Chunlei Zheng PhD
Assistant Professor, General Internal Medicine
801 Massachusetts Ave | (216) 482-5101chunleiz@bu.edu
Sections
General Internal Medicine
Biography
Chunlei Zheng is an Assistant Professor of Medicine at Chobanian and Avedisian School of Medicine. He is also a Health Science Specialist at VA Boston Healthcare System. Dr. Zheng completed his PhD in Biophysics at Chinese Academy of Sciences. After graduation, he moved to Cleveland Clinic, where he received a postdoctoral fellowship from American Heart Association to study the protein trafficking in human diseases. Before joining Boston University, Dr. Zheng is a research scientist at Case Western Reserve University, where he received intensive biomedical informatics training.
With solid background in biology and medicine and expertise in genomics, computer science, and statistics, Dr. Zheng has great passion for data-driven biomedical discovery. In particular, he has great interest on developing/applying computational algorithm, machine learning and statistical modeling into large-scale biomedical data to facilitate disease understanding and drug discovery. Currently, his research focuses on using artificial intelligence (AI) on Alzheimer’s Disease and Cancer.
Education
PhD, Chinese Academy of Sciences
Biology, BS, Shaanxi Normal University
Publications
Zheng C, Khan A, Ritter D, Marks DS, Do NV, Fillmore NR, Sander C. Pancreatic cancer risk prediction using deep sequential modeling of longitudinal diagnostic and medication records. Cell Rep Med. 2025 Sep 16; 6(9):102359. PMID: 40961920.
Published on 8/16/2025Schuster E, Dashzeveg NK, Tong F, Jia Y, El-Shennawy L, Zhang T, Hoffman AD, Kitata RB, Kibria G, Zhang Y, Squires JR, Zheng C, Ramos E, Taftaf R, Scholten D, Almubarak HF, Adorno-Cruz V, Sullivan DP, Reduzzi C, Minor AC, Purev-Ochir W, Spahija S, Xu R, Siziopikou KP, Platanias LC, Shah A, Muller WA, Gradishar WJ, Cristofanilli M, Tsai CF, Shi T, Liu H. Computational ranking identifies Plexin-B2 in circulating tumor cell clustering with monocytes in breast cancer metastasis. Nat Commun. 2025 Aug 16; 16(1):7649. PMID: 40818975.
Published on 4/1/2025Larsen JR, Zheng C, La J, Wu JT, Kelley M, Gaziano JM, Brophy M, Do NV, Kim DH, Driver JA, DuMontier C, Fillmore NR. Multimorbidity and Its Impact in Older U.S. Veterans Newly Treated for Advanced Non-Small Cell Lung Cancer. Ann Am Thorac Soc. 2025 Apr; 22(4):598-608. PMID: 39680869.
Published on 12/16/2024Pu JJ, Berger KN, Zheng C, Do N, Claxton DF, Ehmann WC, Drabick JJ, Li H, Loughran TP, Epner EM. A phase I study using bortezomib (Velcade), cladribine, and rituximab in treating patients over 50 years old with mantle cell lymphoma. Front Oncol. 2024; 14:1449401. PMID: 39737396.
Published on 5/8/2024Ramos-Cejudo J, Corrigan JK, Zheng C, Swinnerton KN, Jacobson SR, La J, Betensky RA, Osorio RS, Madanes S, Pomara N, Iosifescu D, Brophy M, Do NV, Fillmore NR. Antidepressant exposure and long-term dementia risk in a nationwide retrospective study on US veterans with midlife major depressive disorder. Alzheimers Dement. 2024 Jun; 20(6):4106-4114. PMID: 38717046.
Published on 1/25/2024Do NV, Elbers DC, Fillmore NR, Ajjarapu S, Bergstrom SJ, Bihn J, Corrigan JK, Dhond R, Dipietro S, Dolgin A, Feldman TC, Goryachev SD, Huhmann LB, La J, Marcantonio PA, McGrath KM, Miller SJ, Nguyen VQ, Schneeloch GR, Sung FC, Swinnerton KN, Tarren AH, Tosi HM, Valley D, Vo AD, Yildirim C, Zheng C, Zwolinski R, Sarosy GA, Loose D, Shannon C, Brophy MT. Matching Patients to Accelerate Clinical Trials (MPACT): Enabling Technology for Oncology Clinical Trial Workflow. Stud Health Technol Inform. 2024 Jan 25; 310:1086-1090. PMID: 38269982.
Published on 7/10/2023Chen C, Luo L, Zheng C, Ding P, Liu H, Luo H. Self-prediction of relations in GO facilitates its quality auditing. J Biomed Inform. 2023 Aug; 144:104441. PMID: 37437682.
Published on 5/8/2023Placido D, Yuan B, Hjaltelin JX, Zheng C, Haue AD, Chmura PJ, Yuan C, Kim J, Umeton R, Antell G, Chowdhury A, Franz A, Brais L, Andrews E, Marks DS, Regev A, Ayandeh S, Brophy MT, Do NV, Kraft P, Wolpin BM, Rosenthal MH, Fillmore NR, Brunak S, Sander C. A deep learning algorithm to predict risk of pancreatic cancer from disease trajectories. Nat Med. 2023 May; 29(5):1113-1122. PMID: 37156936.
Published on 4/26/2022Ramos-Cejudo J, Johnson AD, Beiser A, Seshadri S, Salinas J, Berger JS, Fillmore NR, Do N, Zheng C, Kovbasyuk Z, Ardekani BA, Nunzio P, Bubu OM, Parekh A, Convit A, Betensky RA, Wisniewski TM, Osorio RS. Platelet Function Is Associated With Dementia Risk in the Framingham Heart Study. J Am Heart Assoc. 2022 May 03; 11(9):e023918. PMID: 35470685.
Published on 4/14/2022Zhang Y, Zhu M, Zheng C, Wei W, Emmer BT, Zhang B. LMAN1-MCFD2 complex is a cargo receptor for the ER-Golgi transport of a1-antitrypsin. Biochem J. 2022 Apr 14; 479(7):839-855. PMID: 35322856.