Stefano Monti PhD
Professor, Computational Biomedicine
Associate Professor, Biostatistics
75 E. Newton St | (617) 414-7031smonti@bu.edu
Sections
Computational Biomedicine
Centers
BU-BMC Cancer Center
Evans Center for Interdisciplinary Biomedical Research
Biography
Stefano Monti is a Computational Biologist and joined the BU faculty in January 2011 in the section of Computational Biomedicine, with joint appointments in the Biostatistics Department and the Bioinformatics program. Monti received his Ph.D. in Intelligent Systems and Artificial Intelligence from the University of Pittsburgh, and completed his training with a post-doctoral fellowship at the Robotics Institute at Carnegie Mellon. His doctoral and post-doctoral research focused on the development of machine learning and knowledge discovery methodologies, with a particular emphasis on probabilistic reasoning and Bayesian approaches to modeling biomedical data. Since 2001, he has worked in the field of Cancer Genomics, first as a Research Scientist at the Whitehead Institute’s Center for Genome Research, and later as a Computational Biologist in the Cancer Program at the Broad Institute.
Dr. Monti's laboratory integrates systems biology, machine learning, and bioinformatics approaches to investigate the molecular drivers of human disease, with the goals of advancing prevention and care. This multidisciplinary effort relies on the development of novel computational methodologies, and on the design of experiments based on the generation and integrative analysis of high-throughput multi-omics data, with the goal of identifying novel therapeutic targets and developing accurate diagnostic and prognostic biomarkers. Specific areas of research include the study of the molecular mechanisms of tumor initiation and progression and of the role played in it by environmental exposure, as well as the study of the biological factors contributing to healthy aging and extreme longevity.
Other Positions
Education
Artificial Intelligence, PhD, University of Pittsburgh
Artificial Intelligence, MS, University of Pittsburgh
Computer Science, MS, University of Houston
Computer Science, BS, Università degli Studi di Udine
Publications
Monti S, Lustgarten MS, Huang Z, Song Z, Li M, Ellis D, Tian Q, Ferrucci L, Rappaport N, Andersen SL, Perls TP, Sebastiani P. Metabolomic signatures of extreme old age: findings from the New England Centenarian Study. Geroscience. 2026 Mar 27. PMID: 41888502.
Published on 3/11/2026Kroehling L, Chen A, Spinella A, Reed E, Kukuruzinska M, Varelas X, Monti S. A highly resolved integrated single-cell atlas of HPV-negative head and neck cancer. Commun Med (Lond). 2026 Mar 11; 6(1). PMID: 41813916.
Published on 2/21/2026Li M, Song Z, Reed E, Karagiannis TT, Andersen S, Brent M, Mateusiak C, Acharya S, Jung WJ, Liao S, Wojczynski MK, Feitosa MF, O'Connell JR, Montasser ME, Thorpe RJ, Arbeev K, Milman S, Tai A, Perls TT, Sebastiani P, Monti S. Whole blood transcriptional signatures of age and survival identified in long life family and integrative longevity omics studies. Geroscience. 2026 Feb 21. PMID: 41723297.
Published on 2/4/2026Chen A, Kroehling L, Ennis CS, Denis GV, Monti S. A highly resolved integrated single-cell atlas of human breast cancers. NAR Genom Bioinform. 2026 Mar; 8(1):lqaf217. PMID: 41640877.
Published on 1/16/2026Chakraborty AK, Kroehling L, Raut RD, Choudhury C, Kukuruzinska MA, Gutkind JS, Varelas X, Sahay B, Monti S, Bais MV. LSD1 Inhibition Induces MHC-I and Dendritic Cell Activation to Promote Antitumor Immunity in Head and Neck Squamous Cell Carcinoma. Cancer Res. 2026 Jan 16; 86(2):503-518. PMID: 41066547.
Published on 11/29/2025Sebastiani P, Reed E, Chandler KB, Lopez P, Lords H, Bae H, Costello CE, Au M, Deng LL, Li M, Xiang Q, Noh H, Pflieger L, Funk C, Rappaport N, Nygaard M, Short MI, Brent M, Monti S, Andersen SL, Perls TT. A Robust Serum Proteomic Signature of the E2 Allele of Apolipoprotein E. Adv Sci (Weinh). 2026 Jan; 13(4):e09764. PMID: 41316897.
Published on 10/11/2025Dowrey TW, Cranston SF, Skvir NJ, Lok Y, Bock P, Kharitonova EK, MacDonald E, Zeldich E, Gabel CV, Tyshkovskiy A, Monti S, Gladyshev VN, Sebastiani P, Perls TT, Andersen S, Murphy GJ. IPSC-based modeling of resiliency in centenarians reveals longevity-specific signatures. bioRxiv. 2025 Oct 11. PMID: 41279005.
Published on 9/16/2025Monti S, Lustgarten MS, Huang Z, Song Z, Ellis D, Tian Q, Ferrucci L, Rappaport N, Andersen SL, Perls TP, Sebastiani P. METABOLOMIC SIGNATURES OF EXTREME OLD AGE: FINDINGS FROM THE NEW ENGLAND CENTENARIAN STUDY. bioRxiv. 2025 Sep 16. PMID: 41000658.
Published on 8/26/2025Ennis CS, Seen M, Chen A, Kang H, Ilinski A, Mahdaviani K, Ko NY, Monti S, Denis GV. Plasma exosomes from individuals with type 2 diabetes drive breast cancer aggression in patient-derived organoids. Commun Biol. 2025 Aug 26; 8(1):1276. PMID: 40858992.
Published on 7/18/2025Li M, Song Z, Reed E, Karagiannis TT, Andersen S, Brent M, Mateusiak C, Acharya S, Jung WS, Liao S, Wojczynski MK, Feitosa MF, O'Connell JR, Montasser ME, Thorpe RJ, Arbeev K, Milman S, Tai A, Perls TT, Sebastiani P, Monti S. Whole blood transcriptional signatures of age and survival identified in Long Life Family and Integrative Longevity Omics Studies. bioRxiv. 2025 Jul 18. PMID: 40791342.
Media Mentions
Published on 10/6/2024
Making breakthroughs in fight against breast cancer
Published on 4/18/2023
Study: Strong immune cells may be the key to living to 100
Published on 4/6/2023
Immune System May Hold Secret to Living to 100
Published on 4/5/2023
New Study Finds The Key To Living To 100 And Beyond
Published on 4/5/2023
Secret To Longevity? Scientists Find Unique Immune Cells In Centenarians That Protect From Illnesses
Published on 4/5/2023
‘Elite’ Immune Systems Could Be Centenarians’ Secret: Study
Published on 4/4/2023
DNA study reveals one key factor that helps some people live beyond 100
Published on 4/4/2023
This is what you need to live to 100: DNA study
Published on 4/3/2023
A 'blueprint' for longevity: New study has an answer for why some people live to be over 100
Published on 8/10/2021
Chemicals in Your Furniture Might Impact Your Metabolism
View full list of 12 media mentions.