Paul Maglione MD, PhD

Assistant Professor, Pulmonary, Allergy, Sleep & Critical Care Medicine

Graduate Faculty (Primary Mentor of Grad Students)

72 E. Concord Street | (617) 358-0913
Paul Maglione
Sections

Pulmonary, Allergy, Sleep & Critical Care Medicine

Centers

Pulmonary Center

Biography

Background:
Paul J. (PJ) Maglione, MD, PhD is an Assistant Professor of Medicine in the Section of Pulmonary, Allergy, Sleep & Critical Care Medicine at the Boston University School of Medicine. He is a physician-scientist with expertise in the clinical care of primary immunodeficiencies and runs a laboratory in the Pulmonary Center at the Boston University Medical Campus. Before arriving at the university, Dr. Maglione was an attending physician and researcher at the Icahn School of Medicine at Mount Sinai. He completed his MD/PhD training at the Albert Einstein College of Medicine and internal medicine residency at Mount Sinai Hospital in New York. Also at Mount Sinai, Dr. Maglione undertook fellowship training in clinical immunology and post-doctoral research under the mentorship of Charlotte Cunningham-Rundles, MD, PhD, a renowned expert in common variable immunodeficiency.

Clinical Focus:
Dr. Maglione is an attending physician at Boston Medical Center where he focuses on the diagnosis and treatment of primary immunodeficiency disorders, with special expertise in the care of common variable immunodeficiency and its complications. He also attends on the inpatient allergy/immunology service. Dr. Maglione is involved in the teaching of allergy/immunology clinical fellows in the Boston University School of Medicine program. He has been invited to speak to patient audiences on numerous occasions by the Immune Deficiency Foundation, including their national conference, and cares for patients with immune deficiency disorders from around the country.

Research Focus:
Dr. Maglione studies human B cell biology through the lens of primary immunodeficiency. Dr. Maglione's clinical focus on antibody deficiency syndromes dovetails with his research focus on mechanisms of B cell dysfunction in humans. For numerous years, he has been investigating mechanisms underlying non-infectious complications of the most prevalent form of symptomatic primary antibody deficiency, common variable immunodeficiency (CVID). Recent work has focused upon the pathogenesis of interstitial lung disease affecting CVID patients, particularly upon the biology of B cell dysfunction in this disease. Dr. Maglione has helped devise therapeutic strategies to treat gastrointestinal and pulmonary complications of common variable immunodeficiency. His research utilizes high throughput strategies that include seromics, antibody arrays, genomics, and RNA sequencing coupled with cell culture, biopsies, and information from the medical record to define how B cell defects shape human disease.

Education

Microbiology, BS, University of Rochester, 2002

Immunology, MD/PhD, Albert Einstein College of Medicine, 2009

Publications

Published on 10/1/2021

Maglione PJ, Gereige JD, Lee TK. Consideration of pulmonary hypertension in the evaluation of common variable immunodeficiency. Ann Allergy Asthma Immunol. 2021 10; 127(4):513. PMID: 34593104.

Published on 6/17/2021

Abyazi ML, Bell KA, Gyimesi G, Baker TS, Byun M, Ko HM, Cunningham-Rundles C, Feng F, Maglione PJ. Convergence of cytokine dysregulation and antibody deficiency in common variable immunodeficiency with inflammatory complications. J Allergy Clin Immunol. 2021 Jun 17. PMID: 34146579.

Published on 3/23/2021

Wallace LJ, Ware MS, Cunningham-Rundles C, Fuleihan RL, Maglione PJ. Clinical disparity of primary antibody deficiency patients at a safety net hospital. J Allergy Clin Immunol Pract. 2021 07; 9(7):2923-2925.e1. PMID: 33766581.

Published on 3/11/2021

Lee TK, Gereige JD, Maglione PJ. State-of-the-art diagnostic evaluation of common variable immunodeficiency. Ann Allergy Asthma Immunol. 2021 07; 127(1):19-27. PMID: 33716149.

Published on 2/5/2021

Matson EM, Abyazi ML, Bell KA, Hayes KM, Maglione PJ. B Cell Dysregulation in Common Variable Immunodeficiency Interstitial Lung Disease. Front Immunol. 2020; 11:622114. PMID: 33613556.

Published on 10/6/2020

Cowan J, Bonagura VR, Lugar PL, Maglione PJ, Patel NC, Vinh DC, Hofmann JH, Praus M, Rojavin MA. Safety and Tolerability of Manual Push Administration of Subcutaneous IgPro20 at High Infusion Rates in Patients with Primary Immunodeficiency: Findings from the Manual Push Administration Cohort of the HILO Study. J Clin Immunol. 2021 01; 41(1):66-75. PMID: 33025378.

Published on 7/31/2020

Grasset EK, Chorny A, Casas-Recasens S, Gutzeit C, Bongers G, Thomsen I, Chen L, He Z, Matthews DB, Oropallo MA, Veeramreddy P, Uzzan M, Mortha A, Carrillo J, Reis BS, Ramanujam M, Sintes J, Magri G, Maglione PJ, Cunningham-Rundles C, Bram RJ, Faith J, Mehandru S, Pabst O, Cerutti A. Gut T cell-independent IgA responses to commensal bacteria require engagement of the TACI receptor on B cells. Sci Immunol. 2020 07 31; 5(49). PMID: 32737068.

Published on 6/9/2020

Maglione PJ. Chronic Lung Disease in Primary Antibody Deficiency: Diagnosis and Management. Immunol Allergy Clin North Am. 2020 08; 40(3):437-459. PMID: 32654691.

Published on 12/12/2019

Gereige JD, Maglione PJ, Guenechea-Sola M. Delayed Diagnosis of Good Syndrome. J Allergy Clin Immunol Pract. 2020 04; 8(4):1396-1397. PMID: 31839563.

Published on 12/10/2019

Gereige JD, Maglione PJ. Current Understanding and Recent Developments in Common Variable Immunodeficiency Associated Autoimmunity. Front Immunol. 2019; 10:2753. PMID: 31921101.

View full list of 35 publications.