Daniel Levy MD
Professor, Preventive Medicine & Epidemiology
Director, FHS, National Heart, Lung and Blood Institute
73 Mt Wayte Ave | (508) 935-3458levyd@nih.gov
Sections
Preventive Medicine & Epidemiology
Centers
Framingham Heart Study
Biography
Daniel Levy received a B.A. from the University of Pennsylvania in 1976 and an M.D. from Chobanian and Avedisian School of Medicine in 1980. He then completed his residency in internal medicine at University Hospital, Boston and a research fellowship in cardiology at Brigham and Women’s Hospital and Harvard School of Public Health. He joined the NHLBI’s Framingham Heart Study in 1984 and became the Study’s fourth director in 1994. Dr. Levy is also jointly a professor of medicine at Chobanian and Avedisian School of Medicine and holds an adjunct faculty appointment at Harvard Medical School. Dr. Levy has been the recipient of many awards for his research accomplishments including two NIH Director’s Awards and the American Heart Association’s Population Research Prize in 2009, the AHA’s highest recognition for research achievements in epidemiology. Dr. Levy is a fellow of the American College of Cardiology and American Heart Association, and he is also a member of the American Society of Hypertension and Heart Failure Society of America. Dr. Levy is currently Editor-in-Chief of the journal Current Cardiovascular Risk Reports. He has published over 400 articles in leading medical journals, as well as two books and several book chapters.
Education
MD, Boston University School of Medicine
BA, University of Pennsylvania
Publications
Yang J, Ogunsola S, Wong J, Wang A, Joehanes R, Levy D, Sharma S, Liu C, Xie J. A mammalian genomic signature shaped by single nucleotide variants regulates transcriptome integrity and diversity. Genome Biol. 2026 Apr 29. PMID: 42057098.
Published on 3/5/2026Leng Y, Ding H, Li Y, Liu X, Wang M, Cao Y, Lyu C, Levy D, Ma J, Liu C. Sex-Specific Fifteen-Year Alcohol Consumption Trajectories and Their Association with Cardiovascular Events and Mortality: The Framingham Heart Study. Nutrients. 2026 Mar 05; 18(5). PMID: 41830019.
Published on 1/25/2026Sun X, Liu X, Bulekova K, Pitsillides AN, Guo X, Yong Q, Raffield LM, Rotter JI, Rich SS, Abecasis G, Carson AP, Vasan RS, Bis JC, Psaty BM, Boerwinkle E, Fitzpatrick AL, Satizabal CL, Arking DE, Ding J, Levy D, Liu C. ASSOCIATION ANALYSIS OF MITOCHONDRIAL HETEROPLASMIC VARIANTS AND CARDIOMETABOLIC TRAITS. medRxiv. 2026 Jan 25. PMID: 41659078.
Published on 1/12/2026Zhang Y, Joehanes R, Huan T, Weber LM, Yang Q, Lunetta KL, Levy D, Liu C. Integration of latent factor analysis into multivariable Mendelian randomization. Eur J Epidemiol. 2026 Jan 12. PMID: 41524881.
Published on 11/22/2025Liu C, Joehanes R, Ma J, Xie J, Yang J, Wang M, Huan T, Hwang SJ, Wen J, Sun Q, Demirkale CY, Heard-Costa NL, Orchard P, Carson AP, Haessler JW, Raffield LM, Reiner AP, Franceschini N, Auer PL, Kooperberg C, Li Y, O'Connor G, Murabito JM, Munson P, Levy D. Integrating whole genome and transcriptome sequencing to characterize the genetic architecture of isoform variation. Nat Commun. 2025 Nov 22; 16(1):10615. PMID: 41274869.
Published on 10/24/2025Wang M, Zheng Y, Lai M, Saake E, Liu X, Guo X, Taylor KD, Huan T, Joehanes R, Nannini DR, Zhang K, Lake NJ, Castellani CA, Rich SS, Rotter JI, Liu Y, Raffield LM, Carson AP, Fornage M, Ma J, Arking DE, Hou L, Levy D, Liu C. Association of Epigenetic Age Acceleration and Mitochondrial DNA-Based Aging Metrics Provides Insights Into Mechanisms of Aging-Related Diseases. Aging Cell. 2025 Dec; 24(12):e70279. PMID: 41132105.
Published on 5/20/2025Kirmani S, Huan T, Van Amburg JC, Joehanes R, Uddin MM, Nguyen NQH, Yu B, Brody JA, Fornage M, Bressler J, Sotoodehnia N, Ong DA, Puddu F, Floyd JS, Ballantyne CM, Psaty BM, Raffield LM, Natarajan P, Conneely KN, Weinstock JS, Carson AP, Lange LA, Ferrier K, Heard-Costa NL, Murabito J, Bick AG, Levy D. Epigenome-wide DNA methylation association study of CHIP provides insight into perturbed gene regulation. Nat Commun. 2025 May 20; 16(1):4678. PMID: 40393957.
Published on 11/22/2024Aggarwal M, Hwang SJ, Lee DH, Huan T, McNeill JN, Courchesne P, Joehanes R, Ho JE, Dupuis J, Hedman ÅK, O'Connor G, Levy D. Plasma Protein Biomarkers of Spirometry Measures of Impaired Lung Function. Chest. 2025 Jun; 167(6):1557-1577. PMID: 39580111.
Published on 9/7/2024Sun X, Bulekova K, Yang J, Lai M, Pitsillides AN, Liu X, Zhang Y, Guo X, Yong Q, Raffield LM, Rotter JI, Rich SS, Abecasis G, Carson AP, Vasan RS, Bis JC, Psaty BM, Boerwinkle E, Fitzpatrick AL, Satizabal CL, Arking DE, Ding J, Levy D, Liu C. Association analysis of mitochondrial DNA heteroplasmic variants: Methods and application. Mitochondrion. 2024 Nov; 79:101954. PMID: 39245194.
Published on 4/12/2024Lyu C, Joehanes R, Huan T, Levy D, Li Y, Wang M, Liu X, Liu C, Ma J. Enhancing selection of alcohol consumption-associated genes by random forest. Br J Nutr. 2024 Jun 28; 131(12):2058-2067. PMID: 38606596.