Michael J. Herriges PhD
Assistant Professor, Pulmonary, Allergy, Sleep & Critical Care Medicine
670 Albany St | (617) 358-0376herriges@bu.edu
Sections
Pulmonary, Allergy, Sleep & Critical Care Medicine
Biography
Michael Herriges is an Assistant Professor of Medicine at the Chobanian and Avedisian School of Medicine. He obtained his PhD at the University of Pennsylvania. During this time he worked in the lab of Dr. Ed Morrisey studying the role of lncRNAs in pulmonary development and homeostasis. After completing his thesis, Michael did a postdoctoral fellowship in Dr. Darrell Kotton’s lab at Boston University. During this fellowship he developed a system for the differentiation of embryonic stem cells (ESCs) into lung epithelial progenitors known as tip cells. He then engrafted these ESC-derived cells into injured mouse lungs, where they gave rise to engineered cells that were transcriptionally and functionally similar to endogenous alveolar epithelial cells. Having established his own lab in January 2025, Michael now aims to improve cell engraftment techniques and use these methods to study cell-cell interactions and develop cell therapies for pulmonary diseases like pulmonary fibrosis and bronchopulmonary dysplasia.
Publications
Ma L, Thapa BR, Le Suer JA, Tilston-Lünel A, Herriges MJ, Wang F, Bawa PS, Varelas X, Hawkins FJ, Kotton DN. Author Correction: Life-long functional regeneration of in vivo airway epithelium by the engraftment of airway basal stem cells. Nat Protoc. 2025 Mar 31. PMID: 40164751.
Published on 11/13/2024Kohn A, Herriges MJ, Basak P, Ma L, Thapa BR, Kotton DN, Hawkins FJ. Targeted pre-conditioning and cell transplantation in the murine lower respiratory tract. bioRxiv. 2024 Nov 13. PMID: 39605510.
Published on 11/5/2024Ma L, Thapa BR, Le Suer JA, Tilston-Lünel A, Herriges MJ, Wang F, Bawa PS, Varelas X, Hawkins FJ, Kotton DN. Life-long functional regeneration of in vivo airway epithelium by the engraftment of airway basal stem cells. Nat Protoc. 2025 Mar; 20(3):810-842. PMID: 39501108.
Published on 11/1/2023Yampolskaya M, Herriges MJ, Ikonomou L, Kotton DN, Mehta P. scTOP: physics-inspired order parameters for cellular identification and visualization. Development. 2023 Nov 01; 150(21). PMID: 37756586.
Published on 8/24/2023Ma L, Thapa BR, Le Suer JA, Tilston-Lünel A, Herriges MJ, Berical A, Beermann ML, Wang F, Bawa PS, Kohn A, Ysasi AB, Kiyokawa H, Matte TM, Randell SH, Varelas X, Hawkins FJ, Kotton DN. Airway stem cell reconstitution by the transplantation of primary or pluripotent stem cell-derived basal cells. Cell Stem Cell. 2023 Sep 07; 30(9):1199-1216.e7. PMID: 37625411.
Published on 8/24/2023Herriges MJ, Yampolskaya M, Thapa BR, Lindstrom-Vautrin J, Wang F, Huang J, Na CL, Ma L, Montminy MM, Bawa P, Villacorta-Martin C, Mehta P, Kotton DN. Durable alveolar engraftment of PSC-derived lung epithelial cells into immunocompetent mice. Cell Stem Cell. 2023 Sep 07; 30(9):1217-1234.e7. PMID: 37625412.
Published on 1/25/2023Yampolskaya M, Herriges M, Ikonomou L, Kotton D, Mehta P. scTOP: physics-inspired order parameters for cellular identification and visualization. bioRxiv. 2023 Jan 25. PMID: 36747864.
Published on 2/21/2022Wang SW, Herriges MJ, Hurley K, Kotton DN, Klein AM. CoSpar identifies early cell fate biases from single-cell transcriptomic and lineage information. Nat Biotechnol. 2022 Jul; 40(7):1066-1074. PMID: 35190690.
Published on 10/13/2021Rankin SA, Steimle JD, Yang XH, Rydeen AB, Agarwal K, Chaturvedi P, Ikegami K, Herriges MJ, Moskowitz IP, Zorn AM. Tbx5 drives Aldh1a2 expression to regulate a RA-Hedgehog-Wnt gene regulatory network coordinating cardiopulmonary development. Elife. 2021 10 13; 10. PMID: 34643182.
Published on 10/19/2020Alysandratos KD, Herriges MJ, Kotton DN. Epithelial Stem and Progenitor Cells in Lung Repair and Regeneration. Annu Rev Physiol. 2021 02 10; 83:529-550. PMID: 33074772.