Victoria M. Bolotina PhD

Professor, Vascular Biology

Research Professor, Physiology & Biophysics

650 Albany St | (617) 638-7118
Victoria Bolotina
Sections

Vascular Biology

Centers

Whitaker Cardiovascular Institute

Evans Center for Interdisciplinary Biomedical Research

Biography

Dr. Bolotina, Ph.D., is a leading expert in Calcium signaling and ion channels (with over 2000 citations of her work), who is well funded by NIH. The focus of her research is on the molecular mechanisms of Calcium entry and its role in physiological and pathological function.

Other Positions

Education

PhD, Moscow State University, 1984

BSc, Moscow State University, 1980

Publications

Published on 6/1/2016

Cohen RA, Murdoch CE, Watanabe Y, Bolotina VM, Evangelista AM, Haeussler DJ, Smith MD, Mei Y, Tong X, Han J, Behring JB, Bachschmid MM, Matsui R. Endothelial Cell Redox Regulation of Ischemic Angiogenesis. J Cardiovasc Pharmacol. 2016 Jun; 67(6):458-64. PMID: 26927696.

Published on 1/12/2016

Zhou Q, Yen A, Rymarczyk G, Asai H, Trengrove C, Aziz N, Kirber MT, Mostoslavsky G, Ikezu T, Wolozin B, Bolotina VM. Impairment of PARK14-dependent Ca(2+) signalling is a novel determinant of Parkinson's disease. Nat Commun. 2016; 7:10332. PMID: 26755131.

Published on 6/11/2014

Thompson MD, Mei Y, Weisbrod RM, Silver M, Shukla PC, Bolotina VM, Cohen RA, Tong X. Glutathione adducts on sarcoplasmic/endoplasmic reticulum Ca2+ ATPase Cys-674 regulate endothelial cell calcium stores and angiogenic function as well as promote ischemic blood flow recovery. J Biol Chem. 2014 Jul 18; 289(29):19907-16. PMID: 24920669.

Published on 10/23/2012

Evangelista AM, Thompson MD, Bolotina VM, Tong X, Cohen RA. Nox4- and Nox2-dependent oxidant production is required for VEGF-induced SERCA cysteine-674 S-glutathiolation and endothelial cell migration. Free Radic Biol Med. 2012 Dec 15; 53(12):2327-34. PMID: 23089226.

Published on 10/5/2012

Schäfer C, Rymarczyk G, Ding L, Kirber MT, Bolotina VM. Role of molecular determinants of store-operated Ca(2+) entry (Orai1, phospholipase A2 group 6, and STIM1) in focal adhesion formation and cell migration. J Biol Chem. 2012 Nov 23; 287(48):40745-57. PMID: 23043102.

Published on 5/31/2012

Evangelista AM, Thompson MD, Weisbrod RM, Pimental DR, Tong X, Bolotina VM, Cohen RA. Redox regulation of SERCA2 is required for vascular endothelial growth factor-induced signaling and endothelial cell migration. Antioxid Redox Signal. 2012 Oct 15; 17(8):1099-108. PMID: 22472004.

Published on 5/1/2012

Bolotina VM. Orai1, STIM1, and iPLA2ß determine arterial vasoconstriction. Arterioscler Thromb Vasc Biol. 2012 May; 32(5):1066-7. PMID: 22517361.

Published on 5/1/2012

Gwozdz T, Dutko-Gwozdz J, Schafer C, Bolotina VM. Overexpression of Orai1 and STIM1 proteins alters regulation of store-operated Ca2+ entry by endogenous mediators. J Biol Chem. 2012 Jun 29; 287(27):22865-72. PMID: 22549787.

Published on 11/16/2011

Yang B, Gwozdz T, Dutko-Gwozdz J, Bolotina VM. Orai1 and Ca2+-independent phospholipase A2 are required for store-operated Icat-SOC current, Ca2+ entry, and proliferation of primary vascular smooth muscle cells. Am J Physiol Cell Physiol. 2012 Mar 1; 302(5):C748-56. PMID: 22094335.

Published on 9/3/2008

Gwozdz T, Dutko-Gwozdz J, Zarayskiy V, Peter K, Bolotina VM. How strict is the correlation between STIM1 and Orai1 expression, puncta formation, and ICRAC activation? Am J Physiol Cell Physiol. 2008 Nov; 295(5):C1133-40. PMID: 18768920.

View full list of 40 publications.