Alice K. Jacobs MD

Professor, Cardiovascular Medicine

88 E. Newton St | (617) 638-8707
Alice Jacobs

Cardiovascular Medicine


Whitaker Cardiovascular Institute

Evans Center for Interdisciplinary Biomedical Research


Alice K. Jacobs, MD, FACC, FAHA, MSCAI is a Professor of Medicine at Boston University School of Medicine and served as the Director of the Cardiac Catheterization Laboratories and Interventional Cardiology for 20 years until 2011. She is currently Vice Chair for Clinical Affairs in the Department of Medicine at Boston University Medical Center and maintains an active clinical practice. Dr. Jacobs has led the American Heart Association’s Mission: Lifeline, a community-based, national initiative to develop systems of care for ST-segment elevation myocardial infarction (STEMI) patients and to increase the number of patients with timely access to primary percutaneous coronary intervention. Mission: Lifeline has now expanded to include Out-of-Hospital Cardiac Arrest and Stroke systems of care. Dr. Jacobs served as president of the American Heart Association in 2004-05 and as president of the Association of University Cardiologists in 2011. She is a past chair of the ACC/AHA Task Force on Practice Guidelines. During her tenure, the guidelines process and methodology evolved to include formal systematic evidence reviews, inclusion of patient representatives and lay members on guideline committees, incorporation of an Evidence Grading Tool, and further enhancements to the Class of Recommendation/Level of Evidence schema. Dr. Jacobs is a prior member of CMS MEDCAC and the IOM Committee on Social Security Cardiovascular Disability. Currently, she is the immediate past-chair of the American Board of Internal Medicine Interventional Cardiology Self-Assessment Test Committee, a member of NHLBI Cardiothoracic Surgical Network Protocol Review Committee and a member of the New York State Cardiac Advisory Committee. Her major research interest is in coronary revascularization strategies and sex-based difference in ischemic heart disease.

Expertise includes: Interventional Cardiology; Coronary revascularization; Sex-based differences in cardiovascular disease.


Medicine, MD, Saint Louis University, 1975

Biology, BA, State University of New York at Buffalo, 1971


Published on 3/28/2021

Hannan EL, Wu YF, Cozzens K, Tamis-Holland J, Ling FSK, Jacobs AK, Venditti FJ, Berger PB, Walford G, King Iii SB. Hybrid coronary revascularization vs. percutaneous coronary interventions for multivessel coronary artery disease. J Geriatr Cardiol. 2021 Mar 28; 18(3):159-167. PMID: 33907545.

Published on 12/8/2020

Hannan EL, Wu Y, Cozzens K, Friedrich M, Tamis-Holland J, Jacobs AK, Ling FSK, King SB, Venditti FJ, Walford G, Berger PB, Kirtane AJ, Kamran M. Percutaneous Coronary Intervention for ST-Elevation Myocardial Infarction Before and During COVID in New York. Am J Cardiol. 2021 03 01; 142:25-34. PMID: 33301770.

Published on 11/7/2020

Shahandeh N, Dai X, Jaski B, Dave R, Jacobs A, Denktas A, Levine G, Markovic D, Smith SC, Press MC. Mortality differences among patients with in-hospital ST-elevation myocardial infarction. Clin Cardiol. 2020 Dec; 43(12):1555-1561. PMID: 33159461.

Published on 7/1/2020

Mendirichaga R, Jacobs AK. Sex Differences in Ischemic Heart Disease-the Paradox Persists. JAMA Cardiol. 2020 07 01; 5(7):754-756. PMID: 32227138.

Published on 4/22/2020

Al-Lamee R, Jacobs AK. ISCHEMIA Trial: Was It Worth the Wait? Circulation. 2020 08 11; 142(6):517-519. PMID: 32316761.

Published on 1/20/2020

Kontos MC, Gunderson MR, Zegre-Hemsey JK, Lange DC, French WJ, Henry TD, McCarthy JJ, Corbett C, Jacobs AK, Jollis JG, Manoukian SV, Suter RE, Travis DT, Garvey JL. Prehospital Activation of Hospital Resources (PreAct) ST-Segment-Elevation Myocardial Infarction (STEMI): A Standardized Approach to Prehospital Activation and Direct to the Catheterization Laboratory for STEMI Recommendations From the American Heart Association's Mission: Lifeline Program. J Am Heart Assoc. 2020 01 21; 9(2):e011963. PMID: 31957530.

Published on 10/23/2019

Hannan EL, Zhong Y, Ling FSK, Tamis-Holland J, Berger PB, Jacobs AK, Walford G, Venditti FJ, King SB. Assessment of repeat target lesion percutaneous coronary intervention as a quality measure for public reporting and general quality assessment for PCIs. Catheter Cardiovasc Interv. 2020 10 01; 96(4):731-740. PMID: 31642597.

Published on 5/1/2019

Rymer JA, Kaltenbach LA, Kochar A, Hess CN, Gilchrist IC, Messenger JC, Harrington RA, Jolly SS, Jacobs AK, Abbott JD, Wojdyla DM, Krucoff MW, Rao SV. Comparison of Rates of Bleeding and Vascular Complications Before, During, and After Trial Enrollment in the SAFE-PCI Trial for Women. Circ Cardiovasc Interv. 2019 05; 12(5):e007086. PMID: 31014090.

Published on 4/22/2019

Hannan EL, Wu Y, Tamis-Holland J, Jacobs AK, Berger PB, Ling FSK, Walford G, Venditti FJ, King SB. Sex differences in the treatment and outcomes of patients hospitalized with ST-elevation myocardial infarction. Catheter Cardiovasc Interv. 2020 02; 95(2):196-204. PMID: 31012227.

Published on 2/19/2019

Pande AN, Jacobs AK. Reperfusion and Time to Presentation in Women: Too Little Too Late. J Am Heart Assoc. 2019 02 19; 8(4):e011835. PMID: 30767600.

View full list of 405 publications.