Stefano Monti PhD

Professor, Computational Biomedicine

Associate Professor, Biostatistics

75 E. Newton St | (617) 414-7031
Stefano Monti
Sections

Computational Biomedicine

Centers

BU-BMC Cancer Center

Evans Center for Interdisciplinary Biomedical Research

Biography

Stefano Monti is a Computational Biologist and joined the BU faculty in January 2011 in the section of Computational Biomedicine, with joint appointments in the Biostatistics Department and the Bioinformatics program. Monti received his Ph.D. in Intelligent Systems and Artificial Intelligence from the University of Pittsburgh, and completed his training with a post-doctoral fellowship at the Robotics Institute at Carnegie Mellon. His doctoral and post-doctoral research focused on the development of machine learning and knowledge discovery methodologies, with a particular emphasis on probabilistic reasoning and Bayesian approaches to modeling biomedical data. Since 2001, he has worked in the field of Cancer Genomics, first as a Research Scientist at the Whitehead Institute’s Center for Genome Research, and later as a Computational Biologist in the Cancer Program at the Broad Institute.

Dr. Monti's laboratory integrates systems biology, machine learning, and bioinformatics approaches to investigate the molecular drivers of human disease, with the goals of advancing prevention and care. This multidisciplinary effort relies on the development of novel computational methodologies, and on the design of experiments based on the generation and integrative analysis of high-throughput multi-omics data, with the goal of identifying novel therapeutic targets and developing accurate diagnostic and prognostic biomarkers. Specific areas of research include the study of the molecular mechanisms of tumor initiation and progression and of the role played in it by environmental exposure, as well as the study of the biological factors contributing to healthy aging and extreme longevity.

Other Positions

Education

Artificial Intelligence, PhD, University of Pittsburgh

Artificial Intelligence, MS, University of Pittsburgh

Computer Science, MS, University of Houston

Computer Science, BS, Università degli Studi di Udine

Publications

Published on 11/5/2024

Sebastiani P, Monti S, Lustgarten MS, Song Z, Ellis D, Tian Q, Schwaiger-Haber M, Stancliffe E, Leshchyk A, Short MI, Ardisson Korat AV, Gurinovich A, Karagiannis T, Li M, Lords HJ, Xiang Q, Marron MM, Bae H, Feitosa MF, Wojczynski MK, O'Connell JR, Montasser ME, Schupf N, Arbeev K, Yashin A, Schork N, Christensen K, Andersen SL, Ferrucci L, Rappaport N, Perls TT, Patti GJ. Metabolite signatures of chronological age, aging, survival, and longevity. Cell Rep. 2024 Nov 26; 43(11):114913. PMID: 39504246.

Published on 10/12/2024

Llevenes P, Chen A, Lawton M, Qiu Y, Seen M, Monti S, Denis GV. Plasma Exosomes in Insulin Resistant Obesity Exacerbate Progression of Triple Negative Breast Cancer. bioRxiv. 2024 Oct 12. PMID: 39416125.

Published on 9/19/2024

Ennis CS, Seen M, Chen A, Kang H, Ilinski A, Mahdaviani K, Ko N, Monti S, Denis GV. Plasma exosomes from individuals with type 2 diabetes drive breast cancer aggression in patient-derived organoids. bioRxiv. 2024 Sep 19. PMID: 39345362.

Published on 8/13/2024

Snyder M, Wang Z, Lara B, Fimbres J, Pichardo T, Mazzilli S, Khan MM, Duggineni VK, Monti S, Sherr DH. The Aryl Hydrocarbon Receptor Controls IFN?-Induced Immune Checkpoints PD-L1 and IDO via the JAK/STAT Pathway in Lung Adenocarcinoma. bioRxiv. 2024 Aug 13. PMID: 39185148.

Published on 7/25/2024

Reed ER, Chandler KB, Lopez P, Costello CE, Andersen SL, Perls TT, Li M, Bae H, Soerensen M, Monti S, Sebastiani P. Cross-platform proteomics signatures of extreme old age. Geroscience. 2024 Jul 25. PMID: 39048883.

Published on 6/4/2024

Li M, Song Z, Gurinovich A, Schork N, Sebastiani P, Monti S. yQTL Pipeline: A structured computational workflow for large scale quantitative trait loci discovery and downstream visualization. PLoS One. 2024; 19(6):e0298501. PMID: 38833463.

Published on 5/2/2024

Qiu Y, Chen A, Yu R, Llevenes P, Seen M, Ko NY, Monti S, Denis GV. Insulin Resistance Increases TNBC Aggressiveness and Brain Metastasis via Adipocyte-derived Exosomes. bioRxiv. 2024 May 02. PMID: 38746141.

Published on 4/14/2024

Reed ER, Chandler KB, Lopez P, Costello CE, Andersen SL, Perls TT, Li M, Bae H, Soerensen M, Monti S, Sebastiani P. Cross-platform proteomics signatures of extreme old age. bioRxiv. 2024 Apr 14. PMID: 38645061.

Published on 4/5/2024

Song Z, Gunn S, Monti S, Peloso GM, Liu CT, Lunetta K, Sebastiani P. Learning Gaussian Graphical Models from Correlated Data. bioRxiv. 2024 Apr 05. PMID: 38617340.

Published on 3/7/2024

Don J, Schork AJ, Glusman G, Rappaport N, Cummings SR, Duggan D, Raju A, Hellberg KG, Gunn S, Monti S, Perls T, Lapidus J, Goetz LH, Sebastiani P, Schork NJ. The relationship between 11 different polygenic longevity scores, parental lifespan, and disease diagnosis in the UK Biobank. Geroscience. 2024 Aug; 46(4):3911-3927. PMID: 38451433.

View full list of 144 publications.