Tsuneya Ikezu, MD, PhD

Adjunct Professor, Boston University Chobanian & Avedisian School of Medicine

Biography

My expertise is biomedical research on neurodegenerative disorders, neuroinflammation, and molecular pharmacologic interventions. Specifically, I have been studying the therapeutic potentials of select anti-inflammatory and neurotrophic factors on animal models of Alzheimer's disease and frontotemporal dementia using virus-mediated gene delivery system. The virus systems include adeno-associated virus, adenovirus, and lentivirus. I have also been investigating the role of innate immunity, more specifically the functions of macrophages and microglia, on HIV-1 infection and neuroinflammation in the context of HIV-associated neurocognitive dysfunction and Alzheimer's disease.

Publications

  • Published 2/20/2026

    Delpech JC, Kalavai SV, Pathak D, Ravula AR, Lad HV, Hays EC, Touch N, Rau A, Madore C, Medalla M, Luebke JI, Ikezu S, Ikezu T. Entorhinal Cortex Wolframin-1-expressing neurons propagate tau to CA1 neurons and impair hippocampal memory. bioRxiv. 2026 Feb 20. PMID: 41757076.

    Read at: PubMed

  • Published 11/2/2025

    Delpech JC, Yeh H, Kalavai SV, You Y, Ruan Z, Touch N, Hersh S, Monguillon P, Johnson WE, Rau A, Madore C, Ikezu T, Ikezu S. Sex specific correction of maternal inflammation-induced behavioral abnormalities by the inhibition of colony-stimulating factor 1 receptor. Brain Behav Immun. 2026 Jan; 131:106163. PMID: 41187794.

    Read at: PubMed

  • Published 11/1/2025

    Crescitelli R, Huang Y, Hendrix A, Hill AF, Hurwitz SN, Ikezu T, Levy E, Puig B, Paolini L, Vella LJ. Recommendations for Studying In Situ Extracellular Vesicles From Solid Tissue. J Extracell Vesicles. 2025 Nov; 14(11):e70185. PMID: 41220186.

    Read at: PubMed

  • Published 10/23/2025

    Gibbs BJ, Chen Y, Abdullah M, Nguyen S, McQuaker-Kajiwara J, Melvin B, Longtree-Preciado A, Liang Z, Gonzalez-Perez MP, Ikezu S, Ikezu T. Proteomic characterization of neuronal extracellular vesicle interactomes in Alzheimer's disease mouse model through TurboID-based proximity labeling. bioRxiv. 2025 Oct 23. PMID: 41278630.

    Read at: PubMed

  • Published 6/23/2025

    Ikezu T, Bodart-Santos V, Ravula AR, You Y, Abdullah M, Ruan Z, Ellison J, Radhakishun S, Ray NB, Melvin B, Kurti A, Liang Z, Sakai Y, O'Brien D, Nguyen S, Shaffer S, Fiddes L, Butovsky O, Springer W, Ikezu S. P2RX7 regulates tauopathy progression via tau and mitochondria loading in extracellular vesicles. Res Sq. 2025 Jun 23. PMID: 40678243.

    Read at: PubMed

View All 152 Publications:   View Full Profile in BUMC

Other Positions

  • Professor, Neurology
    Boston University Chobanian & Avedisian School of Medicine
  • Member, Evans Center for Interdisciplinary Biomedical Research
    Boston University
  • Graduate Medical Sciences Educator and Mentor (Primary Mentor of Graduate Students)
    Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

Websites

Education

  • Tokyo Medical and Dental University, MD
  • Tokyo Medical and Dental University, PhD
  • University of Tokyo, BS

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