Marc E. Lenburg PhD
Professor, Computational Biomedicine
Professor, Pathology & Laboratory Medicine
75 E. Newton St | (617) 358-7080mlenburg@bu.edu
Sections
Computational Biomedicine
Centers
BU-BMC Cancer Center
Pulmonary Center
Evans Center for Interdisciplinary Biomedical Research
Biography
Expertise in computational approaches to leverage genome-wide datasets (especially genome-wide gene-expression) for clinical and biological insight. Interests include developing and applying these tools for translational research.
Other Positions
Education
PhD, University of California San Francisco
BA, Wesleyan University
Publications
Lee M, Olson A, Pickering RT, Ieong MH, Kivett D, Roche S, Xiao X, Liu G, Asundi A, Lin NH, Lenburg ME. Alterations to the Bronchial Gene-Expression Effects of Tobacco Smoking in People Living With HIV. J Acquir Immune Defic Syndr. 2026 Jun 01; 101(6):671-679. PMID: 41734085.
Published on 5/20/2026Fisher N, Xue L, Smith KK, Tao B, Cunha JA, Ladenheim S, Moreira-Bouchard JD, Milstone ZJ, Zhebrun A, Zhang X, Jun GR, Stein TD, Ang TFA, Farrer LA, Farb MG, Padera RF, Benjamin EJ, Levy D, Gopal DM, Isaac RS, Lenburg ME, Choi SH, Fetterman JL. Mitochondrial genetic variation across tissues of the human body. Nucleic Acids Res. 2026 May 20; 54(10). PMID: 42179041.
Published on 5/6/2026Anderson KE, Tran LM, Krysan K, Kefella Y, Yu L, Fishbein GA, Rodriguez EF, Shabihkhani M, Stefanko DP, Green E, Liu G, Liu H, Zhang S, Kane E, Mehrad M, Spira AE, Dubinett SM, Burks EJ, Mazzilli SA, Lenburg ME, Beane JE. Archetype analysis of lung adenocarcinoma premalignancy links heterogeneity in premalignant lesions to diverging features of invasive disease. Mol Cancer Res. 2026 May 06. PMID: 42089783.
Published on 5/5/2026Souery W, Wong J, Diaz AA, Xu K, Xiao X, Liu H, Liu G, Gower AC, Alekseyev YO, Billatos E, Lenburg ME. Validation of bronchial airway gene expression associated with bronchiectasis in nasal epithelium. ERJ Open Res. 2026 May; 12(3). PMID: 42094231.
Published on 4/2/2026Ning B, Chiu DJ, Pfefferkorn RM, Cullinane E, Kefella Y, Kane E, Reyes-Ortiz V, Liu G, Zhang X, Liu H, Sultan L, Green E, Constant M, Spira AE, Campbell JD, Reid ME, Varelas X, Burks EJ, Lenburg ME, Mazzilli SA, Beane JE. Upregulation of an Epithelial miRNA Is Associated with Immune Evasion in Progressive Bronchial Premalignant Lesions. Cancer Immunol Res. 2026 Apr 02; 14(4):689-707. PMID: 41670462.
Published on 3/24/2026Steiner D, Sultan L, Sullivan T, Liu H, Xiao X, LeClerc A, Melvin S, Alekseyev YO, Liu G, Mazzilli SA, Zhang J, Suzuki K, Rieger-Christ K, Burks EJ, Beane J, Lenburg ME. Vascular invasion-associated gene expression is detectable in pre-surgical biopsies of stage I lung adenocarcinoma. Nat Commun. 2026 Mar 24; 17(1). PMID: 41876493.
Published on 2/1/2026Okajima Y, Lenburg ME, Diaz AA. When asthmatic distal airways lose their identity: a new mechanism of mucus plugs pathogenesis. Am J Respir Crit Care Med. 2026 Feb 01; 212(2):197-198. PMID: 41738085.
Published on 2/1/2026Souery WN, Billatos E, Elalami R, San José Estépar R, Cho MH, Diaz AA, Lenburg ME. Mucus plugs-associated gene expression identifies pathophysiology shared with chronic bronchitis. Am J Respir Crit Care Med. 2026 Feb 01; 212(2):253-267. PMID: 41072469.
Published on 10/6/2025Anderson KE, Tran LM, Krysan K, Kefella Y, Yu L, Fishbein GA, Rodriguez E, Shabihkhani M, Stefanko DP, Green E, Liu G, Liu H, Zhang S, Kane E, Mehrad M, Spira AE, Dubinett SM, Burks EJ, Mazzilli SA, Lenburg ME, Beane JE. Archetype analysis of lung adenocarcinoma premalignancy links heterogeneity in premalignant lesions to diverging features of invasive disease. bioRxiv. 2025 Oct 06. PMID: 41278661.
Published on 2/5/2025Ning B, Chiu DJ, Pfefferkorn RM, Kefella Y, Kane E, Reyes-Ortiz V, Liu G, Zhang S, Liu H, Sultan L, Green E, Constant M, Spira AE, Campbell JD, Reid ME, Varelas X, Burks EJ, Lenburg ME, Mazzilli SA, Beane JE. Epithelial miR-149-5p up-regulation is associated with immune evasion in progressive bronchial premalignant lesions. bioRxiv. 2025 Feb 05. PMID: 39975222.
Media Mentions
Published on 3/30/2026
Genes Linked to Lung Cancer Metastasis Identified
Published on 10/17/2022
BU researcher awarded $4.6 million U2C grant to develop innovative lung cancer biomarkers
Published on 5/17/2021
Study Identifies Genes Linked to Rapid Lung Function Decline
View full list of 3 media mentions.