Tyler Steven Brown MD
Assistant Professor, Infectious Diseases
801 Massachusetts Ave | (617) 638-8052tsbrown@bu.edu
Sections
Infectious Diseases
Biography
Tyler Brown is an infectious disease physician, epidemiologist, and Assistant Professor in the Section of Infectious Diseases. His scientific work uses phylogenomics, population genetics, and mathematical modeling to understand how microbial evolution, human host mobility, and other factors shape the transmission and geographic dispersal of tuberculosis and other infectious diseases.
Selected publications (full list available on the Publications tab of this profile):
Brown TS*, Tang L*, Omar SV, Joseph L, Meintjes G, Maartens G, Wasserman S, Shah NS, Farhat MR, Gandhi NR, Ismail N, Brust JCM, Mathema B. Genotype-Phenotype Characterization of Serial Mycobacterium tuberculosis Isolates in Bedaquiline-Resistant Tuberculosis. Clin Infect Dis. 2023 Oct 24. PMID: 37874928; DOI: 10.1093/cid/ciad596 (*co-first authors)
Brown TS, Robinson DA, Buckee CO, Mathema B. Connecting the dots: understanding how human mobility shapes TB epidemics. Trends Microbiol. 2022 Nov; 30(11):1036-1044. PMID: 35597716; PMCID: PMC10068677; DOI: 10.1016/j.tim.2022.04.005
Brown TS, Arogbokun O, Buckee CO, Chang HH. Distinguishing gene flow between malaria parasite populations. PLoS Genet. 2021 Dec; 17(12):e1009335. PMID: 34928954; PMCID: PMC8726502; DOI: 10.1371/journal.pgen.1009335
Brown TS, Eldholm V, Brynildsrud O, Osnes M, Levy N, Stimson J, Colijn C, Alexandru S, Noroc E, Ciobanu N, Crudu V, Cohen T, Mathema B. Evolution and emergence of multidrug-resistant Mycobacterium tuberculosis in Chisinau, Moldova. Microb Genom. 2021 Aug; 7(8). PMID: 34431762; PMCID: PMC8549355; DOI: 10.1099/mgen.0.000620
Brown TS, Engø-Monsen K, Kiang MV, Mahmud AS, Maude RJ, Buckee CO. The impact of mobility network properties on predicted epidemic dynamics in Dhaka and Bangkok. Epidemics. 2021 Jun; 35:100441. PMID: 33667878; PMCID: PMC7899011; DOI: 10.1016/j.epidem.2021.100441
Brown TS, Challagundla L, Baugh EH, Omar SV, Mustaev A, Auld SC, Shah NS, Kreiswirth BN, Brust JCM, Nelson KN, Narechania A, Kurepina N, Mlisana K, Bonneau R, Eldholm V, Ismail N, Kolokotronis SO, Robinson DA, Gandhi NR, Mathema B. Pre-detection history of extensively drug-resistant tuberculosis in KwaZulu-Natal, South Africa. Proc Natl Acad Sci U S A. 2019 Nov 12; 116(46):23284-23291. PMID: 31659018; PMCID: PMC6859317; DOI: 10.1073/pnas.1906636116
Shah NS, Auld SC, Brust JC, Mathema B, Ismail N, Moodley P, Mlisana K, Allana S, Campbell A, Mthiyane T, Morris N, Mpangase P, van der Meulen H, Omar SV, Brown TS, Narechania A, Shaskina E, Kapwata T, Kreiswirth B, Gandhi NR. Transmission of Extensively Drug-Resistant Tuberculosis in South Africa. N Engl J Med. 2017 Jan 19; 376(3):243-253. PMID: 28099825; PMCID: PMC5330208; DOI: 10.1056/NEJMoa1604544
Education
MD, Johns Hopkins University School of Medicine
Chemistry, AB, Princeton University
Publications
Brown TS, Tang L, Omar SV, Joseph L, Meintjes G, Maartens G, Wasserman S, Shah NS, Farhat MR, Gandhi NR, Ismail N, Brust JCM, Mathema B. Genotype-Phenotype Characterization of Serial Mycobacterium tuberculosis Isolates in Bedaquiline-Resistant Tuberculosis. Clin Infect Dis. 2024 Feb 17; 78(2):269-276. PMID: 37874928.
Published on 4/3/2023Mohareb AM, Brown TS. Medical Student Debt and the US Infectious Diseases Workforce. Clin Infect Dis. 2023 Apr 03; 76(7):1322-1327. PMID: 36318609.
Published on 3/7/2023Brown T, de Salazar Munoz PM, Bhatia A, Bunda B, Williams EK, Bor D, Miller JS, Mohareb A, Thierauf J, Yang W, Villalba J, Naranbai V, Garcia Beltran W, Miller TE, Kress D, Stelljes K, Johnson K, Larremore D, Lennerz J, Iafrate AJ, Balsari S, Buckee C, Grad Y. Geographically skewed recruitment and COVID-19 seroprevalence estimates: a cross-sectional serosurveillance study and mathematical modelling analysis. BMJ Open. 2023 Mar 07; 13(3):e061840. PMID: 36882240.
Published on 5/18/2022Brown TS, Robinson DA, Buckee CO, Mathema B. Connecting the dots: understanding how human mobility shapes TB epidemics. Trends Microbiol. 2022 Nov; 30(11):1036-1044. PMID: 35597716.
Published on 12/20/2021Brown TS, Arogbokun O, Buckee CO, Chang HH. Distinguishing gene flow between malaria parasite populations. PLoS Genet. 2021 Dec; 17(12):e1009335. PMID: 34928954.
Published on 12/16/2021Dugdale CM, Rubins DM, Lee H, McCluskey SM, Ryan ET, Kotton CN, Hurtado RM, Ciaranello AL, Barshak MB, McEvoy DS, Nelson SB, Basgoz N, Lazarus JE, Ivers LC, Reedy JL, Hysell KM, Lemieux JE, Heller HM, Dutta S, Albin JS, Brown TS, Miller AL, Calderwood SB, Walensky RP, Zachary KC, Hooper DC, Hyle EP, Shenoy ES. Coronavirus Disease 2019 (COVID-19) Diagnostic Clinical Decision Support: A Pre-Post Implementation Study of CORAL (COvid Risk cALculator). Clin Infect Dis. 2021 Dec 16; 73(12):2248-2256. PMID: 33564833.
Published on 8/1/2021Brown TS, Eldholm V, Brynildsrud O, Osnes M, Levy N, Stimson J, Colijn C, Alexandru S, Noroc E, Ciobanu N, Crudu V, Cohen T, Mathema B. Evolution and emergence of multidrug-resistant Mycobacterium tuberculosis in Chisinau, Moldova. Microb Genom. 2021 Aug; 7(8). PMID: 34431762.
Published on 3/22/2021Salje H, Wesolowski A, Brown TS, Kiang MV, Berry IM, Lefrancq N, Fernandez S, Jarman RG, Ruchusatsawat K, Iamsirithaworn S, Vandepitte WP, Suntarattiwong P, Read JM, Klungthong C, Thaisomboonsuk B, Engø-Monsen K, Buckee C, Cauchemez S, Cummings DAT. Reconstructing unseen transmission events to infer dengue dynamics from viral sequences. Nat Commun. 2021 Mar 22; 12(1):1810. PMID: 33753725.
Published on 2/22/2021Brown TS, Engø-Monsen K, Kiang MV, Mahmud AS, Maude RJ, Buckee CO. The impact of mobility network properties on predicted epidemic dynamics in Dhaka and Bangkok. Epidemics. 2021 Jun; 35:100441. PMID: 33667878.
Published on 10/8/2020Brown TS, Dubowski K, Plitt M, Falci L, Lee E, Huynh M, Furuya Y, Vora NM. Erroneous Reporting of Deaths Attributed to Pneumonia and Influenza at 2 New York City Teaching Hospitals, 2013-2014. Public Health Rep. 2020; 135(6):796-804. PMID: 33031711.