S. Reza Jafarzadeh DVM, MPVM, PhD

Assistant Professor, Rheumatology

650 Albany St | (617) 358-9665
S. Reza Jafarzadeh



Arthritis & Autoimmune Diseases Research Center


I am interested in the application of causal inference methods in observational studies, especially in the setting of longitudinal data, where time-varying exposures, time-dependent confounding, and selection bias are often present. In particular, I am interested in the application of the variety of modern analytical techniques for estimating causal effects as well as the concepts such as direct and indirect effect decomposition (causal mediation analysis), causal interactions and sufficient causes, and causal interference and spill-over effects. These analytical techniques can be applied to broad areas of health sciences research, but I am particularly interested in the application of causal inference for comparative effectiveness research and implementation science. The methods are very useful for the development and assessment of strategies to improve population health using non-experimental data.

I am also interested in the application of Bayesian methods for evaluation of diagnostic tests and prevalence estimation in the absence of a perfect reference standard. These methods have broad applications in diagnosis and screening, and can be used to estimate true prevalence using imperfect tests.


DVM, University of Tehran

MPVM, University of California, Davis

PhD, University of California, Davis


Published on 5/1/2023

Bosch NA, Teja B, Law AC, Pang B, Jafarzadeh SR, Walkey AJ. Comparative Effectiveness of Fludrocortisone and Hydrocortisone vs Hydrocortisone Alone Among Patients With Septic Shock. JAMA Intern Med. 2023 May 01; 183(5):451-459. PMID: 36972033.

Published on 3/31/2023

Corrigan P, Neogi T, Frey-Law L, Jafarzadeh SR, Segal N, Nevitt MC, Lewis CE, Stefanik JJ. Relation of pain sensitization to self-reported and performance-based measures of physical functioning: the Multicenter Osteoarthritis (MOST) study. Osteoarthritis Cartilage. 2023 Mar 31. PMID: 37003421.

Published on 3/3/2023

Costello KE, Felson DT, Jafarzadeh SR, Guermazi A, Roemer FW, Segal NA, Lewis CE, Nevitt MC, Lewis CL, Kolachalama VB, Kumar D. Gait, physical activity and tibiofemoral cartilage damage: a longitudinal machine learning analysis in the Multicenter Osteoarthritis Study. Br J Sports Med. 2023 Mar 03. PMID: 36868795.

Published on 12/23/2022

Bacon KL, Felson DT, Jafarzadeh SR, Kolachalama VB, Hausdorff JM, Gazit E, Segal NA, Lewis CE, Nevitt MC, Kumar D. Relation of gait measures with mild unilateral knee pain during walking using machine learning. Sci Rep. 2022 Dec 23; 12(1):22200. PMID: 36564397.

Published on 10/15/2022

Riddle DL, Reza Jafarzadeh S. Effects of psychological distress on the general health to self-reported pain and function outcome relationship in knee arthroplasty: A causal mediation study. Osteoarthr Cartil Open. 2022 Dec; 4(4):100315. PMID: 36474788.

Published on 9/28/2022

Rose MJ, LaValley MP, Jafarzadeh SR, Costello KE, Shah N, Lee S, Borrelli B, Messier SP, Neogi T, Kumar D. Impact of COVID-19 Pandemic on Physical Activity, Pain, Mood, and Sleep in Adults with Knee Osteoarthritis. J Meas Phys Behav. 2022 Dec; 5(4):294-298. PMID: 36779003.

Published on 9/2/2022

Jafarzadeh SR, Neogi T. Causal inference from observational data and target trial emulation. Osteoarthritis Cartilage. 2022 Nov; 30(11):1415-1417. PMID: 36063988.

Published on 9/1/2022

Jafarzadeh SR, Neogi T, White DK, Felson DT. The Relationship of Pain Reduction With Prevention of Knee Replacement Under Dynamic Intervention Strategies. Arthritis Rheumatol. 2022 Oct; 74(10):1668-1675. PMID: 35726122.

Published on 6/28/2022

Gl√łersen M, Neogi T, Jafarzadeh SR, Sexton J, Haugen IK. Reply. Arthritis Rheumatol. 2022 Aug; 74(8):1454-1455. PMID: 35358373.

Published on 6/11/2022

Carlesso LC, Jafarzadeh SR, Stokes A, Felson DT, Wang N, Frey-Law L, Lewis CE, Nevitt M, Neogi T. Depressive symptoms and multi-joint pain partially mediate the relationship between obesity and opioid use in people with knee osteoarthritis. Osteoarthritis Cartilage. 2022 Sep; 30(9):1263-1269. PMID: 35700904.

View full list of 53 publications.