Shakun Karki, PhD
Assistant Professor, Medicine
Biography
Obesity represents the largest preventable health care problem in the United States. More than two third of deaths related to obesity worldwide are from cardiovascular cause. Pathological mechanisms that connect obesity with cardiovascular are incompletely understood. Dr. Karki’s research interests focuses on understanding the mechanisms of obesity induced diseases, including endothelial and vascular dysfunction, insulin-resistance and cardiovascular disease.
Other Positions
- Member, Whitaker Cardiovascular Institute, Boston University
Education
- Boston University School of Medicine, PhD
- University of New Hampshire, MS
Publications
- Published on 1/28/2021
Mazzotta C, Basu S, Gower AC, Karki S, Farb MG, Sroczynski E, Zizza E, Sarhan A, Pande AN, Walsh K, Dobrilovic N, Gokce N. Perivascular Adipose Tissue Inflammation in Ischemic Heart Disease. Arterioscler Thromb Vasc Biol. 2021 03; 41(3):1239-1250. PMID: 33504180.
Read at: PubMed - Published on 9/1/2019
Karki S. FSP27 and Links to Obesity and Diabetes Mellitus. Curr Obes Rep. 2019 Sep; 8(3):255-261. PMID: 30919313.
Read at: PubMed - Published on 6/1/2019
Karki S, Farb MG, Sharma VM, Jash S, Zizza EJ, Hess DT, Carmine B, Carter CO, Pernar LI, Apovian CM, Puri V, Gokce N. Fat-Specific Protein 27 Regulation of Vascular Function in Human Obesity. J Am Heart Assoc. 2019 06 04; 8(11):e011431. PMID: 31433737.
Read at: PubMed - Published on 5/31/2019
Frenquelli M, Caridi N, Antonini E, Storti F, Viganò V, Gaviraghi M, Occhionorelli M, Bianchessi S, Bongiovanni L, Spinelli A, Marcatti M, Belloni D, Ferrero E, Karki S, Brambilla P, Martinelli-Boneschi F, Colla S, Ponzoni M, DePinho RA, Tonon G. The WNT receptor ROR2 drives the interaction of multiple myeloma cells with the microenvironment through AKT activation. Leukemia. 2020 01; 34(1):257-270. PMID: 31148590.
Read at: PubMed - Published on 12/21/2018
Ngo DTM, Sverdlov AL, Karki S, Macartney-Coxson D, Stubbs RS, Farb MG, Carmine B, Hess DT, Colucci WS, Gokce N. Oxidative modifications of mitochondrial complex II are associated with insulin resistance of visceral fat in obesity. Am J Physiol Endocrinol Metab. 2019 02 01; 316(2):E168-E177. PMID: 30576243.
Read at: PubMed - Published on 12/11/2017
Zuriaga MA, Fuster JJ, Farb MG, MacLauchlan S, Bretón-Romero R, Karki S, Hess DT, Apovian CM, Hamburg NM, Gokce N, Walsh K. Activation of non-canonical WNT signaling in human visceral adipose tissue contributes to local and systemic inflammation. Sci Rep. 2017 12 11; 7(1):17326. PMID: 29229927.
Read at: PubMed - Published on 9/29/2017
Farb MG, Park SY, Karki S, Gokce N. Assessment of Human Adipose Tissue Microvascular Function Using Videomicroscopy. J Vis Exp. 2017 Sep 29; (127). PMID: 28994775.
Read at: PubMed - Published on 4/14/2017
Karki S, Ngo DTM, Farb MG, Park SY, Saggese SM, Hamburg NM, Carmine B, Hess DT, Walsh K, Gokce N. WNT5A regulates adipose tissue angiogenesis via antiangiogenic VEGF-A165b in obese humans. Am J Physiol Heart Circ Physiol. 2017 Jul 01; 313(1):H200-H206. PMID: 28411232.
Read at: PubMed - Published on 9/28/2016
Farb MG, Karki S, Park SY, Saggese SM, Carmine B, Hess DT, Apovian C, Fetterman JL, Bretón-Romero R, Hamburg NM, Fuster JJ, Zuriaga MA, Walsh K, Gokce N. WNT5A-JNK regulation of vascular insulin resistance in human obesity. Vasc Med. 2016 Dec; 21(6):489-496. PMID: 27688298.
Read at: PubMed - Published on 11/18/2015
Karki S, Farb MG, Myers S, Apovian C, Hess DT, Gokce N. Effect of Bariatric Weight Loss on the Adipose Lipolytic Transcriptome in Obese Humans. Mediators Inflamm. 2015; 2015:106237. PMID: 26663986.
Read at: PubMed
View 10 more publications: View full profile at BUMC