Maria Trojanowska PhD
Professor, Rheumatology
Director , Arthritis & Autoimmune Diseases Research Center
75 E. Newton St | (617) 638-4318trojanme@bu.edu
Sections
Rheumatology
Centers
Arthritis & Autoimmune Diseases Research Center
BU-BMC Cancer Center
Pulmonary Center
Evans Center for Interdisciplinary Biomedical Research
Biography
Dr. Trojanowska’s research is aimed at understanding the molecular and cellular mechanisms that regulate ECM synthesis in healthy tissues and in pathological conditions such as fibrosis and tumorigenesis. The majority of her studies focus on the pathogenesis of scleroderma, an autoimmune disease characterized by vascular abnormalities and a prominent fibrosis of the skin. Her laboratory uses molecular and cellular approaches and various experimental models to elucidate the mechanisms responsible for uncontrolled ECM deposition and vessel degeneration in scleroderma. The second area of investigation is related to activation of tumor stroma. These studies examine the molecular mechanisms that mediate controlled regulation of ECM turnover in healthy connective tissue and are responsible for dysregulation of this process during tumorigenesis. Recent studies together with Dr. Lafyatis are examining the role of ER stress in systemic sclerosis.
Other Positions
Websites
Program in Inflammatory Disorders Faculty
Scleroderma Center of Research Translation
Education
PhD, Polish Academy of Sciences
MSc, University of Warsaw
Publications
Yamashita T, Kaplan U, Chakraborty A, Marden G, Gritli S, Roh D, Bujor A, Trojanowski M, Ligresti G, Browning JL, Trojanowska M. ERG regulates lymphatic vessel specification genes and its deficiency impairs wound healing-associated lymphangiogenesis. Arthritis Rheumatol. 2024 Jul 04. PMID: 38965683.
Published on 6/27/2024Raslan AA, Pham TX, Lee J, Kontodimas K, Tilston-Lunel A, Schmottlach J, Hong J, Dinc T, Bujor AM, Caporarello N, Thiriot A, von Andrian UH, Huang SK, Nicosia RF, Trojanowska M, Varelas X, Ligresti G. Lung injury-induced activated endothelial cell states persist in aging-associated progressive fibrosis. Nat Commun. 2024 Jun 27; 15(1):5449. PMID: 38937456.
Published on 1/24/2024Chakraborty A, Kim A, AlAbdullatif S, Campbell JD, Alekseyev YO, Kaplan U, Dambal V, Ligresti G, Trojanowska M. Endothelial Erg Regulates Expression of Pulmonary Lymphatic Junctional and Inflammation Genes in Mouse Lungs Impacting Lymphatic Transport. Res Sq. 2024 Jan 24. PMID: 38343832.
Published on 4/22/2023Toyama T, Kudryashova TV, Ichihara A, Lenna S, Looney A, Shen Y, Jiang L, Teos L, Avolio T, Lin D, Kaplan U, Marden G, Dambal V, Goncharov D, Delisser H, Lafyatis R, Seta F, Goncharova EA, Trojanowska M. GATA6 coordinates cross-talk between BMP10 and oxidative stress axis in pulmonary arterial hypertension. Sci Rep. 2023 Apr 22; 13(1):6593. PMID: 37087509.
Published on 1/23/2023El-Adili F, Lui JK, Najem M, Farina G, Trojanowska M, Sam F, Bujor AM. Correction: Periostin overexpression in scleroderma cardiac tissue and its utility as a marker for disease complications. Arthritis Res Ther. 2023 Jan 23; 25(1):11. PMID: 36691037.
Published on 1/20/2023Raslan AA, Pham TX, Lee J, Hong J, Schmottlach J, Nicolas K, Dinc T, Bujor AM, Caporarello N, Thiriot A, von Andrian UH, Huang SK, Nicosia RF, Trojanowska M, Varelas X, Ligresti G. Single Cell Transcriptomics of Fibrotic Lungs Unveils Aging-associated Alterations in Endothelial and Epithelial Cell Regeneration. bioRxiv. 2023 Jan 20. PMID: 36712020.
Published on 11/11/2022El-Adili F, Lui JK, Najem M, Farina G, Trojanowska M, Sam F, Bujor AM. Periostin overexpression in scleroderma cardiac tissue and its utility as a marker for disease complications. Arthritis Res Ther. 2022 Nov 11; 24(1):251. PMID: 36369212.
Published on 9/28/2022Caporarello N, Lee J, Pham TX, Jones DL, Guan J, Link PA, Meridew JA, Marden G, Yamashita T, Osborne CA, Bhagwate AV, Huang SK, Nicosia RF, Tschumperlin DJ, Trojanowska M, Ligresti G. Author Correction: Dysfunctional ERG signaling drives pulmonary vascular aging and persistent fibrosis. Nat Commun. 2022 Sep 28; 13(1):5687. PMID: 36171208.
Published on 7/25/2022Caporarello N, Lee J, Pham TX, Jones DL, Guan J, Link PA, Meridew JA, Marden G, Yamashita T, Osborne CA, Bhagwate AV, Huang SK, Nicosia RF, Tschumperlin DJ, Trojanowska M, Ligresti G. Dysfunctional ERG signaling drives pulmonary vascular aging and persistent fibrosis. Nat Commun. 2022 Jul 25; 13(1):4170. PMID: 35879310.
Published on 5/30/2022Huang M, Smith A, Watson M, Bhandari R, Baugh LM, Ivanovska I, Watkins T, Lang I, Trojanowska M, Black LD, Pioli PA, Garlick J, Whitfield ML. Self-Assembled Human Skin Equivalents Model Macrophage Activation of Cutaneous Fibrogenesis in Systemic Sclerosis. Arthritis Rheumatol. 2022 Jul; 74(7):1245-1256. PMID: 35212485.
Media Mentions
Published on 7/25/2022
Researchers identify protein connected to aging and idiopathic pulmonary fibrosis
View full list of 1 media mentions.