Maria Trojanowska PhD

Professor, Rheumatology

Director , Arthritis & Autoimmune Diseases Research Center

75 E. Newton St | (617) 638-4318
Maria Trojanowska
Sections

Rheumatology

Centers

Arthritis & Autoimmune Diseases Research Center

BU-BMC Cancer Center

Pulmonary Center

Evans Center for Interdisciplinary Biomedical Research

Biography

Dr. Trojanowska’s research is aimed at understanding the molecular and cellular mechanisms that regulate ECM synthesis in healthy tissues and in pathological conditions such as fibrosis and tumorigenesis. The majority of her studies focus on the pathogenesis of scleroderma, an autoimmune disease characterized by vascular abnormalities and a prominent fibrosis of the skin. Her laboratory uses molecular and cellular approaches and various experimental models to elucidate the mechanisms responsible for uncontrolled ECM deposition and vessel degeneration in scleroderma. The second area of investigation is related to activation of tumor stroma. These studies examine the molecular mechanisms that mediate controlled regulation of ECM turnover in healthy connective tissue and are responsible for dysregulation of this process during tumorigenesis. Recent studies together with Dr. Lafyatis are examining the role of ER stress in systemic sclerosis.

Other Positions

Education

PhD, Polish Academy of Sciences, 1980

MSc, University of Warsaw, 1973

Publications

Published on 9/21/2021

Ferdous A, Singh S, Luo Y, Abedin MJ, Jiang N, Perry CE, Evers BM, Gillette TG, Kyba M, Trojanowska M, Hill JA. Fli1 Promotes Vascular Morphogenesis by Regulating Endothelial Potential of Multipotent Myogenic Progenitors. Circ Res. 2021 Sep 21. PMID: 34544261.

Published on 5/27/2021

Lenna S, Tan FK, Trojanowska M. Letter of Retraction. J Immunol. 2021 06 01; 206(11):2763. PMID: 34045319.

Published on 5/8/2021

Miura S, Watanabe Y, Saigusa R, Yamashita T, Nakamura K, Hirabayashi M, Miyagawa T, Yoshizaki A, Trojanowska M, Sato S, Asano Y. Fli1 deficiency suppresses RALDH1 activity of dermal dendritic cells and related induction of regulatory T cells: a possible role in scleroderma. Arthritis Res Ther. 2021 05 08; 23(1):137. PMID: 33964960.

Published on 4/19/2021

Farina A, Rosato E, York M, Gewurz BE, Trojanowska M, Farina GA. Innate Immune Modulation Induced by EBV Lytic Infection Promotes Endothelial Cell Inflammation and Vascular Injury in Scleroderma. Front Immunol. 2021; 12:651013. PMID: 33953718.

Published on 10/30/2020

Nakamura K, Taniguchi T, Hirabayashi M, Yamashita T, Saigusa R, Miura S, Takahashi T, Toyama T, Ichimura Y, Yoshizaki A, Trojanowska M, Fujiu K, Nagai R, Sato S, Asano Y. Altered Properties of Endothelial Cells and Mesenchymal Stem Cells Underlying the Development of Scleroderma-like Vasculopathy in KLF5+/- ;Fli-1+/- Mice. Arthritis Rheumatol. 2020 12; 72(12):2136-2146. PMID: 32627966.

Published on 10/9/2020

Mazzotta C, Marden G, Farina A, Bujor A, Trojanowski MA, Trojanowska M. FLI1 and ERG protein degradation is regulated via Cathepsin B lysosomal pathway in human dermal microvascular endothelial cells. Microcirculation. 2021 01; 28(1):e12660. PMID: 32979864.

Published on 7/31/2020

Marden G, Wan Q, Wilks J, Nevin K, Feeney M, Wisniacki N, Trojanowski M, Bujor A, Stawski L, Trojanowska M. The role of the oncostatin M/OSM receptor ß axis in activating dermal microvascular endothelial cells in systemic sclerosis. Arthritis Res Ther. 2020 07 31; 22(1):179. PMID: 32736577.

Published on 5/19/2020

Bujor AM, El Adili F, Parvez A, Marden G, Trojanowska M. Fli1 Downregulation in Scleroderma Myeloid Cells Has Profibrotic and Proinflammatory Effects. Front Immunol. 2020; 11:800. PMID: 32508810.

Published on 4/4/2020

Huang M, Cai G, Baugh LM, Liu Z, Smith A, Watson M, Popovich D, Zhang T, Stawski LS, Trojanowska M, Georgakoudi I, Black LD, Pioli PA, Whitfield ML, Garlick J. Systemic Sclerosis Dermal Fibroblasts Induce Cutaneous Fibrosis Through Lysyl Oxidase-like 4: New Evidence From Three-Dimensional Skin-like Tissues. Arthritis Rheumatol. 2020 05; 72(5):791-801. PMID: 31705627.

Published on 2/1/2020

Stochmal A, Czuwara J, Trojanowska M, Rudnicka L. Antinuclear Antibodies in Systemic Sclerosis: an Update. Clin Rev Allergy Immunol. 2020 Feb; 58(1):40-51. PMID: 30607749.

View full list of 173 publications.