. She also presented a poster focused on substance use among internally displaced women at the Seventeenth Massachusetts Medical Society Research Poster Symposium on March 21, 2026.
Student Spotlight: Milan Dolezal, M2
Milan Dolezal is a current M2 student, 2025 MSSRP/LEADS researcher, and CARE student under the mentorship of Dr. Karsten Lunze. Her research, "Peer perspectives on the use of embodied conversational agents to improve buprenorphine retention: a community-engaged qualitative study," explores whether an embodied conversational agent can help improve buprenorphine treatment retention for people with opioid use disorder (OUD). Through focus groups with people in recovery, they identified the kinds of support that would be most useful and used those insights to shape the intervention’s design. Milan and her mentor are now using the agent in a clinical trial where we examine whether this patient-informed digital tool can help people stay engaged in treatment.
Milan was drawn to substance use research because of the prevalence of substance use disorder in our BMC community. She has had the opportunity to learn from the clinicians and researchers at BMC who are providing exceptional care and leading important research in this area. Her project has allowed her to work alongside and learn from people with OUD in crafting interventions grounded in lived experiences. Despite the efficacy of buprenorphine treatment in reducing all-cause mortality for people with OUD, discontinuation rates are high. This research is important because it aims to improve retention rates with a digital tool that has been successful in improving retention in other patient populations but has never been tested within the OUD community.
Through her research experience, Milan has learned that she is motivated when working with people with OUD and can see herself treating OUD as a physician in the future. She is in the process of submitting a manuscript now and presented a research poster at the Medical Student Research Symposium in February.
Mentor Spotlight: David Greer, MD
David Greer, MD, Chair and Chief of NeurologyDr. David Greer is Professor and Chair of the Department of Neurology at Boston University School of Medicine and the Richard B. Slifka Chief of Neurology at Boston Medical Center. He has been a neurointensivist since 2001, having trained at Massachusetts General Hospital, where he began his career. He was then Vice Chair at Yale from 2010-17, before joining Boston University and Boston Medical Center in 2017. Dr. Greer did not originally envision a career in research, but growing frustration with numerous unanswered and neglected questions motivated him to take action by asking, "why not me?". He began modestly by creating a database and compiling records of patients in coma, which over the years expanded into a long-term commitment and ultimately became his life's work.
Student Spotlight: Sophia Bahad, M2
Sophia Bahad is a current M2 student and 2025 MSSRP researcher. This past summer she presented her poster at the Boston Medical Center Pediatric Research Day titled, “Comparing Area-Based Sociodemographic Measures and Their Association with Latent TB Infection at Boston Medical Center.” Mentored by Dr. Jeffrey Campbell in the Pediatric Infectious Disease Department at BMC, Sophia’s research rethinks how the “household” is defined in latent tuberculosis infection (LTBI) prevention and care. LTBI often clusters within households, yet households are typically treated as static, co-residential units in clinical care. Using a mixed-methods approach, Sophia's project characterizes household composition and fluidity among patients with LTBI in Boston and examines how household structure relates to disclosure patterns and TB-relevant risk factors. Based on patient interviews, she created participant-centered household diagrams to develop household membership phenotypes that may inform more effective household-level LTBI care strategies. Sophia also notes the project's research assistants, Ariane Garing and Dorine Lavache, who were instrumental to study execution and data collection.
Sophia studied medical anthropology as an undergraduate at Boston University, where she became deeply interested in how social context shapes health behaviors and outcomes. Medical anthropology helped Sophia understand why systems function the way they do; she carried this outlook into her medical school research. Through this project, Sophia translated that lens into practical, clinically relevant TB care work. Household-centered TB prevention depends on understanding who patients actually consider part of their household and who they choose to disclose their diagnosis to. Their findings show that real-world households are dynamic networks rather than fixed residential units, which has direct implications for how LTBI screening, treatment, and support are delivered. This is especially important in diverse, migrant-rich settings where tr
aditional household definitions may miss key relationships.
Through her research experience, Sophia learned how differently qualitative and quantitative methods generate insight, and how essential both are for understanding health and disease. Working directly with patient narratives, diagrams, and lived experiences showed her how qualitative data provides context and meaning that large datasets often cannot capture alone. In contrast, earlier quantitative work using R to analyze area-based sociodemographic indices taught me how structured data can reveal population-level patterns, and together these experiences showed me the value of integrating multiple methods with strong mentorship guiding the process.
Sophia is currently preparing to present this household-focused project at the 2026 Medical Student Research Symposium.
Student Spotlight: Wei Ni Zhou, M2
Congratulations to Wei Ni Zhou, a current M2 and 2025 MSSRP researcher, on her recent selection to present her research, Medical Optimization of Patients with Intermittenet Claudication in A Safety-Net Hospital Setting, at the 53rd Annual Symposium on Vascualr Surgery in March 2026. Her research explores the disease progression and treatment adherence in patients with lower extremity claudication (pain with walking that subsides with rest) at Boston Medical Center. Under the mentorship of Dr. Jeffrey Siracuse and surgery resident Dr. Andrea Alonso, they did a retrospective study of patients who were diagnosed with intermittent claudication (IC) at BMC from 2018-2025 and collected data on their first four clinic visits for claudication. Demographics, comorbidities, medications, symptoms, lifestyle modifications, progression to tissue loss/rest pain, and interventions were recorded.
Wei Ni enjoyed learning about peripheral artery disease in my undergraduate biochemistry class and wanted to learn about it further in a research setting. She was interested in researching disease progression over time and seeing how impactful treatment adherence was -- especially in preventing progression to the point where one needs life changing interventions like a leg amputation.
Many patients with intermittent claudication are started on conservative therapies (such as smoking cessation, optimized medication use, and supervised exercise therapy). So far, there is limited data on how IC patients fare on these therapies long term, but this project offers insight on claudication progression in the setting of variable patient therapy adherence, comorbidities, and social determinants of health. Their research demonstrates that medical optimization for patients with IC in the safety-net setting is suboptimal and highlights the importance of continuing research in the following areas: how to decrease barriers for supervised exercise therapy, have better assessments of patients' walking ability, and increase smoking cessation.
Her research experience has taught her that she truly enjoys doing clinical research. Prior to medical school, Wei Ni did not have as much exposure to retrspective chart studies and is grateful to have the opportunities to dive and explore something unfamiliar. She also learned that she enjoys translating her databases into variables that can be statistically analyzed since it involves problem solving and simple coding on Excel -- both of which she notes she hasn't done in a while!
Mentor Spotlight: Daniel Roh, MD/PhD
Dr. Daniel Roh, MD, PhD, Assistant Professor in Surgery
Daniel Roh, MD, PhD, specializes in plastic and reconstructive surgery. His interest in research began in high school and solidified at the University of Pittsburgh School of Medicine through a formative summer mentorship, which led him to pursue MSTP training to integrate science with clinical care. He received his MD and PhD from the University of Pittsburgh School of Medicine Medical Scientist Training Program and went on to complete the Harvard Combined Plastic Surgery Training Program at Brigham and Women's Hospital. After completing plastic surgery residency while remaining engaged in research, I launched my independent research program at BU/BMC in November 2019, supported by pilot studies that seeded my initial grant funding. Dr. Roh’s clinical practice spans both re constructive surgery for trauma or cancer patients and cosmetic
Dr. Roh's research focuses on cellular responses to tissue injury and the mechanisms that govern effective tissue repair, with particular emphasis on how cellular senescence influences skin wound healing with aging. A major goal of his laboratory is to translate these insights into clinically actionable strategies, including senolytic and senescence-modulating therapies that may improve repair while limiting pathologic scarring. This work is highly collaborative and includes partnerships with engineers to study extracellular matrix dynamics, tissue mechanics, and biomaterial-informed approaches. By integrating single-cell and spatial analyses with preclinical and human models, his research aims to inform the design of senescence-targeted interventions and guide future clinical trials in wound healing and surgical recovery.
Medical students in my laboratory have contributed to projects spanning senescence biology, epigenetic regulation, and age-related wound repair, including Jack Crouch, Grace Shin, Jannat Dhillon, Joy Ha, Minsung Cho, Sydni Britton, and Kylie Tang. Their work has led to multiple peer-reviewed publications and national-level scholarly dissemination in journals focused on aging and cell biology. Dr. Roh's lab has also recently welcomed Rayna Magesh, who is leading spatial transcriptomic analyses to study how aging and cellular senescence influence wound healing, and he works closely with Katie Hohl, an MD-PhD student, on a translational project examining relaxin-based approaches to reduce pathologic scarring.
Dr. Roh on mentorship:
To me, mentorship is about cultivating curiosity, independence, and purpose. I strive to help trainees find their own entry point into a scientific question, transforming inquiry into ownership and sustained motivation. I view mentorship as collaborative in which I provide structure, opportunity, and guidance, allowing students to build confidence and develop their identities as future clinician-scientists. One of the most rewarding aspects of mentorship is seeing a student become genuinely excited by a new result and recognize its potential for discovery; when that spark appears, it signals a deep connection to the work and meaningful scientific growth.
I emphasize that consistent effort, curiosity, and persistence are what ultimately drive success. The most effective mentees approach their work with discipline and resilience, remaining engaged even when progress is slow or results are uncertain. When sustained hard work is paired with genuine interest in the questions being asked, meaningful and lasting impact in medicine and science naturally follows.
There are numerous medical student–led work from my laboratory has resulted in multiple peer-reviewed publications, including:
- Samdavid Thanapaul RJR, Shvedova M, Shin GH, Roh DS. Viewpoint: An insight into aging, senescence, and their impacts on wound healing. Advances in Geriatric Medicine and Research 2021;3(3):e210017. PMID: 34414398 PMCID: PMC8373038
- Crouch J, Shvedova M, Thanapaul RJRS, Botchkarev V, Roh D. Epigenetic Regulation of Cellular Senescence. Cells. 2022 Feb 15;11(4):672. doi: 10.3390/cells11040672. PMID: 35203320; PMCID: PMC8870565.
- Thanapaul RJRS, Shvedova M, Shin GH, Crouch J, Roh DS. “Elevated skin senescence in young mice causes delayed wound healing”. GeroScience. 2022 Jun;44(3):1871-1878. PMID: 35399134; PMCID: PMC9213596.
- Shvedova M, Thanapaul RJRS, Ha J, Dhillon J, Shin GH, Crouch J, Gower AC, Gritli S, Roh DS. Topical ABT-263 treatment reduces aged skin senescence and improves subsequent wound healing. Aging (Albany NY). 2024 Dec 3;16. doi: 10.18632/aging.206165. Epub ahead of print. PMID: 39630941. PMCID: PMC11810067.
In addition, students have presented their work through oral and poster presentations at multiple local, national, and international scientific meetings.
Mentor Spotlight: Vipul Chitalia, MD/PhD
Dr. Vipul Chitalia (MD PhD) is a physician-scientist and Professor in the Department of Medicine and an affiliate at the Institute of Medical Engineering and Science at MIT. He completed his internal medicine residency in a program with Columbia University, a renal fellowship at Boston University and a postdoc fellowship at Massachusetts Institute of Technology (MIT). His research is focused on the intersection of cardiovascular complications in different diseases. His reverse translational model has contributed to the fundamental understanding of cardiovascular diseases in patients with kidney failure and cancer.
As an MD-PhD, Dr. Chitalia’s primary goal is to help patients, particularly those he encounters through his clinical work at Boston Medical Center—a unique and diverse patient population. He applies a "bedside to bench" approach, bringing clinical challenges back to the lab for investigation. His postdoctoral experience at MIT, working with Nobel laureate Philip Sharp, Bob Langer, and Elazer Edelman reinforced his commitment to bridging patient care and research.
Since establishing his lab around 2011-2012, Dr. Chitalia has aimed to translate patient problems into research questions that can lead to meaningful therapies. He is passionate about nurturing the physician-scientist mindset, emphasizing that physicians—who intimately understand patient suffering and disease processes—are uniquely positioned to innovate new treatments. Without this perspective, he believes crucial insights into patient care might be missed.
Dr. Chitalia on mentorship:
For Dr. Chitalia, mentorship is a role that naturally emerges through the act of mentoring itself and is deeply rooted in his passion for giving back what he has gained. Reflecting on his own training, he was inspired by mentors during his residency and fellowship who encouraged him to think deeply about patients and to translate clinical problems into research questions that ultimately benefit patient care. He strives to pass on this “art of science” to his students.
His mentoring approach centers on making the scientific journey an enjoyable and meaningful experience. Dr. Chitalia spends time with his students everyday discussing hypotheses and emphasizes the importance of understanding the “why” behind their work, as this fosters greater enthusiasm and insight. To connect research with real-world impact, he also takes students on clinical rounds to witness firsthand how their scientific inquiries relate to patient care, reinforcing that even small contributions can have significant future impact. He views mentoring as an art that can only be learned by doing, and this hands-on, patient-centered approach defines his guidance to mentees.
Student Spotlight: Dr. Vipul Chitalia’s Lab (Anna Natrakul, Arjun Patel, Pranav Yadati, DJ Wu Wong)
Arjun Patel, M1 (2026 LEADS/MSSRP scholar) has been involved in several projects in Dr. Chitalia’s lab, notably researching the impact of semaglutide therapies on deep vein thrombosis. This project originated from one of Dr. Chitalia's clinical observations at Boston Medical Center, linking patient care directly to research. Their findings on the regulation of thrombotic factors have potential implications for clinical trials and regulatory review.
Joining the lab as an undergraduate with no prior lab experience, Arjun has grown significantly in knowledge and skills, supported by patient mentorship from Dr. Chitalia and guidance from fellow students. Initially unsure about nephrology, his experience has sparked a strong interest in internal medicine and the scientific investigation involved. The lab’s collaborative environment and variety of research roles have enriched his learning and development. His research is published in the Kidney360 journal, "Aryl Hydrocarbon Receptor Pathway Augments Peritoneal Fibrosis in a Murine CKD Model Exposed to Peritoneal."
Pranav Yadati, M1 (2026 LEADS/MSSRP scholar) graduated in 2020 and brings a diverse background including teaching high school math and clinical research. He completed his Medical Sciences Master's Program thesis in Dr. Chitalia’s lab, focusing on how kidney disease leads to muscle wasting, a common and debilitating issue for dialysis patients. He also contributed to research on calciphylaxis. Transitioning from rat-based studies and clinical research to more molecular bench work, Pranav appreciates the connection between patient care and laboratory investigation.
With a family history of kidney disease, his personal motivation drives his research interest in nephrology. Through his journey—overcoming initial setbacks in medical school applications—Pranav has developed perseverance and adaptability, learning to navigate the ups and downs of research. He values these skills as essential for both science and medicine.
DJ Wu Wong, M3, (2024 LEADS/MSSRP scholar) is another student in Dr. Chitalia's lab who recently presented at the ASN Conference. His project is on Intravascular Ultrasonography Demonstrates Accuracy over Angiography in Arteriovenous Hemodialysis Dysfunction." He an author on the article "Tryptophan metabolism reprogramming contributes to the prothrombotic milieu in mice and humans infected with SARS-CoV 2"was recently published. DJ's research investigates SARS-CoV-2 infection disturbs the coagulation balance in the blood, triggering thrombosis and contributing to organ failure.
Dr. Chitalia is recognized by his students as an exceptional mentor who consistently makes time for his students and is understanding of their schedules. He ensures that mentees contribute meaningfully to projects, fostering a positive and engaging research environment. His enthusiasm for involving medical students is genuine and evident. His students state Dr. Chitalia approaches setbacks with a constructive and optimistic mindset, viewing challenges as opportunities to pivot, learn, and grow. He actively involves students in collaborative discussions and networking, making the research experience feel dynamic and fast-paced. Beyond research, he invests deeply in his mentees’ personal and professional development, offering guidance on long-term goals like residency planning. His dedication and supportive attitude make him a highly valued role model.
One of Dr. Chitalia’s defining qualities is his positive and resilient approach to research challenges. Rather than viewing setbacks as failures, he encourages seeing them as opportunities to learn, adapt, and find new directions. He actively connects students with experts and collaborators, inviting them to participate in meetings and discussions that broaden their scientific understanding and networks. This inclusive approach makes the research process feel dynamic and fast-paced, counteracting the typical frustrations of slow progress, especially for busy medical students.
Importantly, Dr. Chitalia invests in the holistic development of his mentees beyond the lab. He offers personalized guidance on career planning, including early preparation for residency applications, and supports students regardless of whether their future lies within nephrology. His commitment to nurturing each person’s individual journey and interests, combined with his incredible work ethic and visionary planning, establishes him as not only a mentor but also a dedicated role model. Students deeply appreciate his unwavering support, positivity, and genuine care, which empower them to thrive both as researchers and future clinicians.
Student Spotlight: Isabelle Joy ‘ 28 – 2025 DoM Evans Days 1st Place Basic Science Poster Winner
We want to congratulate Isabelle Joy, the 2025 Boston University Department of Medicine Research Symposium 1st Place Basic Science Poster Winner! Isabelle was a 2025 MSSRP student mentored by Dr. Thomas Clarke and received support from The Grunebaum Cancer Research Foundation.What Isabelle and Samuel have learned through this research experience:
Isabelle: I gained a great appreciation for the field of molecular biology through this research. The meticulous dedication that is required to confirm a hypothesis is far beyond what I imagined, and I learned that I love the experience of taking a deep dive into a question and disproving all of my own counterarguments until I have a theory that is backed by solid evidence and foolproof logic. The satisfaction from that aspect of the work was certainly a pleasant surprise. This was my first experience presenting my research in a formal setting, and I had an absolute blast doing it. I also grew more confident in public speaking, fueled by my sheer excitement in the research findings.
Student Spotlight: Kylie Tang ‘ 28 – 2025 DoM Evans Days 3rd Place Basic Science Poster Winner
Congratulations to Kylie Tang, a current M2 student, the 2025 Boston University Department of Medicine Research Symposium 3rd place Basic Science Poster Winner! Under the mentorship of Dr. Daniel Roh, MD/PhD, Kylie presented her research project, "The Effects of Dasatinib + Quercetin on Open Wound repair in Aged and Youn Skin." This research project looked at senescence-related cutaneous wound healing and the influence of senolytics on it. They found that senolytics didn’t delay wound healing in young mice, and it significantly accelerated wound healing in aged mice to a comparable rate as young mice. Noting the varying gene expression of different senescence markers at the wound site indicate that there is more to be explored.
Kylie's inspiration and initial interest in the aging process was sparked by her undergrad research in neurotransmitter dynamics in Parkinson's. Over time, her interests shifted from studying diseases in neural degeneration to more of an interest in the entire body, such as the skin and regeneration abilities. She was excited and felt privileged to pursue this interest with the Roh lab, where they looked at senescence and its impact on tissue repair. She was also mentored by Dr. Maria Shvedova, MD/PhD and Dr. Qioaling Wang, PhD.
When asked about the importance and timeliness of her project, Kylie states "Today, our older population is larger than ever due to our advances in healthcare and technology. With this rapidly growing population comes increasing demands in age-related care and how we can tailor healthcare to older patients, which may differ from younger populations. Therefore, a better understanding of the impact of senescence on wound healing is crucial."
Through this experience, Kylie has gained valuable technical skills, enhanced critical thinking, and learned the importance of collaboration in scientific research. Through many trials and errors with the guidance and patience of her mentors, Kylie developed not only a greater array of skills but also the ability to think more critically, saying "I’m lucky to be part of a collaborative environment, and so I learned just how important it is to work together as a team."
We are so proud of Kylie for her ongoing accomplishments and the efforts of her mentor Dr. Roh, his lab and all those involved!