Tyler Steven Brown MD
Assistant Professor, Infectious Diseases
801 Massachusetts Ave | (617) 638-8052tsbrown@bu.edu
Sections
Infectious Diseases
Biography
Tyler Brown is an infectious disease physician, epidemiologist, and Assistant Professor in the Section of Infectious Diseases. His scientific work uses phylogenomics, population genetics, and mathematical modeling to understand how microbial evolution, human host mobility, and other factors shape the transmission and geographic dispersal of tuberculosis and other infectious diseases.
Selected publications (full list available on the Publications tab of this profile):
Brown TS*, Tang L*, Omar SV, Joseph L, Meintjes G, Maartens G, Wasserman S, Shah NS, Farhat MR, Gandhi NR, Ismail N, Brust JCM, Mathema B. Genotype-Phenotype Characterization of Serial Mycobacterium tuberculosis Isolates in Bedaquiline-Resistant Tuberculosis. Clin Infect Dis. 2023 Oct 24. PMID: 37874928; DOI: 10.1093/cid/ciad596 (*co-first authors)
Brown TS, Robinson DA, Buckee CO, Mathema B. Connecting the dots: understanding how human mobility shapes TB epidemics. Trends Microbiol. 2022 Nov; 30(11):1036-1044. PMID: 35597716; PMCID: PMC10068677; DOI: 10.1016/j.tim.2022.04.005
Brown TS, Arogbokun O, Buckee CO, Chang HH. Distinguishing gene flow between malaria parasite populations. PLoS Genet. 2021 Dec; 17(12):e1009335. PMID: 34928954; PMCID: PMC8726502; DOI: 10.1371/journal.pgen.1009335
Brown TS, Eldholm V, Brynildsrud O, Osnes M, Levy N, Stimson J, Colijn C, Alexandru S, Noroc E, Ciobanu N, Crudu V, Cohen T, Mathema B. Evolution and emergence of multidrug-resistant Mycobacterium tuberculosis in Chisinau, Moldova. Microb Genom. 2021 Aug; 7(8). PMID: 34431762; PMCID: PMC8549355; DOI: 10.1099/mgen.0.000620
Brown TS, Engø-Monsen K, Kiang MV, Mahmud AS, Maude RJ, Buckee CO. The impact of mobility network properties on predicted epidemic dynamics in Dhaka and Bangkok. Epidemics. 2021 Jun; 35:100441. PMID: 33667878; PMCID: PMC7899011; DOI: 10.1016/j.epidem.2021.100441
Brown TS, Challagundla L, Baugh EH, Omar SV, Mustaev A, Auld SC, Shah NS, Kreiswirth BN, Brust JCM, Nelson KN, Narechania A, Kurepina N, Mlisana K, Bonneau R, Eldholm V, Ismail N, Kolokotronis SO, Robinson DA, Gandhi NR, Mathema B. Pre-detection history of extensively drug-resistant tuberculosis in KwaZulu-Natal, South Africa. Proc Natl Acad Sci U S A. 2019 Nov 12; 116(46):23284-23291. PMID: 31659018; PMCID: PMC6859317; DOI: 10.1073/pnas.1906636116
Shah NS, Auld SC, Brust JC, Mathema B, Ismail N, Moodley P, Mlisana K, Allana S, Campbell A, Mthiyane T, Morris N, Mpangase P, van der Meulen H, Omar SV, Brown TS, Narechania A, Shaskina E, Kapwata T, Kreiswirth B, Gandhi NR. Transmission of Extensively Drug-Resistant Tuberculosis in South Africa. N Engl J Med. 2017 Jan 19; 376(3):243-253. PMID: 28099825; PMCID: PMC5330208; DOI: 10.1056/NEJMoa1604544
Education
MD, Johns Hopkins University School of Medicine
Chemistry, AB, Princeton University
Publications
Sobol R, Omar SV, Brown T, Joseph L, Lutchminarian K, Tang L, Lan Y, Willis F, Campbell A, Warren JL, Cohen T, Brust JCM, Naidoo K, Shah NS, Gandhi NR, Mathema B. Transmission of Bedaquiline-resistant Mycobacterium tuberculosis in KwaZulu-Natal, South Africa. Am J Respir Crit Care Med. 2025 Sep 30. PMID: 41026808.
Published on 9/12/2025Menzies NA, Brown TS, Imai-Eaton JW, Dodd PJ, Cohen T, Martinez L. Potential paediatric tuberculosis incidence and deaths resulting from interruption in programmes supported by international health aid, 2025-34: a mathematical modelling study. Lancet Child Adolesc Health. 2025 Nov; 9(11):787-795. PMID: 40953585.
Published on 6/1/2025Begemann D, Alonso C, Bates S, Ryan ET, Walker AT, Keppard B, Kissel AM, Amaya F, Rao SR, Brown TS, Mohareb AM, Levison JH, LaRocque RC. Work-related connectivity between Boston Logan international airport and urban communities with high social vulnerability during the COVID-19 pandemic. Trop Dis Travel Med Vaccines. 2025 Jun 01; 11(1):15. PMID: 40450310.
Published on 4/11/2025Lan Y, Rancu I, Chitwood MH, Sobkowiak B, Nyhan K, Lin HH, Wu CY, Mathema B, Brown TS, Colijn C, Warren JL, Cohen T. Integrating genomic and spatial analyses to describe tuberculosis transmission: a scoping review. Lancet Microbe. 2025 Aug; 6(8):101094. PMID: 40228509.
Published on 5/30/2024Mohareb AM, Deukmejian M, Guerra Castillo C, Brown TS, LaRocque R, Taveras E, Sarin Gupta P. School-Based Mobile Clinics to Improve Vaccine Access: A Cross-sectional Study of COVID-19 Vaccination. J Pediatric Infect Dis Soc. 2024 May 30; 13(5):274-275. PMID: 38587478.
Published on 2/17/2024Brown TS, Tang L, Omar SV, Joseph L, Meintjes G, Maartens G, Wasserman S, Shah NS, Farhat MR, Gandhi NR, Ismail N, Brust JCM, Mathema B. Genotype-Phenotype Characterization of Serial Mycobacterium tuberculosis Isolates in Bedaquiline-Resistant Tuberculosis. Clin Infect Dis. 2024 Feb 17; 78(2):269-276. PMID: 37874928.
Published on 12/1/2023Brown TS, Mohareb AM, LaRocque RC. Universal Masking in Health Care Settings. Ann Intern Med. 2023 Dec; 176(12):eL230347. PMID: 38109751.
Published on 4/3/2023Mohareb AM, Brown TS. Medical Student Debt and the US Infectious Diseases Workforce. Clin Infect Dis. 2023 Apr 03; 76(7):1322-1327. PMID: 36318609.
Published on 3/7/2023Brown T, de Salazar Munoz PM, Bhatia A, Bunda B, Williams EK, Bor D, Miller JS, Mohareb A, Thierauf J, Yang W, Villalba J, Naranbai V, Garcia Beltran W, Miller TE, Kress D, Stelljes K, Johnson K, Larremore D, Lennerz J, Iafrate AJ, Balsari S, Buckee C, Grad Y. Geographically skewed recruitment and COVID-19 seroprevalence estimates: a cross-sectional serosurveillance study and mathematical modelling analysis. BMJ Open. 2023 Mar 07; 13(3):e061840. PMID: 36882240.
Published on 5/18/2022Brown TS, Robinson DA, Buckee CO, Mathema B. Connecting the dots: understanding how human mobility shapes TB epidemics. Trends Microbiol. 2022 Nov; 30(11):1036-1044. PMID: 35597716.