George J. Murphy PhD
Associate Professor, Hematology & Medical Oncology
650 Albany St | (617) 638-7520gjmurphy@bu.edu

Sections
Hematology & Medical Oncology
Centers
Center of Excellence in Sickle Cell Disease
Center for Regenerative Medicine
Pulmonary Center
Evans Center for Interdisciplinary Biomedical Research
Biography
I have developed an approach to science that utilizes multiple stem cell-based platforms to answer basic biological questions and combat human disease. My current research portfolio is a direct reflection of my evolution as a scientist in which my early studies of hematopoietic development led to the generation of useful tools and reagents as well as methodologies and insights that synergized into a potent platform in the emerging and rapidly expanding field of pluripotent stem cell biology. My group is composed of dynamic and passionate young researchers and together we have impacted the following areas of investigation:
1.) Science at the intersection of regenerative medicine and aging
2.) The generation, culture, and directed differentiation of pluripotent stem cells
3.) Understanding the molecular and functional basis of exceptional longevity: Dissecting resistance to aging-related disease
4.) Pluripotent Stem Cell Modeling of Human Disease: The ‘Clinical Trial in a Test Tube’
5.) Developmental hematopoiesis
Other Positions
Websites
Murphy Lab - Science at the Intersection of Regenerative Medicine and Aging
Center for Regenerative Medicine of Boston University & Boston Medical Center
Education
Cell & Molecular Biology, PhD, University of Oxford
Biology, BS, Trinity College
Publications
Yeung AK, Murphy GJ. The lung is a megakaryocyte outpost that can defend against thrombocytopenic attack. J Clin Invest. 2024 Nov 15; 134(22). PMID: 39545421.
Published on 9/25/2024Dowrey TW, Cranston SF, Skvir N, Lok Y, Gould B, Petrowitz B, Villar D, Shan J, James M, Dodge M, Belkina AC, Giadone RM, Milman S, Sebastiani P, Perls TT, Andersen SL, Murphy GJ. A longevity-specific bank of induced pluripotent stem cells from centenarians and their offspring. Aging Cell. 2025 Jan; 24(1):e14351. PMID: 39319670.
Published on 6/4/2024Ysasi AB, Engler AE, Bawa PS, Wang F, Conrad RD, Yeung AK, Rock JR, Beane-Ebel J, Mazzilli SA, Franklin RA, Mizgerd JP, Murphy GJ. A specialized population of monocyte-derived tracheal macrophages promote airway epithelial regeneration through a CCR2-dependent mechanism. iScience. 2024 Jul 19; 27(7):110169. PMID: 38993668.
Published on 5/7/2024Kretov DA, Folkes L, Mora-Martin A, Walawalkar IA, Imrat, Syedah N, Vanuytsel K, Moxon S, Murphy GJ, Cifuentes D. The miR-144/Hmgn2 regulatory axis orchestrates chromatin organization during erythropoiesis. Nat Commun. 2024 May 07; 15(1):3821. PMID: 38714702.
Published on 3/16/2024Edwards CV, Ferri GM, Villegas-Galaviz J, Ghosh S, Bawa PS, Wang F, Klimtchuk E, Ajayi TB, Morgan GJ, Prokaeva T, Staron A, Ruberg FL, Sanchorawala V, Giadone RM, Murphy GJ. Abnormal global longitudinal strain and reduced serum inflammatory markers in cardiac AL amyloidosis patients without significant amyloid fibril deposition. bioRxiv. 2024 Mar 16. PMID: 38558967.
Published on 3/14/2024Dowrey TW, Cranston SF, Skvir N, Lok Y, Gould B, Petrowitz B, Villar D, Shan J, James M, Dodge M, Belkina AC, Giadone RM, Sebastiani P, Perls TT, Andersen SL, Murphy GJ. A longevity-specific bank of induced pluripotent stem cells from centenarians and their offspring. bioRxiv. 2024 Mar 14. PMID: 38559230.
Published on 11/28/2023Yeung AK, Villacorta-Martin C, Lindstrom-Vautrin J, Belkina AC, Vanuytsel K, Dowrey TW, Ysasi AB, Bawa P, Wang F, Vrbanac V, Mostoslavsky G, Balazs AB, Murphy GJ. De novo hematopoiesis from the fetal lung. Blood Adv. 2023 Nov 28; 7(22):6898-6912. PMID: 37729429.
Published on 9/27/2023Hoffman SE, Dowrey TW, Villacorta Martin C, Bi K, Titchen B, Johri S, DelloStritto L, Patel M, Mackichan C, Inga S, Chen J, Grimaldi G, Napolitano S, Wakiro I, Wu J, Yeung J, Rotem A, Sicinska E, Shannon E, Clancy T, Wang J, Denning S, Brais L, Besson NR, Pfaff KL, Huang Y, Kao KZ, Rodig S, Hornick JL, Vigneau S, Park J, Kulke MH, Chan J, Van Allen EM, Murphy GJ. Intertumoral lineage diversity and immunosuppressive transcriptional programs in well-differentiated gastroenteropancreatic neuroendocrine tumors. Sci Adv. 2023 Sep 29; 9(39):eadd9668. PMID: 37756410.
Published on 7/19/2023Kretov DA, Folkes L, Mora-Martin A, Syedah N, Walawalkar IA, Vanyustel K, Moxon S, Murphy GJ, Cifuentes D. The miR-144/Hmgn2 regulatory axis orchestrates chromatin organization during erythropoiesis. bioRxiv. 2023 Jul 19. PMID: 37503141.
Published on 7/13/2023Ghosh S, Villacorta-Martin C, Lindstrom-Vautrin J, Kenney D, Golden CS, Edwards CV, Sanchorawala V, Connors LH, Giadone RM, Murphy GJ. Mapping cellular response to destabilized transthyretin reveals cell- and amyloidogenic protein-specific signatures. Amyloid. 2023 Dec; 30(4):379-393. PMID: 37439769.
Media Mentions
Published on 11/29/2024
What’s the secret to living to 100? Centenarian stem cells could offer clues
Published on 2/21/2024
Published on 12/19/2023
‘It’s just amazing to me that I’m still here’: Great-great-grandma, 105, reveals secret to long life
Published on 5/5/2023
104-year-old New Yorker reveals secret to long life: ‘I love my beer’
Published on 4/18/2023
Study: Strong immune cells may be the key to living to 100
Published on 4/7/2023
Want to live to 100? Your DNA may hold your destiny
Published on 4/6/2023
This is what you need to live to 100: DNA study
Published on 4/5/2023
‘Elite’ Immune Systems Could Be Centenarians’ Secret: Study
Published on 4/4/2023
DNA study reveals one key factor that helps some people live beyond 100
Published on 11/3/2020
Election 2020: A Day of Nervousness Turns to a Night of Uncertainty
View full list of 21 media mentions.