Stefano Monti PhD

Professor, Computational Biomedicine

Associate Professor, Biostatistics

75 E. Newton St | (617) 414-7031
smonti@bu.edu

Sections

Computational Biomedicine

Centers

BU-BMC Cancer Center

Evans Center for Interdisciplinary Biomedical Research

Biography

Stefano Monti is a Computational Biologist and joined the BU faculty in January 2011 in the section of Computational Biomedicine, with joint appointments in the Biostatistics Department and the Bioinformatics program. Monti received his Ph.D. in Intelligent Systems and Artificial Intelligence from the University of Pittsburgh, and completed his training with a post-doctoral fellowship at the Robotics Institute at Carnegie Mellon. His doctoral and post-doctoral research focused on the development of machine learning and knowledge discovery methodologies, with a particular emphasis on probabilistic reasoning and Bayesian approaches to modeling biomedical data. Since 2001, he has worked in the field of Cancer Genomics, first as a Research Scientist at the Whitehead Institute’s Center for Genome Research, and later as a Computational Biologist in the Cancer Program at the Broad Institute.

Dr. Monti's laboratory integrates systems biology, machine learning, and bioinformatics approaches to investigate the molecular drivers of human disease, with the goals of advancing prevention and care. This multidisciplinary effort relies on the development of novel computational methodologies, and on the design of experiments based on the generation and integrative analysis of high-throughput multi-omics data, with the goal of identifying novel therapeutic targets and developing accurate diagnostic and prognostic biomarkers. Specific areas of research include the study of the molecular mechanisms of tumor initiation and progression and of the role played in it by environmental exposure, as well as the study of the biological factors contributing to healthy aging and extreme longevity.

Other Positions

Websites

BU Profile

Department of Medicine Faculty

Twitter

Researchgate

Education

Artificial Intelligence, PhD, University of Pittsburgh

Artificial Intelligence, MS, University of Pittsburgh

Computer Science, MS, University of Houston

Computer Science, BS, Università degli Studi di Udine

Publications

Published on 8/26/2025

Ennis CS, Seen M, Chen A, Kang H, Ilinski A, Mahdaviani K, Ko NY, Monti S, Denis GV. Plasma exosomes from individuals with type 2 diabetes drive breast cancer aggression in patient-derived organoids. Commun Biol. 2025 Aug 26; 8(1):1276. PMID: 40858992.

PubMed

Published on 7/18/2025

Li M, Song Z, Reed E, Karagiannis TT, Andersen S, Brent M, Mateusiak C, Acharya S, Jung WS, Liao S, Wojczynski MK, Feitosa MF, O'Connell JR, Montasser ME, Thorpe RJ, Arbeev K, Milman S, Tai A, Perls TT, Sebastiani P, Monti S. Whole blood transcriptional signatures of age and survival identified in Long Life Family and Integrative Longevity Omics Studies. bioRxiv. 2025 Jul 18. PMID: 40791342.

PubMed

Published on 7/9/2025

Llévenes P, Chen A, Lawton M, Rondón-Ortiz AN, Qiu Y, Seen M, Monti S, Denis GV. Plasma exosomes in insulin resistant obesity exacerbate progression of triple negative breast cancer. BMC Cancer. 2025 Jul 09; 25(1):1089. PMID: 40629272.

PubMed

Published on 7/7/2025

Li W, Nishino M, Reed E, Akshinthala D, Pasha HA, Anderson ES, Huang L, Hebestreit H, Monti S, Gomez ED, Jalisi SM, Muthuswamy SK. Head and neck tumor organoid grown under simplified media conditions model tumor biology and chemoradiation responses. Sci Rep. 2025 Jul 07; 15(1):24221. PMID: 40624315.

PubMed

Published on 7/3/2025

Trepicchio C, Rauner G, Traugh N, Wang R, Parrish M, Fein DEC, Mal Y, Gupta PB, Monti S, Kuperwasser C. DDR1 regulates RUNX1-CBFß to control breast stem cell differentiation. Stem Cell Reports. 2025 Aug 12; 20(8):102576. PMID: 40614729.

PubMed

Published on 7/3/2025

Song Z, Gunn S, Monti S, Peloso GM, Liu CT, Lunetta K, Sebastiani P. Learning Gaussian Graphical Models from Correlated Data. Front Syst Biol. 2025; 5. PMID: 40766210.

PubMed

Published on 6/3/2025

Qiu Y, Chen A, Yu R, Llevenes P, Seen M, Ko NY, Monti S, Denis GV. Insulin Resistance Increases TNBC Aggressiveness and Brain Metastasis via Adipocyte-Derived Exosomes. Mol Cancer Res. 2025 Jun 03; 23(6):567-578. PMID: 40047645.

PubMed

Published on 5/28/2025

Sebastiani P, Reed E, Chandler KB, Lopez P, Lords H, Bae H, Costello CE, Au M, Deng LL, Li M, Xiang Q, Noh H, Pflieger L, Funk C, Rappaport N, Nygaard M, Short MI, Brent M, Monti S, Andersen SL, Perls TT. Robust Serum Proteomic Signatures of APOE2. bioRxiv. 2025 May 28. PMID: 40501769.

PubMed

Published on 5/3/2025

Chen AD, Kroehling L, Ennis C, Denis GV, Monti S. A highly resolved integrated transcriptomic atlas of human breast cancers. bioRxiv. 2025 May 03. PMID: 40161579.

PubMed

Published on 4/7/2025

Rogina B, Anderson R, LeBrasseur NK, Curran SP, Yousefzadeh MJ, Ghosh B, Duque G, Howlett S, Austad S, Demuth I, Gerstorf D, Korfhage J, Lombard DB, Abadir P, Christensen K, Carey JR, Alberts SC, Campos F, Palavicini JP, Palmer A, Bell J, Basisty N, de Cabo R, Gomes A, Dixit VD, Sen P, Baur JA, Imai SI, Li X, Valdez G, Orr ME, Pletcher S, Andersen J, Jones L, Castillo-Azofeida D, Bonaguidi M, Suh Y, Duncan FE, Murray A, Wang MC, Burkewitz K, Henne M, Zhou K, Bouhrara M, Benjamini D, Kolind S, Walker KA, Reiter DA, Dean DC, Gorbunova V, Gladyshev VN, Palovics R, Niedernhofer LJ, Fan R, Bueckle AD, Hurley J, Esser KA, Kapahi P, Sato S, Jiang N, Ashiqueali SA, Diaz J, Mishra SP, Raimundo N, Banarjee R, Allsopp R, Reynolds LM, Zhang B, Sebastiani P, Monti S, Schork N, Rappaport N. Symposia Report of The Annual Biological Sciences Section Meeting of the Gerontological Society of America 2023, Tampa, Florida. J Gerontol A Biol Sci Med Sci. 2025 Apr 07; 80(5). PMID: 39932386.

PubMed

View full list of 159 publications.