Kim Vanuytsel PhD

Research Assistant Professor, Hematology & Medical Oncology

670 Albany St | (617) 358-0736
Kim Vanuytsel
Sections

Hematology & Medical Oncology

Centers

Center for Regenerative Medicine

Biography

I aim to find better solutions for sickle cell disease patients by using patient-specific induced pluripotent stem cells (iPSCs) as a versatile platform to study the disease, screen for compounds that can ameliorate the condition and explore potential curative gene editing approaches. Inherently linked to my efforts in modeling blood-borne diseases, I have a strong interest in understanding the molecular underpinnings of hematopoietic development and differentiation. My research therefore focuses on the development of tools and resources that can help us understand important concepts in hematopoietic development with the goal of translating this knowledge into the realization of the immense potential that iPSCs hold for disease modeling and regenerative medicine.

Education

PhD, Katholieke Univ Leuven, 2014

Biotechnology, MS, Katholieke Univ Leuven, 2008

Publications

Published on 10/19/2020

Wagner DE, Ikonomou L, Gilpin SE, Magin CM, Cruz F, Greaney A, Magnusson M, Chen YW, Davis B, Vanuytsel K, Rolandsson Enes S, Krasnodembskaya A, Lehmann M, Westergren-Thorsson G, Stegmayr J, Alsafadi HN, Hoffman ET, Weiss DJ, Ryan AL. Stem Cells, Cell Therapies, and Bioengineering in Lung Biology and Disease 2019. ERJ Open Res. 2020 Oct; 6(4). PMID: 33123557.

Published on 9/15/2020

Giadone RM, Mithal A, Miller GJ, Matte TM, Yeung AK, Dowrey TW, Werder RB, Miller NS, Andry CD, Vanuytsel K, Murphy GJ. qRT-PCR Platforms for Diagnosing and Reporting SARS-CoV-2 Infection in Human Samples. STAR Protoc. 2020 Sep 18; 1(2):100102. PMID: 32954369.

Published on 5/19/2020

Vanuytsel K, Mithal A, Giadone RM, Yeung AK, Matte TM, Dowrey TW, Werder RB, Miller GJ, Miller NS, Andry CD, Murphy GJ. Rapid Implementation of a SARS-CoV-2 Diagnostic Quantitative Real-Time PCR Test with Emergency Use Authorization at a Large Academic Safety Net Hospital. Med (N Y). 2020 Dec 18; 1(1):152-157.e3. PMID: 32838351.

Published on 3/18/2020

Vanuytsel K, Cai Q, Khurana S, Shetty S, Vermeesch JR, Ordovas L, Verfaillie CM. Corrigendum to "FANCA knockout in human embryonic stem cells causes a severe growth disadvantage" [Stem Cell Res.13/2 (2014) 240-50]. Stem Cell Res. 2020 04; 44:101763. PMID: 32199280.

Published on 11/7/2019

Steinberg MH, Kumar S, Murphy GJ, Vanuytsel K. Sickle cell disease in the era of precision medicine: looking to the future. Expert Rev Precis Med Drug Dev. 2019; 4(6):357-367. PMID: 33015364.

Published on 1/1/2019

Vanuytsel K, Steinberg MH, Murphy GJ. In: Haruhisa Inoue, Yukio Nakamura (Eds.), Medical Applications of iPS Cells. Recapitulating Hematopoietic Development in a Dish. 2019; 45-71.

Published on 8/14/2018

Vanuytsel K, Matte T, Leung A, Naing ZH, Morrison T, Chui DHK, Steinberg MH, Murphy GJ. Induced pluripotent stem cell-based mapping of ß-globin expression throughout human erythropoietic development. Blood Adv. 2018 08 14; 2(15):1998-2011. PMID: 30108108.

Published on 4/1/2018

Leung A, Zulick E, Skvir N, Vanuytsel K, Morrison TA, Naing ZH, Wang Z, Dai Y, Chui DHK, Steinberg MH, Sherr DH, Murphy GJ. Notch and Aryl Hydrocarbon Receptor Signaling Impact Definitive Hematopoiesis from Human Pluripotent Stem Cells. Stem Cells. 2018 07; 36(7):1004-1019. PMID: 29569827.

Published on 2/13/2018

Ordovás L, Boon R, Pistoni M, Chen Y, Wolfs E, Guo W, Sambathkumar R, Bobis-Wozowicz S, Helsen N, Vanhove J, Berckmans P, Cai Q, Vanuytsel K, Eggermont K, Vanslembrouck V, Schmidt BZ, Raitano S, Van Den Bosch L, Nahmias Y, Cathomen T, Struys T, Verfaillie CM. Efficient Recombinase-Mediated Cassette Exchange in hPSCs to Study the Hepatocyte Lineage Reveals AAVS1 Locus-Mediated Transgene Inhibition. Stem Cell Reports. 2018 02 13; 10(2):673. PMID: 29444475.

Published on 1/19/2017

Park S, Gianotti-Sommer A, Molina-Estevez FJ, Vanuytsel K, Skvir N, Leung A, Rozelle SS, Shaikho EM, Weir I, Jiang Z, Luo HY, Chui DHK, Figueiredo MS, Alsultan A, Al-Ali A, Sebastiani P, Steinberg MH, Mostoslavsky G, Murphy GJ. A Comprehensive, Ethnically Diverse Library of Sickle Cell Disease-Specific Induced Pluripotent Stem Cells. Stem Cell Reports. 2017 Apr 11; 8(4):1076-1085. PMID: 28111279.

View full list of 17 publications.