Christos Mantzoros MD, DSc, PhD

Adjunct Professor, General Internal Medicine

Voluntary Professor, Medicine

72 E. Concord Street | (617) 638-5300
Christos Mantzoros

General Internal Medicine


Christos S. Mantzoros, MD, DSc, PhD h.c. mult., is a Professor of Medicine at Harvard Medical School and an Adjunct Professor at Chobanian and Avedisian School of Medicine. He has also served as a Professor of Environmental Health at the Harvard School of Public Health. He currently serves as the Chief of Endocrinology, Diabetes and Metabolism at the Boston VA Healthcare System and the Director of the Human Nutrition Unit of the Division of Endocrinology Diabetes and Metabolism at Beth Israel Deaconess Medical Center. Dr. Mantzoros has been the editor of two books (one on “Diabetes and Obesity” and one on “Nutrition and Metabolism” with more than two editions each). His research has resulted in more than 800 publications in Medline, including more than 150 publications under the collaborative Look Ahead Research Group, more than 200 chapters and reviews, with more than 72,000 citations with a Hirsch Index H=121. Dr. Mantzoros is also the director for the VA Boston Healthcare System fellowship program with Boston University Medical Center (BUMC), which offers one dedicated fellowship position through BUMC, but also allows any fellow at BUMC or Harvard affiliated fellowship programs the opportunity to rotate through the VA Boston Healthcare System. He has served as a Board Member or an advisor or head of the Scientific Advisor Board of non for profit foundations as well as governmental and non-governmental entities. He is the Editor-in-Chief of the journal Metabolism and is on the editorial board of several scientific journals worldwide. For his research discoveries and public health service Dr. Mantzoros has received four honorary PhDs, the Alexander Technological Institute of Thessaloniki has named their nutrition laboratories after his name and several Universities worldwide have awarded Dr. Mantzoros honorary Professorships and visiting Professorships. He has or is supervising PhD thesis work in several nations worldwide (Sweden, Germany, Greece, USA etc) and is actively collaborating with many research groups worldwide. He has mentored more than 160 young scientists who currently hold key positions in clinical medicine, academia, industry as well as governmental agencies and nongovernmental organizations. Dr. Mantzoros has been elected a member of ASCI and a Fellow of the American College of Physicians and the American Association of Clinical Endocrinology. He has been given several awards including but not limited to awards by: the American Association of Clinical Endocrinology (Frontiers in Science Award), the American Diabetes Association (Novartis Award in Diabetes and Metabolic Diseases), the North American Association for the Study of Obesity / the Obesity Society (Lilly Award), the American Society for Nutrition (Mead Johnson Award), the HypoCCS award in Paris, France, the Humboldt Foundation of Germany (the Wilhelm Friedrich Bessel Award), by the American Federation of Medical Research (the Outstanding Investigator Award), by the American Physiological Society (FASEB, the Berson Award Lecture), by the New England Hellenic Medical and Dental Association (Hygeia award) etc. He has also received the BIDMC, Harvard Medical School, award for excellence in Mentoring. He will be receiving the 2018 European Society of Endocrinology Geoffrey Harris Prize.

Other Positions


Medicine, MD, University of Athens, 1987

Epidemiology, DSc, University of Athens, 1996

Clinical Evaluation/Research, MMS/MMSc, Harvard Medical School, 1997

Epidemiology, MSc, Harvard School of Public Health, 1997


Published on 5/8/2023

Seo YG, Polyzos SA, Park KH, Mantzoros CS. Fibrosis-4 index predicts long-term all-cause, cardiovascular and liver-related mortality in the adult Korean population. Clin Gastroenterol Hepatol. 2023 May 08. PMID: 37164111.

Published on 4/11/2023

Becerra LA, Gavrieli A, Khan F, Novak P, Lioutas V, Ngo LH, Novak V, Mantzoros CS. Daily intranasal insulin at 40IU does not affect food intake and body composition: A placebo-controlled trial in older adults over a 24-week period with 24-weeks of follow-up. Clin Nutr. 2023 Apr 11; 42(6):825-834. PMID: 37084469.

Published on 4/5/2023

Larsson SC, Michaëlsson K, Mola-Caminal M, Höijer J, Mantzoros CS. Corrigendum to "Genome-wide association and Mendelian randomization study of fibroblast growth factor 21 reveals causal associations with hyperlipidemia and possibly NASH" [Metab Volume 137, December 2022, 155329]. Metabolism. 2023 Jun; 143:155555. PMID: 37023631.

Published on 3/20/2023

Hoffmann C, Schwarz PE, Mantzoros CS, Birkenfeld AL, Wolfrum C, Solimena M, Bornstein SR, Perakakis N. Circulating levels of gastrointestinal hormones in prediabetes reversing to normoglycemia or progressing to diabetes in a year-A cross-sectional and prospective analysis. Diabetes Res Clin Pract. 2023 Mar 20; 199:110636. PMID: 36940795.

Published on 3/20/2023

Hoffmann C, Schwarz PE, Mantzoros CS, Birkenfeld AL, Wolfrum C, Solimena M, Bornstein SR, Perakakis N. Circulating levels of gastrointestinal hormones in prediabetes reversing to normoglycemia or progressing to diabetes in a year-A cross-sectional and prospective analysis. Diabetes Res Clin Pract. 2023 May; 199:110636. PMID: 36940795.

Published on 3/20/2023

Chakhtoura M, Haber R, Ghezzawi M, Rhayem C, Tcheroyan R, Mantzoros CS. Pharmacotherapy of obesity: an update on the available medications and drugs under investigation. EClinicalMedicine. 2023 Apr; 58:101882. PMID: 36992862.

Published on 3/7/2023

Chew NWS, Ng CH, Tan DJH, Kong G, Lin C, Chin YH, Lim WH, Huang DQ, Quek J, Fu CE, Xiao J, Syn N, Foo R, Khoo CM, Wang JW, Dimitriadis GK, Young DY, Siddiqui MS, Lam CSP, Wang Y, Figtree GA, Chan MY, Cummings DE, Noureddin M, Wong VW, Ma RCW, Mantzoros CS, Sanyal A, Muthiah MD. The global burden of metabolic disease: Data from 2000 to 2019. Cell Metab. 2023 Mar 07; 35(3):414-428.e3. PMID: 36889281.

Published on 1/22/2023

Raptis DD, Mantzoros CS, Polyzos SA. Fibroblast Growth Factor-21 as a Potential Therapeutic Target of Nonalcoholic Fatty Liver Disease. Ther Clin Risk Manag. 2023; 19:77-96. PMID: 36713291.

Published on 12/30/2022

Anastasilakis AD, Polyzos SA, Rodopaios NE, Makras P, Kumar A, Kalra B, Mantzoros CS. Activins, follistatins and inhibins in postmenopausal osteoporosis: A proof of concept, case-control study. Metabolism. 2023 Apr; 141:155397. PMID: 36587801.

Published on 12/22/2022

Gasbarrino K, Hafiane A, Gianopoulos I, Zheng H, Mantzoros CS, Daskalopoulou SS. Relationship between circulating adipokines and cholesterol efflux in subjects with severe carotid atherosclerosis. Metabolism. 2023 Mar; 140:155381. PMID: 36566801.

View full list of 659 publications.