Christos Mantzoros MD, DSc, PhD

Adjunct Professor, General Internal Medicine

Professor, Medicine

72 E. Concord Street | (617) 638-5300
Christos Mantzoros

General Internal Medicine


Christos S. Mantzoros, MD, DSc, PhD h.c. mult., is a Professor of Medicine at Harvard Medical School and an Adjunct Professor at Chobanian and Avedisian School of Medicine. He has also served as a Professor of Environmental Health at the Harvard School of Public Health. He currently serves as the Chief of Endocrinology, Diabetes and Metabolism at the Boston VA Healthcare System and the Director of the Human Nutrition Unit of the Division of Endocrinology Diabetes and Metabolism at Beth Israel Deaconess Medical Center. Dr. Mantzoros has been the editor of two books (one on “Diabetes and Obesity” and one on “Nutrition and Metabolism” with more than two editions each). His research has resulted in more than 800 publications in Medline, including more than 150 publications under the collaborative Look Ahead Research Group, more than 200 chapters and reviews, with more than 72,000 citations with a Hirsch Index H=121. Dr. Mantzoros is also the director for the VA Boston Healthcare System fellowship program with Boston University Medical Center (BUMC), which offers one dedicated fellowship position through BUMC, but also allows any fellow at BUMC or Harvard affiliated fellowship programs the opportunity to rotate through the VA Boston Healthcare System. He has served as a Board Member or an advisor or head of the Scientific Advisor Board of non for profit foundations as well as governmental and non-governmental entities. He is the Editor-in-Chief of the journal Metabolism and is on the editorial board of several scientific journals worldwide. For his research discoveries and public health service Dr. Mantzoros has received four honorary PhDs, the Alexander Technological Institute of Thessaloniki has named their nutrition laboratories after his name and several Universities worldwide have awarded Dr. Mantzoros honorary Professorships and visiting Professorships. He has or is supervising PhD thesis work in several nations worldwide (Sweden, Germany, Greece, USA etc) and is actively collaborating with many research groups worldwide. He has mentored more than 160 young scientists who currently hold key positions in clinical medicine, academia, industry as well as governmental agencies and nongovernmental organizations. Dr. Mantzoros has been elected a member of ASCI and a Fellow of the American College of Physicians and the American Association of Clinical Endocrinology. He has been given several awards including but not limited to awards by: the American Association of Clinical Endocrinology (Frontiers in Science Award), the American Diabetes Association (Novartis Award in Diabetes and Metabolic Diseases), the North American Association for the Study of Obesity / the Obesity Society (Lilly Award), the American Society for Nutrition (Mead Johnson Award), the HypoCCS award in Paris, France, the Humboldt Foundation of Germany (the Wilhelm Friedrich Bessel Award), by the American Federation of Medical Research (the Outstanding Investigator Award), by the American Physiological Society (FASEB, the Berson Award Lecture), by the New England Hellenic Medical and Dental Association (Hygeia award) etc. He has also received the BIDMC, Harvard Medical School, award for excellence in Mentoring. He will be receiving the 2018 European Society of Endocrinology Geoffrey Harris Prize.

Other Positions


Medicine, MD, University of Athens

Epidemiology, DSc, University of Athens

Clinical Evaluation/Research, MMS/MMSc, Harvard Medical School

Epidemiology, MSc, Harvard School of Public Health


Published on 11/4/2023

Boutari C, Kokkorakis M, Stefanakis K, Valenzuela-Vallejo L, Axarloglou E, Volcanšek Š, Chakhtoura M, Mantzoros CS. Recent research advances in metabolism, clinical and experimental. Metabolism. 2023 Dec; 149:155722. PMID: 37931873.

Published on 11/3/2023

Polyzos SA, Mantzoros CS. Sarcopenia: still in relative definition-penia and severe treatment-penia. Metabolism. 2023 Nov 03; 150:155717. PMID: 37923006.

Published on 9/25/2023

Valenzuela-Vallejo L, Chrysafi P, Kouvari M, Guatibonza-Garcia V, Mylonakis SC, Katsarou A, Verrastro O, Markakis G, Eslam M, Papatheodoridis G, Mingrone G, George J, Mantzoros CS. Circulating hormones in biopsy-proven steatotic liver disease and steatohepatitis: A Multicenter Observational Study. Metabolism. 2023 Nov; 148:155694. PMID: 37757973.

Published on 9/25/2023

Kokkorakis M, Folkertsma P, van Dam S, Sirotin N, Taheri S, Chagoury O, Idaghdour Y, Henning RH, Forte JC, Mantzoros CS, de Vries DH, Wolffenbuttel BHR. Effective questionnaire-based prediction models for type 2 diabetes across several ethnicities: a model development and validation study. EClinicalMedicine. 2023 Oct; 64:102235. PMID: 37936659.

Published on 9/7/2023

Kokkorakis M, Katsarou A, Katsiki N, Mantzoros CS. Milestones in the journey towards addressing obesity; Past trials and triumphs, recent breakthroughs, and an exciting future in the era of emerging effective medical therapies and integration of effective medical therapies with metabolic surgery. Metabolism. 2023 Nov; 148:155689. PMID: 37689110.

Published on 8/9/2023

Kouvari M, Mylonakis SC, Katsarou A, Valenzuela-Vallejo L, Guatibonza-Garcia V, Kokkorakis M, Verrastro O, Angelini G, Markakis G, Eslam M, George J, Papatheodoridis G, Mingrone G, Mantzoros CS. The first external validation of the Dallas steatosis index in biopsy-proven Non-alcoholic fatty liver Disease: A multicenter study. Diabetes Res Clin Pract. 2023 Sep; 203:110870. PMID: 37567510.

Published on 8/8/2023

Demir M, Bornstein SR, Mantzoros CS, Perakakis N. Liver fat as risk factor of hepatic and cardiometabolic diseases. Obes Rev. 2023 Oct; 24(10):e13612. PMID: 37553237.

Published on 8/4/2023

Polyzos SA, Vachliotis ID, Mantzoros CS. Sarcopenia, sarcopenic obesity and nonalcoholic fatty liver disease. Metabolism. 2023 Oct; 147:155676. PMID: 37544590.

Published on 7/30/2023

Kouvari M, Valenzuela-Vallejo L, Guatibonza-Garcia V, Polyzos SA, Deng Y, Kokkorakis M, Agraz M, Mylonakis SC, Katsarou A, Verrastro O, Markakis G, Eslam M, Papatheodoridis G, George J, Mingrone G, Mantzoros CS. Liver biopsy-based validation, confirmation and comparison of the diagnostic performance of established and novel non-invasive steatotic liver disease indexes: Results from a large multi-center study. Metabolism. 2023 Oct; 147:155666. PMID: 37527759.

Published on 7/28/2023

Kokkorakis M, Boutari C, Katsiki N, Mantzoros CS. From non-alcoholic fatty liver disease (NAFLD) to steatotic liver disease (SLD): an ongoing journey towards refining the terminology for this prevalent metabolic condition and unmet clinical need. Metabolism. 2023 Oct; 147:155664. PMID: 37517792.

View full list of 678 publications.