Sections
Nephrology
Biography
Expertise includes: Protein biochemistry; Signaling pathway study; Cell biology; Molecular genetics; Molecular nephrology; Neuroscience; and Pharmacology.
Education
MD, Zhejiang University
PhD, McGill University
MSc, McGill University
Publications
Kumar S, Fan X, Pattam H, Yan K, Liaw EJ, Ji J, Zaltz E, Song P, Jiang Y, Nishizaki Y, Higashi Y, Cai CL, Lu W. Transcription factor ZEB2 is essential for ureteral smooth muscle cell differentiation. PLoS Genet. 2026 Jan; 22(1):e1012028. PMID: 41576029.
Published on 2/25/2025Kumar S, Fan X, Pattam H, Yan K, Liaw EJ, Ji J, Zaltz E, Song P, Jiang Y, Nishizaki Y, Higashi Y, Cai CL, Lu W. ZEB2 signaling is essential for ureteral smooth muscle cell differentiation and maintenance. bioRxiv. 2025 Feb 25. PMID: 40060690.
Published on 1/16/2025Hayashi N, Kumar S, Trivin-Avillach C, Fan X, Stoddard SV, Akai R, Fujimoto K, Iwawaki T, Yokoyama H, Furuichi K, Beck LH. Characterization of FAM114A1: a novel podocyte cytoskeleton-associated protein upregulated in glomerular injury. Am J Physiol Renal Physiol. 2025 Feb 01; 328(2):F289-F299. PMID: 39819080.
Published on 3/24/2020Pisarek-Horowitz A, Fan X, Kumar S, Rasouly HM, Sharma R, Chen H, Coser K, Bluette CT, Hirenallur-Shanthappa D, Anderson SR, Yang H, Beck LH, Bonegio RG, Henderson JM, Berasi SP, Salant DJ, Lu W. Loss of Roundabout Guidance Receptor 2 (Robo2) in Podocytes Protects Adult Mice from Glomerular Injury by Maintaining Podocyte Foot Process Structure. Am J Pathol. 2020 04; 190(4):799-816. PMID: 32220420.
Published on 1/9/2018Tumelty KE, Higginson-Scott N, Fan X, Bajaj P, Knowlton KM, Shamashkin M, Coyle AJ, Lu W, Berasi SP. Identification of direct negative cross-talk between the SLIT2 and bone morphogenetic protein-Gremlin signaling pathways. J Biol Chem. 2018 03 02; 293(9):3039-3055. PMID: 29317497.
Published on 11/17/2016Fan X, Yang H, Kumar S, Tumelty KE, Pisarek-Horowitz A, Rasouly HM, Sharma R, Chan S, Tyminski E, Shamashkin M, Belghasem M, Henderson JM, Coyle AJ, Salant DJ, Berasi SP, Lu W. SLIT2/ROBO2 signaling pathway inhibits nonmuscle myosin IIA activity and destabilizes kidney podocyte adhesion. JCI Insight. 2016 11 17; 1(19):e86934. PMID: 27882344.
Published on 12/17/2015Zhang Y, Fan J, Ho JW, Hu T, Kneeland SC, Fan X, Xi Q, Sellarole MA, de Vries WN, Lu W, Lachke SA, Lang RA, John SW, Maas RL. Crim1 regulates integrin signaling in murine lens development. Development. 2016 Jan 15; 143(2):356-66. PMID: 26681494.
Published on 5/31/2015Hwang DY, Kohl S, Fan X, Vivante A, Chan S, Dworschak GC, Schulz J, van Eerde AM, Hilger AC, Gee HY, Pennimpede T, Herrmann BG, van de Hoek G, Renkema KY, Schell C, Huber TB, Reutter HM, Soliman NA, Stajic N, Bogdanovic R, Kehinde EO, Lifton RP, Tasic V, Lu W, Hildebrandt F. Mutations of the SLIT2-ROBO2 pathway genes SLIT2 and SRGAP1 confer risk for congenital anomalies of the kidney and urinary tract. Hum Genet. 2015 Aug; 134(8):905-16. PMID: 26026792.
Published on 1/7/2015Quintero-Rivera F, Xi QJ, Keppler-Noreuil KM, Lee JH, Higgins AW, Anchan RM, Roberts AE, Seong IS, Fan X, Lage K, Lu LY, Tao J, Hu X, Berezney R, Gelb BD, Kamp A, Moskowitz IP, Lacro RV, Lu W, Morton CC, Gusella JF, Maas RL. MATR3 disruption in human and mouse associated with bicuspid aortic valve, aortic coarctation and patent ductus arteriosus. Hum Mol Genet. 2015 Apr 15; 24(8):2375-89. PMID: 25574029.
Published on 7/12/2012Fan X, Li Q, Pisarek-Horowitz A, Rasouly HM, Wang X, Bonegio RG, Wang H, McLaughlin M, Mangos S, Kalluri R, Holzman LB, Drummond IA, Brown D, Salant DJ, Lu W. Inhibitory effects of Robo2 on nephrin: a crosstalk between positive and negative signals regulating podocyte structure. Cell Rep. 2012 Jul 26; 2(1):52-61. PMID: 22840396.