Stefano Monti PhD

Professor, Computational Biomedicine

Associate Professor, Biostatistics

75 E. Newton St | (617) 414-7031
smonti@bu.edu

Sections

Computational Biomedicine

Centers

BU-BMC Cancer Center

Evans Center for Interdisciplinary Biomedical Research

Biography

Stefano Monti is a Computational Biologist and joined the BU faculty in January 2011 in the section of Computational Biomedicine, with joint appointments in the Biostatistics Department and the Bioinformatics program. Monti received his Ph.D. in Intelligent Systems and Artificial Intelligence from the University of Pittsburgh, and completed his training with a post-doctoral fellowship at the Robotics Institute at Carnegie Mellon. His doctoral and post-doctoral research focused on the development of machine learning and knowledge discovery methodologies, with a particular emphasis on probabilistic reasoning and Bayesian approaches to modeling biomedical data. Since 2001, he has worked in the field of Cancer Genomics, first as a Research Scientist at the Whitehead Institute’s Center for Genome Research, and later as a Computational Biologist in the Cancer Program at the Broad Institute.

Dr. Monti's laboratory integrates systems biology, machine learning, and bioinformatics approaches to investigate the molecular drivers of human disease, with the goals of advancing prevention and care. This multidisciplinary effort relies on the development of novel computational methodologies, and on the design of experiments based on the generation and integrative analysis of high-throughput multi-omics data, with the goal of identifying novel therapeutic targets and developing accurate diagnostic and prognostic biomarkers. Specific areas of research include the study of the molecular mechanisms of tumor initiation and progression and of the role played in it by environmental exposure, as well as the study of the biological factors contributing to healthy aging and extreme longevity.

Other Positions

Websites

BU Profile

Department of Medicine Faculty

Twitter

Researchgate

Education

Artificial Intelligence, PhD, University of Pittsburgh

Artificial Intelligence, MS, University of Pittsburgh

Computer Science, MS, University of Houston

Computer Science, BS, Università degli Studi di Udine

Publications

Published on 5/3/2025

Chen AD, Kroehling L, Ennis C, Denis GV, Monti S. A highly resolved integrated transcriptomic atlas of human breast cancers. bioRxiv. 2025 May 03. PMID: 40161579.

PubMed

Published on 4/7/2025

Rogina B, Anderson R, LeBrasseur NK, Curran SP, Yousefzadeh MJ, Ghosh B, Duque G, Howlett S, Austad S, Demuth I, Gerstorf D, Korfhage J, Lombard DB, Abadir P, Christensen K, Carey JR, Alberts SC, Campos F, Palavicini JP, Palmer A, Bell J, Basisty N, de Cabo R, Gomes A, Dixit VD, Sen P, Baur JA, Imai SI, Li X, Valdez G, Orr ME, Pletcher S, Andersen J, Jones L, Castillo-Azofeida D, Bonaguidi M, Suh Y, Duncan FE, Murray A, Wang MC, Burkewitz K, Henne M, Zhou K, Bouhrara M, Benjamini D, Kolind S, Walker KA, Reiter DA, Dean DC, Gorbunova V, Gladyshev VN, Palovics R, Niedernhofer LJ, Fan R, Bueckle AD, Hurley J, Esser KA, Kapahi P, Sato S, Jiang N, Ashiqueali SA, Diaz J, Mishra SP, Raimundo N, Banarjee R, Allsopp R, Reynolds LM, Zhang B, Sebastiani P, Monti S, Schork N, Rappaport N. Symposia Report of The Annual Biological Sciences Section Meeting of the Gerontological Society of America 2023, Tampa, Florida. J Gerontol A Biol Sci Med Sci. 2025 Apr 07; 80(5). PMID: 39932386.

PubMed

Published on 3/17/2025

Chakraborty AK, Kroehling L, Raut RD, Choudhury C, Kukuruzinska M, Gutkind JS, Varelas X, Sahay B, Monti S, Bais MV. LSD1 inhibition corrects dysregulated MHC-I and dendritic cells activation through IFN?-CXCL9-CXCR3 axis to promote antitumor immunity in HNSCC. bioRxiv. 2025 Mar 17. PMID: 40166238.

PubMed

Published on 3/6/2025

Qiu Y, Chen A, Yu R, Llevenes P, Seen M, Ko NY, Monti S, Denis GV. Insulin Resistance Increases TNBC Aggressiveness and Brain Metastasis via Adipocyte-derived Exosomes. Mol Cancer Res. 2025 Mar 06. PMID: 40047645.

PubMed

Published on 3/4/2025

Kroehling L, Chen A, Spinella A, Reed E, Kukuruzinka M, Varelas X, Monti S. A highly resolved integrated single-cell atlas of HPV-negative head and neck cancer. bioRxiv. 2025 Mar 04. PMID: 40093171.

PubMed

Published on 3/3/2025

Snyder M, Wang Z, Lara B, Fimbres J, Pichardo T, Mazzilli S, Khan MM, Duggineni VK, Monti S, Sherr DH. The aryl hydrocarbon receptor controls IFN-?-induced immune checkpoints PD-L1 and IDO via the JAK/STAT pathway in lung adenocarcinoma. J Immunol. 2025 Mar 03. PMID: 40073102.

PubMed

Published on 2/14/2025

Kern JG, Kroehling L, Spinella AJ, Monti S, Varelas X. LATS1/2 inactivation in the mammary epithelium drives the evolution of a tumor-associated niche. EMBO Rep. 2025 Mar; 26(6):1472-1503. PMID: 39953252.

PubMed

Published on 11/5/2024

Sebastiani P, Monti S, Lustgarten MS, Song Z, Ellis D, Tian Q, Schwaiger-Haber M, Stancliffe E, Leshchyk A, Short MI, Ardisson Korat AV, Gurinovich A, Karagiannis T, Li M, Lords HJ, Xiang Q, Marron MM, Bae H, Feitosa MF, Wojczynski MK, O'Connell JR, Montasser ME, Schupf N, Arbeev K, Yashin A, Schork N, Christensen K, Andersen SL, Ferrucci L, Rappaport N, Perls TT, Patti GJ. Metabolite signatures of chronological age, aging, survival, and longevity. Cell Rep. 2024 Nov 26; 43(11):114913. PMID: 39504246.

PubMed

Published on 10/12/2024

Llevenes P, Chen A, Lawton M, Qiu Y, Seen M, Monti S, Denis GV. Plasma Exosomes in Insulin Resistant Obesity Exacerbate Progression of Triple Negative Breast Cancer. bioRxiv. 2024 Oct 12. PMID: 39416125.

PubMed

Published on 9/19/2024

Ennis CS, Seen M, Chen A, Kang H, Ilinski A, Mahdaviani K, Ko N, Monti S, Denis GV. Plasma exosomes from individuals with type 2 diabetes drive breast cancer aggression in patient-derived organoids. bioRxiv. 2024 Sep 19. PMID: 39345362.

PubMed

View full list of 152 publications.