Elizabeth S. Klings MD

Professor, Pulmonary, Allergy, Sleep & Critical Care Medicine

72 E. Concord Street | (617) 638-8679
Elizabeth Klings
Sections

Pulmonary, Allergy, Sleep & Critical Care Medicine

Centers

Center of Excellence in Sickle Cell Disease

Pulmonary Center

Evans Center for Interdisciplinary Biomedical Research

Biography

Dr. Klings is an Associate Professor in the Department of Medicine. She is the Director of the Center for Excellence in Sickle Cell Disease and the Director of the Pulmonary Hypertension at BUSM/Boston Medical Center. She has an outpatient clinical practice focused on patients with pulmonary hypertension and those with pulmonary complications of sickle cell disease. She attends in the Medical Intensive Care Unit and on the Pulmonary Hypertension Consultation Service at Boston Medical Center. As Director of the largest sickle cell center in New England, Dr. Klings has created numerous new clinical programs for our patients and has expanded the clinical trials program.

Dr. Klings’ research since fellowship has focused on pathogenesis of pulmonary vascular complications of sickle cell disease. She is an NIH-funded Principal Investigator .in the Pulmonary Center collaborating with numerous other investigators across the medical campus. She has phenotypically screened over 200 sickle cell patients at Boston Medical Center for the presence of pulmonary hypertension and currently investigating the roles of disease modulators including sleep-disordered breathing and venous thromboembolism in the endothelial and vascular dysfunction these patients experience. Known internationally as a leader in the care and treatment of patients with sickle cell disease, she was first author of the American Thoracic Society sponsored clinical guidelines for Diagnosis and Treatment of Pulmonary Hypertension in Sickle Cell Disease. She recently chaired an ATS sponsored workshop to define clinical and research priorities in sickle cell lung disease and serves on the NHLBI Sickle Cell Disease Advisory Committee.

Education

MD, New York University School of Medicine

Biology, BA, New York University

Publications

Published on 12/9/2024

Lui JK, Cozzolino M, Winburn M, Trojanowski MA, Soylemez Wiener R, LaValley MP, Bujor AM, Gopal DM, Klings ES. Clustering regional patterns of left ventricular longitudinal strain in systemic sclerosis-related pulmonary hypertension. Int J Cardiol. 2025 Feb 15; 421:132891. PMID: 39662748.

Published on 12/6/2024

Katbamna B, Wu L, Rodriguez M, King P, Schilling J, Mahar J, Nair AP, Jneid H, Klings ES, Weinhouse GL, Mazimba S, Simon MA, Strauss M, Krittanawong C. The uses of right heart catheterization in cardio-pulmonary disease: State-of-the-art. Am Heart J Plus. 2025 Jan; 49:100488. PMID: 39760109.

Published on 11/1/2024

Alwang AK, Law AC, Klings ES, Cohen RT, Bosch NA. Lactated Ringer vs Normal Saline Solution During Sickle Cell Vaso-Occlusive Episodes. JAMA Intern Med. 2024 Nov 01; 184(11):1365-1372. PMID: 39250114.

Published on 10/29/2024

Walters MC, Eapen M, Liu Y, El Rassi F, Waller EK, Levine JE, Strouse JJ, Antin JH, Parikh SH, Bakshi N, Dampier CD, Jaroscak JJ, Bergmann S, Wong TE, Kota VK, Pace BS, Lekakis LJ, Lulla PD, Nickel R, Kasow KA, Popat UR, Smith WR, Yu LC, DiFronzo NL, Geller NL, Kamani N, Klings ES, Hassell K, Mendizabal AM, Sullivan K, Neuberg DS, Krishnamurti L. Hematopoietic Cell Transplant compared with Standard Care in Adolescents and Young Adults with Sickle Cell Disease. Blood Adv. 2024 Oct 29. PMID: 39471440.

Published on 6/19/2024

Cohen RT, Burrowes SAB, Williams CJ, Neri CM, Klings ES, Jones KC, Walkey AJ, Drainoni ML. SNAP: Supportive non-invasive ventilation for acute chest syndrome prevention for hospitalized children with sickle cell disease: Perspectives of patients, parents, and the healthcare team. Pediatr Blood Cancer. 2024 Sep; 71(9):e31142. PMID: 38896013.

Published on 6/1/2024

Lui JK, Sangani RA, Gillmeyer KR, Vakhshoorzadeh J, Trojanowski MA, Bujor AM, Gopal DM, Wiener RS, LaValley MP, Klings ES. Correction to: Hemodynamic Response to Oral Vasodilator Therapy in Systemic Sclerosis-Related Pulmonary Hypertension. Cardiovasc Drugs Ther. 2024 Jun; 38(3):657. PMID: 36662449.

Published on 5/20/2024

Johnson SW, Wang RS, Winter MR, Gillmeyer KR, Zeder K, Klings ES, Goldstein RH, Wiener RS, Maron BA. Cluster analysis identifies novel real-world lung disease-pulmonary hypertension subphenotypes: implications for treatment response. ERJ Open Res. 2024 May; 10(3). PMID: 38770008.

Published on 5/1/2024

Siskind SM, Johnson TY, Klings ES, Modzelewski KL. Diabetes Screening Rates and Practices in Patients With Sickle Cell Disease. Diabetes Care. 2024 May 01; 47(5):e42-e43. PMID: 38489046.

Published on 3/27/2024

Gladwin MT, Gordeuk VR, Desai PC, Minniti C, Novelli EM, Morris CR, Ataga KI, De Castro L, Curtis SA, El Rassi F, Ford HJ, Harrington T, Klings ES, Lanzkron S, Liles D, Little J, Nero A, Smith W, Taylor JG, Baptiste A, Hagar W, Kanter J, Kinzie A, Martin T, Rafique A, Telen MJ, Lalama CM, Kato GJ, Abebe KZ. Riociguat in patients with sickle cell disease and hypertension or proteinuria (STERIO-SCD): a randomised, double-blind, placebo controlled, phase 1-2 trial. Lancet Haematol. 2024 May; 11(5):e345-e357. PMID: 38554715.

Published on 3/11/2024

Zheng R, Solomon A, DiLorenzo M, Rajendran I, Park J, Dhongade V, Garcia MA, Eberhardt RT, Sloan JM, Weinberg J, Klings ES. The Association of Anticoagulation Intensity with Outcomes in Hospitalized COVID-19 Patients. Adv Hematol. 2024; 2024:8838308. PMID: 38500844.

View full list of 96 publications.