Esther Landesman PhD
Instructor, Hematology & Medical Oncology
650 Albany St | (617) 638-7022ebl@bu.edu
Sections
Hematology & Medical Oncology
Biography
Dr. Landesman's research has focused on studying the role of protein kinase CK2, a highly conserved and constitutively expressed serine-threonine kinase. In vitro and transgenic mouse models were used to study the role of CK2 in breast tumorigenesis and the synergism of CK2 with the absence of p53 in lymphoma development. Genetic disruption of the catalytic subunits of CK2: CK2a and CK2a’ have uncovered the impact of CK2 in mouse embryonic development. Current research attempts to characterize the consequences of compounded reduction of CK2 catalytic subunits in mice. In addition, Dr. Landesman is collaborating with Dr. Hui Feng to find targetable vulnerabilities in MYC-related cancers. Dr. Landesman-Bollag obtained her PhD and did her postdoctoral training at Chobanian and Avedisian School of Medicine in the laboratory of the late Dr. David Seldin. She is Instructor of Hematology & Medical Oncology at Chobanian and Avedisian School of Medicine.
Education
Pathology, PhD, Boston University
Veterinary Science, MS, The Hebrew University of Jerusalem
Nutrition/Food Science, BS, The Hebrew University of Jerusalem
Publications
Sicinska E, Kola VSR, Kerfoot JA, Taddei ML, Al-Ibraheemi A, Hsieh YH, Church AJ, Landesman-Bollag E, Landesman Y, Hemming ML. ASPSCR1::TFE3 Drives Alveolar Soft Part Sarcoma by Inducing Targetable Transcriptional Programs. Cancer Res. 2024 Jul 15; 84(14):2247-2264. PMID: 38657118.
Published on 2/7/2024Xiao B, Landesman-Bollag E, Feng H. What value do zebrafish have to anticancer drug discovery? Expert Opin Drug Discov. 2024 Apr; 19(4):369-375. PMID: 38327017.
Published on 1/15/2022Wang Q, Feng L, Zhang H, Gao J, Mao C, Landesman-Bollag E, Mostoslavsky G, Lunderberg JM, Zheng W, Hao S, Gao W. Longitudinal waning of mRNA vaccine-induced neutralizing antibodies against SARS-CoV-2 detected by an LFIA rapid test. Antib Ther. 2022 Jan; 5(1):55-62. PMID: 35146332.
Published on 9/23/2021Shibad V, Bootwala A, Mao C, Bader H, Vo H, Landesman-Bollag E, Guo C, Rubio A, Near R, Gao W, Challa S, Chukka V, Gao J, Kelly A, Landesman T, VanHelene T, Zhong X. L2pB1 Cells Contribute to Tumor Growth Inhibition. Front Immunol. 2021; 12:722451. PMID: 34630396.
Published on 5/1/2021Zhou Y, Lian H, Shen N, Korm S, Kwok Ping Lam A, Layton O, Huiting LN, Li D, Miao K, Zeng A, Landesman-Bollag E, Seldin DC, Fu H, Hong L, Feng H. The multifaceted role of protein kinase CK2 in high-risk acute lymphoblastic leukemia. Haematologica. 2021 05 01; 106(5):1461-1465. PMID: 32817283.
Published on 10/6/2016Lian H, Li D, Zhou Y, Landesman-Bollag E, Zhang G, Anderson NM, Tang KC, Roderick JE, Kelliher MA, Seldin DC, Fu H, Feng H. CK2 inhibitor CX-4945 destabilizes NOTCH1 and synergizes with JQ1 against human T-acute lymphoblastic leukemic cells. Haematologica. 2017 01; 102(1):e17-e21. PMID: 27758824.
Published on 8/29/2016Novikov O, Wang Z, Stanford EA, Parks AJ, Ramirez-Cardenas A, Landesman E, Laklouk I, Sarita-Reyes C, Gusenleitner D, Li A, Monti S, Manteiga S, Lee K, Sherr DH. An Aryl Hydrocarbon Receptor-Mediated Amplification Loop That Enforces Cell Migration in ER-/PR-/Her2- Human Breast Cancer Cells. Mol Pharmacol. 2016 Nov; 90(5):674-688. PMID: 27573671.
Published on 3/16/2016Stanford EA, Wang Z, Novikov O, Mulas F, Landesman-Bollag E, Monti S, Smith BW, Seldin DC, Murphy GJ, Sherr DH. The role of the aryl hydrocarbon receptor in the development of cells with the molecular and functional characteristics of cancer stem-like cells. BMC Biol. 2016 Mar 16; 14:20. PMID: 26984638.
Published on 10/10/2012Romagnoli M, Belguise K, Yu Z, Wang X, Landesman-Bollag E, Seldin DC, Chalbos D, Barillé-Nion S, Jézéquel P, Seldin ML, Sonenshein GE. Epithelial-to-mesenchymal transition induced by TGF-ß1 is mediated by Blimp-1-dependent repression of BMP-5. Cancer Res. 2012 Dec 1; 72(23):6268-78. PMID: 23054396.
Published on 7/19/2011Landesman-Bollag E, Belkina A, Hovey B, Connors E, Cox C, Seldin DC. Developmental and growth defects in mice with combined deficiency of CK2 catalytic genes. Mol Cell Biochem. 2011 Oct; 356(1-2):227-31. PMID: 21769451.