Paul Maglione MD, PhD

Assistant Professor, Pulmonary, Allergy, Sleep & Critical Care Medicine

Graduate Faculty (Primary Mentor of Grad Students)

72 E. Concord Street | (617) 358-0913
Paul Maglione

Pulmonary, Allergy, Sleep & Critical Care Medicine


Pulmonary Center


Paul J. (PJ) Maglione, MD, PhD is an Assistant Professor of Medicine in the Section of Pulmonary, Allergy, Sleep & Critical Care Medicine at the Chobanian and Avedisian School of Medicine. He is a physician-scientist with expertise in the clinical care of primary immunodeficiencies and runs a laboratory in the Pulmonary Center at the Boston University Medical Campus. Before arriving at the university, Dr. Maglione was an attending physician and researcher at the Icahn School of Medicine at Mount Sinai. He completed his MD/PhD training at the Albert Einstein College of Medicine and internal medicine residency at Mount Sinai Hospital in New York. Also at Mount Sinai, Dr. Maglione undertook fellowship training in clinical immunology and post-doctoral research under the mentorship of Charlotte Cunningham-Rundles, MD, PhD, a renowned expert in common variable immunodeficiency.

Clinical Focus:
Dr. Maglione is an attending physician at Boston Medical Center where he focuses on the diagnosis and treatment of primary immunodeficiency disorders, with special expertise in the care of common variable immunodeficiency and its complications. He also attends on the inpatient allergy/immunology service. Dr. Maglione is involved in the teaching of allergy/immunology clinical fellows in the Chobanian and Avedisian School of Medicine program. He has been invited to speak to patient audiences on numerous occasions by the Immune Deficiency Foundation, including their national conference, and cares for patients with immune deficiency disorders from around the country.

Research Focus:
Dr. Maglione studies human B cell biology through the lens of primary immunodeficiency. Dr. Maglione's clinical focus on antibody deficiency syndromes dovetails with his research focus on mechanisms of B cell dysfunction in humans. For numerous years, he has been investigating mechanisms underlying non-infectious complications of the most prevalent form of symptomatic primary antibody deficiency, common variable immunodeficiency (CVID). Recent work has focused upon the pathogenesis of interstitial lung disease affecting CVID patients, particularly upon the biology of B cell dysfunction in this disease. Dr. Maglione has helped devise therapeutic strategies to treat gastrointestinal and pulmonary complications of common variable immunodeficiency. His research utilizes high throughput strategies that include seromics, antibody arrays, genomics, and RNA sequencing coupled with cell culture, biopsies, and information from the medical record to define how B cell defects shape human disease.


Microbiology, BS, University of Rochester

Immunology, MD/PhD, Albert Einstein College of Medicine


Published on 10/12/2023

Sullivan NP, Maniam N, Maglione PJ. Interstitial lung diseases in inborn errors of immunity. Curr Opin Allergy Clin Immunol. 2023 Dec 01; 23(6):500-506. PMID: 37823528.

Published on 10/5/2023

Ong MS, Rider NL, Stein S, Maglione PJ, Galbraith A, DiGiacomo DV, Farmer JR. Racial and ethnic disparities in early mortality among patients with inborn errors of immunity. J Allergy Clin Immunol. 2024 Jan; 153(1):335-340.e1. PMID: 37802474.

Published on 5/8/2023

Bintalib HM, van de Ven A, Jacob J, Davidsen JR, Fevang B, Hanitsch LG, Malphettes M, van Montfrans J, Maglione PJ, Milito C, Routes J, Warnatz K, Hurst JR. Diagnostic testing for interstitial lung disease in common variable immunodeficiency: a systematic review. Front Immunol. 2023; 14:1190235. PMID: 37223103.

Published on 3/8/2023

Chen Y, Bharrhan S, Xu J, Sharma T, Wang Y, Salgame P, Zhang J, Nargan K, Steyn AJC, Maglione PJ, Chan J. B cells promote granulomatous inflammation during chronic Mycobacterium tuberculosis infection in mice. PLoS Pathog. 2023 Mar; 19(3):e1011187. PMID: 36888692.

Published on 10/14/2022

Gutierrez MJ, Nino G, Sun D, Restrepo-Gualteros S, Sadreameli SC, Fiorino EK, Wu E, Vece T, Hagood JS, Maglione PJ, Kurland G, Koumbourlis A, Sullivan KE. The lung in inborn errors of immunity: From clinical disease patterns to molecular pathogenesis. J Allergy Clin Immunol. 2022 Dec; 150(6):1314-1324. PMID: 36244852.

Published on 9/27/2022

Ye X, Maglione PJ, Wehr C, Li X, Wang Y, Abolhassani H, Deripapa E, Liu D, Borte S, Du L, Wan H, Plötner A, Giannoula Y, Ko HB, Hou Y, Zhu S, Grossman JK, Sander B, Grimbacher B, Hammarström L, Fedorova A, Rosenzweig SD, Shcherbina A, Wu K, Warnatz K, Cunningham-Rundles C, Pan-Hammarström Q. Genomic characterization of lymphomas in patients with inborn errors of immunity. Blood Adv. 2022 Sep 27; 6(18):5403-5414. PMID: 35687490.

Published on 8/15/2022

Ameratunga R, Abolhassani H, Maglione PJ, Edwards ESJ. Editorial: Contemporary challenges in diagnosis and treatment of predominantly antibody deficiency. Front Immunol. 2022; 13:959720. PMID: 36052063.

Published on 10/1/2021

Maglione PJ, Gereige JD, Lee TK. Consideration of pulmonary hypertension in the evaluation of common variable immunodeficiency. Ann Allergy Asthma Immunol. 2021 10; 127(4):513. PMID: 34593104.

Published on 6/17/2021

Abyazi ML, Bell KA, Gyimesi G, Baker TS, Byun M, Ko HM, Cunningham-Rundles C, Feng F, Maglione PJ. Convergence of cytokine dysregulation and antibody deficiency in common variable immunodeficiency with inflammatory complications. J Allergy Clin Immunol. 2022 01; 149(1):315-326.e9. PMID: 34146579.

Published on 3/23/2021

Wallace LJ, Ware MS, Cunningham-Rundles C, Fuleihan RL, Maglione PJ. Clinical disparity of primary antibody deficiency patients at a safety net hospital. J Allergy Clin Immunol Pract. 2021 07; 9(7):2923-2925.e1. PMID: 33766581.

View full list of 42 publications.