Matthew G. Nayor MD, MPH

Associate Professor, Cardiovascular Medicine

Assistant Professor, Preventive Medicine & Epidemiology

75 E. Newton St | (617) 638-8771
Matthew Nayor
Sections

Cardiovascular Medicine

Preventive Medicine & Epidemiology

Biography

Dr. Nayor is a clinical-translational investigator and heart failure cardiologist. He received training in Internal Medicine at the Johns Hopkins Hospital Osler Medical Residency training program and Cardiology and Heart Failure and Transplantation training at Brigham and Women's Hospital. His research background includes basic science investigations, physiologic studies, and cardiovascular epidemiology focusing on the intersection of metabolic health and cardiovascular disease. His group and collaborators have studied: 1) the effect of exercise on metabolism via assaying >500 circulating metabolites; 2) physiologic determinants of fitness; 3) novel protein biomarkers of heart failure risk through broad proteomic profiling; 4) and lifestyle contributors to cardiometabolic disease and heart failure, among other topics.

Dr. Nayor has worked closely with the Framingham Heart Study for the last 8 years and currently leads community-based studies evaluating metabolic responses to discrete physiologic perturbations, such as exercise and a dietary intervention.

Education

MD, New York University School of Medicine

MPH, Harvard School of Public Health

History, BA, University of Michigan at Ann Arbor

Publications

Published on 1/1/2025

Florea VV, Gajjar P, Huang S, Tang J, Zhao S, Davenport M, Mi MY, Haff M, Zhang X, Miller PE, Vasan RS, Liu CT, Lewis GD, Shah RV, Long MT, Nayor M. Hepatic Steatosis and Fibrosis, Cardiorespiratory Fitness, and Metabolic Mediators in the Community. Liver Int. 2025 Jan; 45(1):e16147. PMID: 39673712.

Published on 12/9/2024

Perry AS, Hadad N, Chatterjee E, Jimenez-Ramos M, Farber-Eger E, Roshani R, Stolze LK, Betti MJ, Zhao S, Huang S, Martens L, Kendall TJ, Thone T, Amancherla K, Bailin S, Gabriel CL, Koethe J, Carr JJ, Terry JG, Vaitinadin NS, Freedman JE, Tanriverdi K, Alsop E, Van Keuren-Jensen K, Sauld JFK, Mahajan G, Khan SS, Colangelo L, Nayor M, Fisher-Hoch S, McCormick JB, North KE, Below JE, Wells QS, Abel ED, Kalhan R, Scott C, Guilliams M, Gamazon ER, Fallowfield JA, Banovich NE, Das S, Shah R. A prognostic molecular signature of hepatic steatosis is spatially heterogeneous and dynamic in human liver. Cell Rep Med. 2024 Dec 17; 5(12):101871. PMID: 39657669.

Published on 11/22/2024

Perry AS, Piaggi P, Huang S, Nayor M, Freedman J, North KE, Below JE, Clish CB, Murthy VL, Krakoff J, Shah RV. Human metabolic chambers reveal a coordinated metabolic-physiologic response to nutrition. JCI Insight. 2024 Nov 22; 9(22). PMID: 39576013.

Published on 11/15/2024

Wang MC, Awoyemi T, Allen NB, Shah R, Nayor M, Luo Y, Lima JAC, Lloyd-Jones DM, Khan SS. Latent class analysis of cardiac structure and function and association with premature cardiovascular disease: The Coronary Artery Risk Development in Young Adults (CARDIA) study. Am J Prev Cardiol. 2024 Dec; 20:100889. PMID: 39655179.

Published on 10/16/2024

McCormick N, Joshi AD, Yokose C, Yu B, Tin A, Terkeltaub R, Merriman TR, Zeleznik O, Eliassen AH, Curhan GC, Ea HK, Nayor M, Raffield LM, Choi HK. Prediagnostic Amino Acid Metabolites and Risk of Gout, Accounting for Serum Urate: Prospective Cohort Study and Mendelian Randomization. Arthritis Care Res (Hoboken). 2024 Dec; 76(12):1666-1674. PMID: 39169570.

Published on 10/14/2024

Lim K, Nayor M, Arroyo E, Burney HN, Li X, Li Y, Shah R, Campain J, Wan D, Ting S, Hiemstra TF, Thadhani R, Moe S, Zehnder D, Larson MG, Vasan RS, Lewis GD. Impairment of Cardiovascular Functional Capacity in Mild-to-Moderate Kidney Dysfunction. Clin J Am Soc Nephrol. 2024 Dec 01; 19(12):1547-1561. PMID: 39401313.

Published on 9/2/2024

Perry AS, Amancherla K, Huang X, Lance ML, Farber-Eger E, Gajjar P, Amrute J, Stolze L, Zhao S, Sheng Q, Joynes CM, Peng Z, Tanaka T, Drakos SG, Lavine KJ, Selzman C, Visker JR, Shankar TS, Ferrucci L, Das S, Wilcox J, Patel RB, Kalhan R, Shah SJ, Walker KA, Wells Q, Tucker N, Nayor M, Shah RV, Khan SS. Clinical-transcriptional prioritization of the circulating proteome in human heart failure. Cell Rep Med. 2024 Sep 17; 5(9):101704. PMID: 39226894.

Published on 8/8/2024

Eromosele OB, Shapira-Daniels A, Yuan A, Lukan A, Akinrimisi O, Chukwurah M, Nayor M, Benjamin EJ, Lin H. The association of exhaled carbon monoxide with atrial fibrillation and left atrial size in the Framingham Heart Study. Am Heart J Plus. 2024 Sep; 45:100439. PMID: 39234302.

Published on 7/12/2024

Li JP, Slocum C, Sbarbaro J, Schoenike M, Campain J, Prasad C, Nayor MG, Lewis GD, Malhotra R. Percent Predicted Peak Exercise Oxygen Pulse Provides Insights Into Ventricular-Vascular Response and Prognosticates HFpEF. JACC Adv. 2024 Aug; 3(8):101101. PMID: 39105119.

Published on 6/28/2024

Miller PE, Gajjar P, Mitchell GF, Khan SS, Vasan RS, Larson MG, Lewis GD, Shah RV, Nayor M. Clusters of multidimensional exercise response patterns and estimated heart failure risk in the Framingham Heart Study. ESC Heart Fail. 2024 Oct; 11(5):3279-3289. PMID: 38943268.

View full list of 90 publications.