2020 Evans Day Poster Session Schedule

Session A – Channel 1 Thursday 11/5 8:30-10:00 am

56 LIVER ACTIVITY MODULATES THE LUNG TO FORTIFY PULMONARY DEFENSE

Christine Odom, Yuri Kim, Filiz Korkmaz, Elim Na, Lillia Baird, Matthew Jones, Joseph Mizgerd, Katrina Traber, Lee Quinton.

166 DERIVATION OF PUTATIVE MOUSE AIRWAY BASAL STEM CELLS FROM MOUSE PLURIPOTENT STEM CELLS

Liang Ma, Michael Herriges, Darrell Kotton.

44 BCL11B REGULATES AORTIC STIFFNESS BY REGULATING VASCULAR SMOOTH MUSCLE CONTRACTILE PHENOTYPEBCL11B REGULATES AORTIC STIFFNESS BY REGULATING VASCULAR SMOOTH MUSCLE CONTRACTILE PHENOTYPE

Jeff Arni Valisno, Joel May, Kuldeep Singh, Lisia Venegas, Enkhjargal Budbazar, Eric Helm, Christopher Nicholson, Dorina Avram, Richard Cohen, Kathleen Morgan, Francesca Seta.

36 NOTCH ACTIVATION DURING MESODERM INDUCTION MODULATES EMERGENCE OF THE T/NK CELL LINEAGE FROM HUMAN IPSCS

Dar Heinze, Seonmi Park, Mona Haratianfar, Carlos Villacorta-Martin, Aditya Mithal, Andrew McCracken, Gustavo Mostoslavsky.

144 TRANSPLANTATION OF MOUSE PLURIPOTENT STEM CELL DERIVED DISTAL TIP-LIKE CELLS INTO IMMUNOCOMPETENT MICE

Michael Herriges, Carlos Villacorta-Martin, Darrell Kotton.

157 INDOXYL SULFATE EXPLOITS THE TMIGD1-C/EBPΒ AXIS TO COMPROMISE THE RENAL TUBULE CELLS SURVIVAL

John Le, Wenqing yin, Marc Napoleon, Sean Richerds, Mostafa Belghasem, Nader Rahimi, Dominic Lo, saran Lotfollahzadeh, Vipul Chitalia.

46 ENHANCED PREDICTION AND DECONVOLUTION OF MUTATIONAL SIGNATURES

Aaron Chevalier, Shiyi Yang, Masanao Yajima, Joshua Campbell.

163 ;Δ T CELL DYSREGULATION ACCOMPANIES HISTOLOGICAL PROGRESSION OF DYSPLASTIC LESIONS IN A MURINE MODEL OF LUNG SQUAMOUS CELL CARCINOMA

Táchira Pichardo, Riley Pihl, Darren Chiu, Anna Belkina, Jennifer Beane, Jennifer Snyder-Cappione, Sarah Mazzilli.

148 ROLE OF VASCULAR SMOOTH MUSCLE SIRTUIN-1 IN AORTIC ANEURYSM

Yuhao Huangfu, Francesca Seta.

49 DISSECTING RESISTANCE TO AGING-RELATED DISEASE

Todd Dowrey, Tanya Karagiannis, Carlos Villacorta Martin, Paola Sebastiani, Stefano Monti, Thomas Perls, George Murphy.

Session B – Channel 1 Thursday 11/5 10:30 am-12:00 pm

59 EFFECTS OF SGLT2 INHIBITION WITH ERTUGLIFLOZIN ON MYOCARDIAL REMODELING, ENERGETICS, AND GENE EXPRESSION IN THE PRESENCE AND ABSENCE OF DIABETES IN MICE

Dominique Croteau, Ivan Luptak, Jordan Chambers, Ion Hobai, Marcello Panagia, David Pimentel, Deborah Siwik, Fuzhong Qin, Wilson Colucci.

170  LUNG MESENCHYMAL CELL RESPONSES TO PNEUMONIA

Alicia Soucy, Joshua Campbell, Tianmu Hu, Ian Martin, Joseph Mizgerd.

10 LUNG MEGAKARYOCYTES DISPLAY DISTINCT TRANSCRIPTIONAL AND PHENOTYPIC PROPERTIES

Anthony Yeung, Carlos Villacorta-Martin, Stephanie Hon, Jason Rock, George Murphy.

45 LIVER REPAIR VIA TRANSIENT ACTIVATION OF REGENERATIVE PATHWAYS IN HEPATOCYTES USING LIPID NANOPARTICLE- COMPLEXED NUCLEOSIDE- MODIFIED MRNA

Anna Smith, Fatima Rizvi, Elissa Everton, Hua Liu, Elizabeth Osota, Mitchell Beattie, Ying Tam, Norbert Pardi, Drew Weissman, Valerie Gouon-Evans.

165 GLUTAREDOXIN-1 PREVENTS ALCOHOL-INDUCED VASCULAR DYSFUNCTION

Kerstin Seidel, Jingyan Han.

158 DERIVATION OF A LUNG CANCER CLASSIFIER USING NASAL GENE EXPRESSION AND RADIOMICS IN PATIENTS WITH INDETERMINATE PULMONARY NODULES (DECAMP-1) STUDY

Robert Smyth, Xu Ke, Raul Estepar, Ruben Estepar, George Washko, Ehab Bilatos, Avrum Spira, Marc Lenburg.

51 REGULATORY NETWORK RECONSTRUCTION AND COMPARISON TO MODEL CHEMICAL PERTURBATIONS

Anthony Federico, Stefano Monti.

169 MODELING THE TRANSCRIPTOMIC AND EPIGENETIC LANDSCAPE OF LUNG SPECIFICATION

Taylor Matte, Jake Le Suer, Andrew Berical, Mary Lou Beerman, Carlos Villacorta Martin, Michael Herriges, Nicole Ranallo, Finn Hawkins.

150 A NOVEL ANIMAL MODEL OF CENTRAL VENOUS STENOSIS

Dominic Lo, Saran Lotfollahzadeh, John Le, Vipul Chitalia.

41 PULMONARY TUBERCULOSIS DISEASE CO-INFECTION IS ASSOCIATED WITH INCREASED ANTI-HIV-1 B CELL IMMUNITY

Bukola Adeoye.

Session C – Channel 2 Thursday 11/5 8:30-10:00 am

125 NSCLC SUBTYPE-ASSOCIATED MOLECULAR AND CELLULAR ALTERATIONS IN THE NORMAL-APPEARING BRONCHIAL EPITHELIUM

Xingyi Shi, Jiarui Zhang, Steven Callori, Denise Fine, Gang Liu, Sherry Xiao, Avrum Spira, Joshua Campbell, Marc Lenburg, Jennifer Beane.

177 ANTIBODY-DEPENDENT CELLULAR CYTOTOXICITY (ADCC) AS A CORRELATE OF PROTECTION (COP) IN MOTHER-TO-CHILD- TRANSMISSION OF HIV-1

Allison Thomas, Yvetane Moreau, Manish Sagar.

54 DEEP LEARNING DRIVEN ASSESSMENT OF INFLAMMATORY REGIONS IN DIGITIZED KIDNEY BIOPSIES

Christopher Lin.

117 GLUTAREDOXIN 1 PROTECTS PRIMARY HUMAN AORTIC ENDOTHELIAL CELLS FROM APOPTOSIS: ROLE OF GAPDH GLUTATHIONYLATION

Syed Husain Mustafa Rizvi, Shao Di, Erika Minetti Teresa, David Pimental, Robert Weisbrod, Naomi Hamburg, Reiko Matsui, Markus Bachschmid.

171 TRANSCRIPTIONAL CROSSTALK BETWEEN YAP, TEAD AND TP63 IS ASSOCIATED WITH EARLY LUNG CARCINOGENESIS

Boting Ning, Andrew Tilston-Lunel, Julia Hicks-Berthet, Sarah Mazzilli, Xaralabos Varelas, Jennifer Beane-Ebel, Marc Lenburg.

162 A DEEP LEARNING APPROACH FOR SEMANTIC SEGMENTATION OF EPITHELIAL REGIONS FROM AN ENDOBRONCHIAL BIOPSIES Saranyaraj Devaraj, Divya Lakshmi Venkatraman, Jing Yu, Emily Green, Sarah Mazzilli, Eric Burks, Vijaya B. Kolachalama, Jennifer Beane.

61 BI-CLUSTERING OF TRANSCRIPTIONAL STATES AND CELLULAR POPULATIONS IN DISCRETE SINGLE-CELL RNA-SEQ DATA

Zhe Wang, Yusuke Koga, Shiyi Yang, Masanao Yajima, Joshua Campbell.

174 STUDY OF SEXUAL DIMORPHISM ON ISCHEMIC VASCULARIZATION IN MIDDLE AGED MICE

Beatriz Ferran Perez, Erika Minetti, Yuko Tsukahara, Reiko Matsui.

151 COCAINE WITHDRAWAL-INDUCED MIRNA TRANSCRIPTOMIC CHANGES IN RAT BRAIN REWARD REGIONS

Vidhya Kumaresan, Yolpanhchana Lim, Olivier George, Lindsay Farrer, David Henderson, Huiping Zhang.

65 DISTINCT IMPACT OF AGING AND HYPERLIPIDEMIA ON UNFOLDED PROTEIN RESPONSE IN MOUSE MODEL OF ATHEROSCLEROSIS

Yuxiang Zhou, Li Bin, Xueping Wan, Kerstin Seidel, Zhaoyuan Li, Jingyan Han.

Session D – Channel 2 Thursday 11/5 10:30 am-12:00 pm

130 MODELING CREUTZFELDT-JAKOB DISEASE USING HUMAN IPSC- DERIVED NEURONS

Aldana Gojanovich, Nhat Le, Robert Mercer, David Harris, Gustavo Mostoslavsky.

179 GLUTAREDOXIN-1 ATTENUATES AGE-INDUCED LIVER FIBROSIS BY INHIBITING HEPATOCYTES APOPTOSIS

1. Tsukahara, B. Ferran, E. Minetti, B. Chong, M. Bachschmid, R. Matsui.

127 HORMONE THERAPY TO ACCELERATE REGENERATION FROM SEXUALLY DIMORPHIC ACETAMINOPHEN-INDUCED LIVER INJURY

Elissa Everton, Carlos Villacorta-Martin, Fatima Rizvi, Valerie Gouon-Evans.

121 INDOLIC SOLUTE IS A CKD-SPECIFIC SUPPRESSOR OF WNT SIGNALING AND A PROMOTER OF PERIPHERAL ARTERY

Wenqing Yin, Nkiruka Arinze, Saran Lotfollahzadeh, Marc Napoleon, Naomi Hamburg, Nader Rahimi, Vipul Chitalia.

57 SMOKING DIFFERENTIALLY MODULATES SARS-COV-2 ENTRY GENE EXPRESSION IN THE NOSE AND BRONCHUS

Chris Husted, Ke Xu, Xingyi Shi, Boting Ning, Avrum Spira, Sarah Mazzilli, Ehab Billatos, Marc Lenburg, Joshua Campbell, Jennifer Beane.

167 MALNUTRITION IS ASSOCIATED WITH INCREASED INFLAMMATION AND INCREASED TUBERCULOSIS RISK SIGNATURES IN INDIVIDUALS WITH LATENT MYCOBACTERIUM TUBERCULOSIS INFECTION

Arthur VanValkenburg, Vaishnavi Kaipilyawar, Sonali Sarkar, William Evan Johnson, Padmini Salgame, Natasha Hochberg, JIPMER-RePORT India Consortium India Consortium.

115 CHARACTERIZING DISTINCT POPULATIONS OF AATD PATIENT- SPECIFIC IHEPS USING SCRNA SEQ

Joseph Kaserman, Carlos Villacorta-Martin, Darrell Kotton, Andrew Wilson.

178 THE ROLE OF REVERSIBLE OXIDATION OF SIRT1 IN AORTIC ANEURYSM IN MARFAN’S SYNDROME

Enkhjargal Budbazar, Yuhao Huangfu, Francesca Seta.

173 ADDRESSING THE EXAGGERATED SIGNIFICANCE PROBLEM IN BATCH EFFECT ADJUSTMENTS

Tenglong Li.

119 DELETION OF THE MITOCHONDRIAL ABCB10 ALTERS NUCLEAR GENE EXPRESSION

Jordan Chambers, Dominique Croteau, David Pimentel, Ivan Luptak, Marc Liesa, Orian Shirihai, Deborah Siwik, Wilson Colucci.

Session E – Channel 3 Thursday 11/5 8:30-10:00 am

138 PATIENT-SPECIFIC IPSCS CARRYING AN SFTPC MUTATION REVEAL THE INTRINSIC ALVEOLAR EPITHELIAL DYSFUNCTION AT THE INCEPTION OF INTERSTITIAL LUNG DISEASE

Konstantinos Alysandratos, Scott Russo, Anton Petcherski, Evan Taddeo, Rebeca Acín-Pérez, J. C. Jean, Marall Vedaie, Carlos Villacorta-Martin, Benjamin Blum, Ryan Hekman, Surafel Mulugeta, Andrew Emili, Orian Shirihai, Michael Beers, Darrell Kotton.

182 AN IPS CELL-BASED MODEL TO STUDY LUNG MESENCHYME DEVELOPMENT AND DISEASE

Andrea Alber, Hector Marquez, Laertis Ikonomou, Darrell Kotton.

128 UTILIZING THE IPSC DIRECTED DIFFERENTIATION PLATFORM TO IDENTIFY STAGE DEPENDENT ROLES OF WNT AND RETINOIC ACID SIGNALING IN LUNG PROGENITOR SPECIFICATION

Jake Le Suer, Taylor Matte, Mary Lou Beerman, Nicole Ranallo, Finn Hawkins.

122 DEVELOPMENT OF AN IPSC-BASED TOOLBOX FOR THE STUDY OF CYSTIC FIBROSIS

Andrew Berical, Mary Beermann, Rhianna Lee, Scott Randell, Darrell Kotton, Finn Hawkins.

145 AIRWAY-ASSOCIATED MYELOID CELLS IN HOMEOSTASIS AND REPAIR

Anna Engler, Alexandra Ysasi, Carlos Villacorta-Martin, Riley Pihl, Sarah Mazzilli, Anna Belkina, Jason Rock.

172 GENERATION OF HUMAN ALVEOLAR EPITHELIAL TYPE I CELLS FROM PLURIPOTENT STEM CELLS

Claire Burgess, Darrell Kotton.

120 THE DEVELOPMENT OF A QUALITY CONTROL PIPELINE FOR SINGLE- CELL RNA-SEQ DATA

Anastasia Leshchyk, Shruthi Bandyadka, Yusuke Koga, Rui Hong, Zhe Wang, Joshua Campbell, W. Evan Johnson, Masanao Yajima.

190 MOLECULAR MECHANISMS INFLUENCING BASAL CELL FATE

Adeline Matschulat.

11 GSTP1 AS A MEDIATOR OF IMMUNE RESPONSE IN BRONCHIAL PREMALIGNANT LESIONS

Julia Breda, Carter Merenstein, Christopher Stevenson, Mary Reid, Avrum Spira, Marc Lenburg, Sarah Mazzilli, Jennifer Beane, Eric Burks.

141 NOTCH SIGNALING IN PROLIFERATION AND DIFFERENTIATION OF ALVEOLAR EPITHELIAL TYPE 2 CELLS IN INJURY REPAIR

Bibek Thapa, Jason Rock, Darrell Kotton.

Session F – Channel 3 Thursday 11/5 10:30 am-12:00 pm

155 A COMPREHENSIVE INDUCED PLURIPOTENT STEM CELL-BASED MODEL OF CROHN’S DISEASE

Aditya Mithal, Marianne James, Aine Russell, Francis Farraye, Gustavo Mostoslavsky.

185 SINGLE CELL RNA SEQUENCING REVEALS NOVEL MECHANISM OF KIDNEY FIBROSIS IN ZEB2 KNOCK OUT MICE

Rhianna DelBene, Weining Lu, Sudhir Kumar.

140 THROMBIN- PROTEASE-ACTIVATED RECEPTORS (PAR)-1/2 SIGNALING AXIS AUGMENTS DS-RNA VIRAL MIMETIC-DRIVEN PROCOAGULATION AND PROINFLAMMATORY RESPONSES IN HUMAN VASCULAR ENDOTHELIAL CELLS

Saravanan Subramaniam, Yamini Ogoti, Irene Hernandez, Mark Zogg, Robert Burns, Hartmut Weiler.

124 TRANSCRIPTIONAL, PROTEIN-LEVEL AND FUNCTIONAL PROFILING OF FETAL LIVER-DERIVED HEMATOPOIETIC STEM CELLS AT SINGLE CELL RESOLUTION

Kim Vanuytsel, Carlos Villacorta Martin, Jonathan Lindstrom-Vautrin, Zhe Wang, Wilfredo Garcia Beltran, Taylor Matte, Todd Dowrey, Sara Kumar, Vanessa Mengze Li, Joshua Campbell, Anna Belkina, Alejandro Balazs, George Murphy.

42 SARS-COV-2 INFECTION OF PLURIPOTENT STEM CELL-DERIVED HUMAN LUNG ALVEOLAR TYPE 2 CELLS ELICITS A RAPID EPITHELIAL-INTRINSIC INFLAMMATORY RESPONSE

Jessie Huang, Adam Hume, Kristine Abo, Rhiannon Werder, Carlos Villacorta- Martin, Konstantinos-Dionysios Alysandratos, Mary Lou Beermann, Chantelle Simone-Roach, Judith Olejnik, Ellen Suder, Esther Bullitt, Anne Hinds, Arjun Sharma, Markus Bosmann, Ruobing Wang, Finn Hawkins, Eric Burks, Mohsan Saeed, Andrew Wilson, Elke Mühlberger, Darrell Kotton.

176 THE PULMONARY LYMPHATIC SYSTEM’S RESPONSE TO INFLUENZA INFECTION

Senegal Carty, Alexandra Ysasi, Michelle Zeng, Alan Fine, Matthew Jones.

123 LIF-DEPENDENT REGULATION OF APOPTOSIS IN THE PNEUMONIC LUNG

Elim Na, Filiz Korkmaz, Christine Odom, Lillia Baird, Matthew Jones, Joseph Mizgerd, Katrina Traber, Lee Quinton.

12 SIGREPO: A STRUCTURED PLATFORM FOR THE STORAGE AND STREAMLINED ANALYSIS OF MULTI-OMICS SIGNATURES Callen

Bragdon, Mengze Li, Rebekah Miller, Stefano Monti.

197 CROSS-SECTIONAL ANALYSIS IDENTIFIES CELLULAR AND MOLECULAR PATTERNS ASSOCIATED WITH BRONCHIAL PRE- MALIGNANCY AND EARLY CARCINOMA

Conor Shea, Diane Ding, Sherry Zhang, Gang Liu, Kitty De Jong, Lukas Kalinke, Kate Gowers, Mary Reid, Mark Hennon, Sai Yendumuri, Samuel Janes, Sarah Mazzilli, Jennifer Beane, Marc Lenburg, Avrum Spira, Joshua Campbell.

154 TFEB DYNAMICS DURING PNEUMONIA

Lillia Baird, Katrina Traber, Joseph Moreau, Javier Irazoqui, Lee Quinton.

Session G – Channel 1 Friday 11/6 8:30-10:00 am

161 TARGETED DIETARY INTERVENTION TO ABROGATE A POTENT UREMIC TOXIN

Marc Napoleon.

196 MICROBIAL DYSBIOSIS AND EPITHELIAL BARRIER DYSFUNCTION IN VITAMIN A-DEFICIENT LUNGS

Kiloni Quiles, Felicia Chen MD, Evan Johnson PhD.

143 GENE EXPRESSION ALTERATIONS REVEAL MOLECULAR AND CELLULAR EVENTS IN SMOKERS WITH RADIOGRAPHIC BRONCHIECTASIS

Ke Xu, Alejandro Diaz, Avrum Spira, Ehab Billatos, Marc Lenburg.

132 LUNG EPITHELIAL CELLS EXHIBIT ANATOMICALLY SEGREGATED AND TEMPORALLY DYNAMIC ABILITIES TO INTERACT WITH CD4+ T CELLS

Anukul Shenoy, Emad Arafa, Carolina Lyon De Ana, Kimberly Barker, Filiz Korkmaz, Aditya Ramanujan, Ian Martin, Jason Rock, Matthew Jones, Anna Belkina, Lee Quinton, Joseph Mizgerd.

192 NASOPHARYNGEAL DYSBIOSIS PRECEDES SYMPTOMS IN INFANTS WITH SEVERE RESPIRATORY TRACT INFECTIONS

Tyler Faits.

181 INTERACTIVE ANALYSIS OF SINGLE CELL TRANSCRIPTOMICS DATA WITH SCTK2.0

Salam AlAbdullatif, Yusuke Koga, Yichen Wang, Rui Hong, Zhe Wang, Joshua Campbell.

133 POTENTIAL ROLE OF GROUP 2 INNATE LYMPHOID CELLS IN PROXIMAL AIRWAY EPITHELIAL REPAIR

Alex Ysasi, Anna Engler, Carlos Villacorta-Martin, Hailey Heston, Joseph Mizgerd, George Murphy, Jason Rock.

17 THE TBSIGNATUREPROFILER: A NOVEL R PACKAGE FOR COMPARING TUBERCULOSIS GENE EXPRESSION SIGNATURES

Aubrey Odom, W. Evan Johnson.

129 FLI1 DEFICIENT MYELOID CELLS INDUCE PERIOSTIN AND GALECTIN-3 EXPRESSION AND HAVE PROFIBROTIC EFFECTS

Fatima-EZ-Zahrae El adili.

156 GLUTAREDOXIN-1, A THIOL REDOX SIGNALING MODULATOR IS DOWNREGULATED BY CARDIOVASCULAR RISK FACTORS

xueping Wan, Jingyan Han.

Session H – Channel 1 Friday 11/6 10:30 am-12:00 pm

193 HUMAN IPSC-DERIVED ALVEOLAR TYPE 2-LIKE CELLS MATURE AT AIR-LIQUID INTERFACE AND ARE SUSCEPTIBLE TO SARS-COV-2 INFECTION

Kristine Abo, Jessie Huang, Rhiannon Werder, Adam Hume, Konstantinos Alysandratos, Carlos Villacorta-Martin, Elke Muhlberger, Darrell Kotton, Andrew Wilson.

153 REPURPOSING CRISPR/CAS9 FOR TARGETED CHROMATINIZATION OF HIV PROVIRUS AS BLOCK-AND-LOCK APPROACH TO CURE

Alex Olson, Binita Basukala, Seunghee Lee, Matthew Gagne, Wilson Wong, Andrew Henderson.

135 INVESTIGATING THE ROLE OF FAM13A IN IPS-DERIVED LUNG EPITHELIAL CELLS

Rhiannon Werder, Michael Cho, Xiaobo Zhou, Darrell Kotton, Andrew Wilson.

200 ELUCIDATING THE EFFECTS OF STATINS ON PANCREATIC Β-CELL METABOLISM AND FUNCTION

James Hamilton.

183 LOX-1 IS DIFFERENTIALLY EXPRESSED ON LUNG CELLS AND LIMITS INFLAMMATORY INJURY DURING PNEUMONIA

Filiz Korkmaz, Elise Symer, Anukul Shenoy, Lillia Baird, Christine Odom, Emad Arafa, Elim Na, Ernest Dimbo, Theodore Standiford, Matthew Jones, Joseph Mizgerd, Katrina Traber, Lee Quinton.

139 T-CELL LANDSCAPE OF HETEROTYPIC IMMUNE LUNGS

Carolina Lyon De Ana, Anukul Shenoy, Kimberly Barker, Emad Arafa, Anna Belkina, Joseph Mizgerd.

35 NEUROANATOMICAL LOCALIZATION AND CO-LOCALIZATION OF GΑI2 EXPRESSING HYPOTHALAMIC PARAVENTRICULAR NUCLEUS NEURONS

Parul Chaudhary, Richard Wainford.

 142 INVESTIGATION OF EFFECTS OF OPIOIDS ON HIV REPLICATION IN PRIMARY CD4 T CELLS

Binita Basukala, John Cleary, Christine Cheng, Andrew Henderson.

159 IMMUNE PHENOTYPING OF LUNG ADENOCARCINOMA SAMPLES USING IMAGING MASS CYTOMETRY

ZhanHao Xi, Roxana Pfefferkorn, Eric Burks, Jennifer Beane, Sarah Mazzilli.

62 OPTICAL COHERENCE TOMOGRAPHY-BASED FUNCTIONAL IMAGING OF MURINE FEMORAL ARTERY: A NEW APPROACH TO ASSESSMENT OF VASCULAR ENDOTHELIAL FUNCTION IN MOUSE MODEL.

Mo Zhang.

Session I – Channel 2 Friday 11/6 8:30-10:00 am

43 LANGUAGE BARRIERS AND ICU OUTCOMES DURING THE COVID-19 PANDEMIC

Nathan Mesfin, Shelsey Johnson, Michael Garcia, Alexandra Fischman, Michael Ieong.

33 FROM BUS PASS TO RECOVERY CLASS: A PEER MENTOR’S ROLE IN WELLNESS AS PART OF AN INPATIENT ADDICTION CONSULT SERVICE

Sarika Gurnani, Yoel Benarroch, Theresa Rolley, Zoe Weinstein.

188 ALPHA-1 ANTITRYPSIN DEFICIENCY ADULT CLINICAL AND GENETIC LINKAGE STUDY

Mark Dodge, Michelle Higgins, Nora Lee, Erica Meninno, Grace (Qing) Zhao, Joseph Kaserman, Andrew Wilson.

58 RESULTS FROM A SURVEY OF BOSTON MEDICAL CENTER SUB- SPECIALTY FELLOWS ON PERCEIVED PREPAREDNESS AND TRAINING FOR MANAGING AFTER-HOURS PAGES

Niyoti Reddy, Pooja Bhargava, Katherine Modzelewski, Sara Alexanian.

195 RISK FACTORS FOR ACUTE KIDNEY INJURY DURING AUTOLOGOUS STEM CELL TRANSPLANTATION IN AL AMYLOIDOSIS

Ralph Nader, Stephanie Pavlovich, Avital Angel-Korman, Aileen Zhen, Alexander Pogrebinsky, Gheorghe Doros, Hanni Menn-Josephy, Lauren Stern, Shayna Sarosiek, Dina Brauneis, Vaishali Sanchorawala, Andrea Havasi.

22 I WAS TAKING THE SUBOXONE EVEN THOUGH I HATED IT⋯: A QUALITATIVE EXPLORATION OF STIGMA AND EXPERIENCES RELATED TO TAKING MEDICATIONS FOR OPIOID USE DISORDERS AMONG YOUNG ADULTS

Sarah Bagley, Samantha Schoenberger, Scott Hadland, George Massey, Vanessa dellaBitta, Ted Park.

147 ADHERENCE TO LUNG-RADS RECOMMENDATIONS IN A NATIONAL COHORT OF US VETERANS SCREENED FOR LUNG CANCER, 2015-2019

Eduardo Nunez, Tanner Caverly, Shirley Qian, Jacqueline Boudreau, Christopher Slatore, Sanqian Zhang, Mark Glickman, Donald Miller, Renda Wiener.

189 COVID-19 IN HOSPITALIZED PATIENTS WITH END-STAGE KIDNEY DISEASE: EXPERIENCE FROM BOSTON MEDICAL CENTER

Hassan Mahmoud, Mohamed Hassan-Kamel, Aileen Zhen, Jing Liu, Titilayo Ilori, Sushrut Waikar, Ashish Upadhyay.

66 INCREASED MORTALITY AMONG AFRICAN AMERICAN PATIENTS WITH HEART FAILURE CAUSED BY HEREDITARY V122I TRANSTHYRETIN AMYLOID CARDIOMYOPATHY (HATTR-CM)

Meena Zareh, Alina Levine, John Berk, Omar Siddiqi, Deepa Gopal, Lawreen Connors, Denise Fine, Codruta Chiuzan, Mathew Maurer, Frederick Ruberg.

73 TROPONIN I LEVELS DURING SEPSIS AND CARDIOVASCULAR COMPLICATIONS FOLLOWING DISCHARGE FROM SEPSIS HOSPITALIZATION

Michael Garcia, Justin Rucci, Khanh Thai, Yun Lu, Patricia Kipnis, Alan Go, Manisha Desai, Nicholas Bosch, Adriana Martinez, Heather Clancy, Ycar Devis, Vincent Liu, Allan Walkey.

Session J – Channel 2 Friday 11/6 10:30 am-12:00 pm

186 TB OR NOT TB? THAT IS THE QUESTION: INCIDENTAL FINDINGS IN A PATIENT WITH BACK PAIN

Kantiya Jindachomthong, Charles Milrod, Michael Mann, Thomas Ostrander.

160 GUIDELINE COMPLIANCE AND OUTCOMES OF THE DIAGNOSIS AND MANAGEMENT OF THYROID CANCER AT BOSTON MEDICAL CENTER

Danica Vodopivec Kuri, Nipith Charoenngam, Stephanie Lee.

16 CDH11, SMOC2, AND PEDF ARE PROMISING NON-INVASIVE BIOMARKERS OF KIDNEY FIBROSIS

Insa Schmidt.

137 ENHANCING MR IMAGING DRIVEN ALZHEIMER’S DISEASE CLASSIFICATION PERFORMANCE USING GENERATIVE ADVERSARIAL LEARNING

Xiao Zhou, Shangran Qiu, Prajakta Joshi, Chonghua Xue, Ronald Killiany, Asim Mian, Peter Chin, Rhoda Au, Vijaya Kolachalama.

7       CARDIAC CONDUCTION SYSTEM ABNORMALITIES IN SYSTEMIC SCLEROSIS RELATED-PULMONARY HYPERTENSION

Justin Lui, Ruchika Sangani, Clara Chen, Andreea Bujor, Marcin Trojanowski, Deepa Gopal, Renda Wiener, Elizabeth Klings.

64 LIFETIME RISK OF HEART FAILURE IN PATIENTS WITH TYPE 2 DIABETES

Brian Schwartz, Asya Lyass, Christian Torp-Pedersen, Vasan Ramachandran, Morten Schou, Gunnar Gislason, Lars Koeber, Charlotte Andersson.

184 ARTERIAL STIFFNESS LEADS TO INCREASED INCIDENT OF CEREBRAL MICROBLEEDS

Lisia Venegas, Joel May, Sabreea Parnell, Jeff Arni Valisno, Erika Minetti, Francesca Seta.

32 RACIAL DISPARITIES IN DIABETES TECHNOLOGY USE AND OUTCOMES IN TYPE 1 DIABETES IN A SAFETY-NET HOSPITAL

Kathryn Fantasia, Kamonkiat Wirunsawanya, Christopher Lee, Ivania Rizo.

175 CO-SEGMENTATION OF GLOMERULI ON HISTOLOGICAL IMAGES FROM MULTIPLE STAINS USING DEEP LEARNING

Divya Veerapaneni, Yichi Zhang.

40 RACIAL DISPARITIES IN EARLY- AND LATE-ONSET COLORECTAL CANCER INCIDENCE, 2001-2016

Jessica Petrick, Lauren Barber, Shaneda Warren Andersen, Andrea Florio, Julie Palmer, Lynn Rosenberg.

Session K – Channel 3 Friday 11/6 8:30-10:00 am

60 IMPACT OF A HEME/ONC INPATIENT HANDBOOK ON RESIDENT SATISFACTION

Lindsey Hildebrand, Jose Acevedo, Naomi Ko.

55 A QUALITATIVE STUDY OF HIV-POSITIVE PATIENTS’ NAVIGATION OF ADDICTION CARE IN SAINT PETERSBURG, RUSSIA

Marina Vetrova, Olga Toussova, Elena Blokhina, Natalia Bushara, Bulat Idrizov, Sally Bendiks, Sarah Rossi, Jeffrey Samet, Evgeny Krupitsky, Dmitry Lioznov, Karsten Lunze.

8       DESCRIBING THE PARADOXICAL ASSOCIATION OF THE CARDIOVASCULAR HEALTH SCORE WITH SUBCLINICAL AND CLINICAL CARDIOVASCULAR DISEASEIN THE FRAMINGHAM HEART STUDY

Maximillian Bourdillon, Rebecca Song, Ramachandran Vasan, Vanessa Xanthakis.

116 MID TO LATE LIFE HYPERTENSION TRENDS AND CEREBRAL SMALL VESSEL DISEASE IN THE FRAMINGHAM HEART STUDY

Rodica Petrea, Adrienne O’Donnell, Alexa Beiser, Mohammad Habes, Hugo Aparicio, Charles DeCarli, Sudha Seshadri, Jose Rafael Romero.

201 PEER MENTOR SUPPORT AND HEALTHCARE OUTCOMES

Yoel Benarroch, Sarika Gurnani, Leah Forman, Theresa Rolley, Zoe Weinstein.

52 PLEIOTROPY ANALYSIS OF CHRONIC TRAUMATIC ENCEPHALOPATHY WITH OTHER TAUOPATHIES INCLUDING PROGRESSIVE SUPRANUCLEAR PALSY AND ALZHEIMER’S DISEASE

Mohammed Muzamil Khan.

149 DEVELOPING A NOVEL TECHNIQUE TO QUANTIFY & PREDICT KIDNEY FIBROSIS:

Saran Lotfollahzadeh.

131 COMPARATIVE EFFECTIVENESS OF MEDICATIONS USED FOR HEART RATE CONTROL IN ATRIAL FIBRILLATION DURING SEPSIS

Justin Rucci, Nicholas Bosch, Joseph Massaro, Michael Winter, Emily Quinn, Ki Chon, David McManus, Allan Walkey.

136 A QUALITY IMPROVEMENT INITIATIVE TO REDUCE HYPOGLYCEMIA DURING TREATMENT OF HYPERGLYCEMIC CRISES

Katherine Modzelewski, Ariana Cannavo, Kathryn Fantasia, Sira Korpaisarn, Sara Alexanian.

48 HARM REDUCTION CURRICULUM FOR MEDICAL TRAINEES- A NEED FOR HOLISTIC ADDICTION MEDICAL EDUCATION

Raagini Jawa, Nivi Saravanan, Shana Burrowes, Lindsay Demers.

Session L- Channel 3 Friday 11/6 10:30 am-12:00 pm

50 SUBTYPING OF HNSCC SINGLE-CELL RNA-SEQ IDENTIFIES TRANSCRIPTIONAL PROGRAMS CHARACTERIZED BY SUPPRESSION OF MTORC1 AND WNT SIGNALING PATHWAYS AND BETTER PATIENT PROGNOSIS

Eric Reed.

180 TRENDS IN HOSPITALIZATIONS FOR SERIOUS INFECTIONS IN PATIENTS WITH SPONDYLOARTHRITIS AS COMPARED TO RHEUMATOID ARTHRITIS USING THE NATIONAL INPATIENT SAMPLE 2007-2014

Vagishwari Murugesan, Eleni Pilitsi, Maureen Dubreuil.

53 LIFE-SPACE AS AN INDICATOR OF ACTIVE MOBILITY IN PERSONS WITH PARKINSON DISEASE.

Jenna Zajac, James Cavanaugh, Terry Ellis.

191 PILOT OF AN EMBEDDED IMMIGRATION ATTORNEY WITHIN BMC’S IMMIGRANT AND REFUGEE HEALTH CENTER

Houda Chergui, Claire Oppenheim, Sarem Rashid, Molly Zhao, Jason Maniscalco, Sarah Kimball.

21 RACE & ETHNICITY IN AL AMYLOIDOSIS

Andrew Staron, Lawreen Connors, Luke Zheng, Gheorghe Doros, Vaishali Sanchorawala.

126 THE EFFECTS OF JUUL AND COMBUSTIBLE CIGARETTE USE ON INDICES OF HEART RATE VARIABILITY

Chelsea Akubo, Sana Majid, Jessica Fetterman, Robert Weisbrod, Comreen Vargees, Bihua Feng, Shamsh Sheikh, Destinee Bledsoe, Rachel Keith, Naomi Hamburg.

187 RACIAL DISPARITIES IN GENETIC TESTING FOR BREAST CANCER PATIENTS

Jihoon Choi, Tsion Fikre, Naomi Ko.

63 ACUTE JUUL USE IS ASSOCIATED WITH ALTERED VASCULAR FUNCTION AND BLOOD PRESSURE

Sana Majid, Rachel Keith, Jessica Fetterman, Robert Weisbrod, Naomi Hamburg.

194 IMPAIRED OXYGEN UPTAKE EFFICIENCY SLOPE PREDICTS MORTALITY IN WILD-TYPE TRANSTHYRETIN AMYLOID CARDIOMYOPATHY

Michael Fattouh, Akash Patel, Amir Gilad, Brian Smerkers, Anam Waheed, John Berk, Lawreen Connors, Vaishali Sanchorawala, Omar Siddiqi, Frederick Ruberg, Gary Balady, Deepa Gopal.

164 DETECTION OF DEMENTIA FROM RAW VOICE RECORDINGS USING RECURRENT NEURAL NETWORK

Chonghua Xue, Cody Karjadi, Rhoda Au, Vijaya Kolachalama.