J. Michael Gaziano MD

Adjunct Professor, Cardiovascular Medicine

72 E. Concord Street
J. Michael Gaziano
Sections

Cardiovascular Medicine

Biography

Dr. Michael J. Gaziano, MD, MPH is an internationally recognized chronic disease epidemiologist and trialist. He received his MD from Yale Medical School and his MPH from the Harvard School of Public Health.

At the VA Boston Healthcare System, he is one of the Director the Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), a national epidemiology and trial center funded by CSR&D where he directs the epidemiology research center. He is national PI for the Million Veteran Program (MVP), a large project designed to enroll a million veterans into a large observational cohort with stored biospecimens. He also serves as the director of the Boston Geriatric Research and Education Center (GRECC). At VA Boston he runs a preventive cardiology program with an associated fellowship. He is the Chief of the Division of Aging at Brigham and Women’s Hospital where he is principal investigator for the ongoing Physicians' Health Study (PHS) II study, a large-scale trial of vitamins in the prevention of chronic disease. The Physicians’ Health Study cohort is comprised of 29,000 physicians who have been followed for up to 28 years. He is a Professor of Medicine at Harvard Medical School.

Dr. Gaziano’s research interests include the epidemiology of chronic diseases, with a particular interest in the roles that individual lifestyle choices (diet, exercise, smoking), metabolic factors (obesity, high cholesterol, and hypertension), and biochemical and genetic markers play on the risk of coronary artery disease and stroke. Also of interest is the impact that vascular disease has on other organ systems. Recently, Dr. Gaziano has initiated a number of research projects to investigate the diverse nature of atherosclerosis. While atherosclerosis plaques form only in certain large and medium-sized vessels, the process of atherogenesis affects arteries of all sizes. For example, renal dysfunction, cognitive decline and osteoporosis-related fractures have been linked to various cardiovascular disease risk factors, suggesting a role for small vessel disease in vascular dementia, in abnormal bone remodeling and chronic renal disease. These projects are intended to explore the extent to which atherosclerotic disease in small vessels leads to these and other chronic conditions.

He has published over 350 original reports, reviews, book chapters, and books. He teaches advanced epidemiology and has mentored over 50 trainees. He is a contributing editor for JAMA.

Education

MD, Yale University School of Medicine

MPH, Harvard School of Public Health

BA, West Virginia University

Publications

Published on 4/19/2024

Honerlaw J, Ho YL, Fontin F, Murray M, Galloway A, Heise D, Connatser K, Davies L, Gosian J, Maripuri M, Russo J, Sangar R, Tanukonda V, Zielinski E, Dubreuil M, Zimolzak AJ, Panickan VA, Cheng SC, Whitbourne SB, Gagnon DR, Cai T, Liao KP, Ramoni RB, Gaziano JM, Muralidhar S, Cho K. Centralized Interactive Phenomics Resource: an integrated online phenomics knowledgebase for health data users. J Am Med Inform Assoc. 2024 Apr 19; 31(5):1126-1134. PMID: 38481028.

Published on 4/6/2024

Gorman BR, Francis M, Nealon CL, Halladay CW, Duro N, Markianos K, Genovese G, Hysi PG, Choquet H, Afshari NA, Li YJ, Gaziano JM, Hung AM, Wu WC, Greenberg PB, Pyarajan S, Lass JH, Peachey NS, Iyengar SK. A multi-ancestry GWAS of Fuchs corneal dystrophy highlights the contributions of laminins, collagen, and endothelial cell regulation. Commun Biol. 2024 Apr 06; 7(1):418. PMID: 38582945.

Published on 4/5/2024

Wang X, Liu M, Nogues IE, Chen T, Xiong X, Bonzel CL, Zhang H, Hong C, Xia Y, Dahal K, Costa L, Cui J, Gaziano JM, Kim SC, Ho YL, Cho K, Cai T, Liao KP. Heterogeneous associations between interleukin-6 receptor variants and phenotypes across ancestries and implications for therapy. Sci Rep. 2024 Apr 05; 14(1):8021. PMID: 38580710.

Published on 3/15/2024

Bigdeli TB, Barr PB, Rajeevan N, Graham DP, Li Y, Meyers JL, Gorman BR, Peterson RE, Sayward F, Radhakrishnan K, Natarajan S, Nielsen DA, Wilkinson AV, Malhotra AK, Zhao H, Brophy M, Shi Y, O'Leary TJ, Gleason T, Przygodzki R, Pyarajan S, Muralidhar S, Gaziano JM, Huang GD, Concato J, Siever LJ, DeLisi LE, Kimbrel NA, Beckham JC, Swann AC, Kosten TR, Fanous AH, Aslan M, Harvey PD. Correlates of suicidal behaviors and genetic risk among United States veterans with schizophrenia or bipolar I disorder. Mol Psychiatry. 2024 Mar 15. PMID: 38491344.

Published on 3/8/2024

Brunette CA, Yi T, Danowski ME, Cardellino M, Harrison A, Assimes TL, Knowles JW, Christensen KD, Sturm AC, Sun YV, Hui Q, Pyarajan S, Shi Y, Whitbourne SB, Gaziano JM, Muralidhar S, Vassy JL. Development and utility of a clinical research informatics application for participant recruitment and workflow management for a return of results pilot trial in familial hypercholesterolemia in the Million Veteran Program. JAMIA Open. 2024 Apr; 7(1):ooae020. PMID: 38464744.

Published on 3/4/2024

Almuwaqqat Z, Hui Q, Liu C, Zhou JJ, Voight BF, Ho YL, Posner DC, Vassy JL, Gaziano JM, Cho K, Wilson PWF, Sun YV. Long-Term Body Mass Index Variability and Adverse Cardiovascular Outcomes. JAMA Netw Open. 2024 Mar 04; 7(3):e243062. PMID: 38512255.

Published on 2/1/2024

Elmore A, Adhikari N, Hartley AE, Javier Aparicio H, Posner DC, Hemani G, Tilling K, Gaunt TR, Wilson P, Casas JP, Michael Gaziano J, Smith GD, Paternoster L, Cho K, Peloso GM. Protein identification for stroke progression via Mendelian Randomization in Million Veteran Program and UK Biobank. medRxiv. 2024 Feb 01. PMID: 38352469.

Published on 1/8/2024

Harrington KM, Quaden R, Steele L, Helmer DA, Hauser ER, Ahmed ST, Aslan M, Radhakrishnan K, Honerlaw J, Nguyen XT, Muralidhar S, Concato J, Cho K, Gaziano JM, Whitbourne SB, On Behalf Of The Va Million Veteran Program. The Million Veteran Program 1990-1991 Gulf War Era Survey: An Evaluation of Veteran Response, Characteristics, and Representativeness of the Gulf War Era Veteran Population. Int J Environ Res Public Health. 2024 Jan 08; 21(1). PMID: 38248536.

Published on 1/4/2024

Meng X, Navoly G, Giannakopoulou O, Levey DF, Koller D, Pathak GA, Koen N, Lin K, Adams MJ, Rentería ME, Feng Y, Gaziano JM, Stein DJ, Zar HJ, Campbell ML, van Heel DA, Trivedi B, Finer S, McQuillin A, Bass N, Chundru VK, Martin HC, Huang QQ, Valkovskaya M, Chu CY, Kanjira S, Kuo PH, Chen HC, Tsai SJ, Liu YL, Kendler KS, Peterson RE, Cai N, Fang Y, Sen S, Scott LJ, Burmeister M, Loos RJF, Preuss MH, Actkins KV, Davis LK, Uddin M, Wani AH, Wildman DE, Aiello AE, Ursano RJ, Kessler RC, Kanai M, Okada Y, Sakaue S, Rabinowitz JA, Maher BS, Uhl G, Eaton W, Cruz-Fuentes CS, Martinez-Levy GA, Campos AI, Millwood IY, Chen Z, Li L, Wassertheil-Smoller S, Jiang Y, Tian C, Martin NG, Mitchell BL, Byrne EM, Awasthi S, Coleman JRI, Ripke S, Sofer T, Walters RG, McIntosh AM, Polimanti R, Dunn EC, Stein MB, Gelernter J, Lewis CM, Kuchenbaecker K. Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference. Nat Genet. 2024 Feb; 56(2):222-233. PMID: 38177345.

Published on 1/2/2024

Justice AC, Tate JP, Howland F, Gaziano JM, Kelley MJ, McMahon B, Haiman C, Wadia R, Madduri R, Danciu I, Leppert JT, Leapman MS, Thurtle D, Gnanapragasam VJ. Adaption and National Validation of a Tool for Predicting Mortality from Other Causes Among Men with Nonmetastatic Prostate Cancer. Eur Urol Oncol. 2024 Jan 02. PMID: 38171965.

View full list of 713 publications.