Dr. Haydar received his doctorate at the University of Maryland School of Medicine working on brain development in the Trisomy 16 mouse model of Down syndrome with Dr. Bruce Krueger. He completed postdoctoral studies at Yale University with Dr. Pasko Rakic examining control of forebrain neural precursor development and then started his independent laboratory at Children’s National Medical Center in Washington, DC in 2002. Dr. Haydar joined the Anatomy & Neurobiology Department at BUSM in 2010 where he maintains a vibrant laboratory using state-of-the-art molecular and surgical techniques to study mammalian brain development. Using in utero electroporation, in vivo genetic fate mapping and cell ablation techniques, this project is focused on how the multiple populations of neural stem cells and progenitor cells in the embryonic brain are lineally related and how their combined output leads to proper forebrain development. In addition, the lab is focusing on brain development and function in trisomy mouse models of Down syndrome using cellular, molecular and behavioral techniques. Dr. Haydar’s research is funded by the NIH (NINDS and NICHD).
- Faculty, National Emerging Infectious Disease Lab, Boston University
- Member, Genome Science Institute, Boston University
- Graduate Faculty (Primary Mentor of Grad Students), Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences
- University of Maryland School of Medicine, PhD
- University of Massachusetts Amherst, BS
- Published on 9/7/2022
Li Z, Klein JA, Rampam S, Kurzion R, Campbell NB, Patel Y, Haydar TF, Zeldich E. Asynchronous excitatory neuron development in an isogenic cortical spheroid model of Down syndrome. Front Neurosci. 2022; 16:932384. PMID: 36161168.
- Published on 8/15/2022
Jablonska B, Adams KL, Kratimenos P, Li Z, Strickland E, Haydar TF, Kusch K, Nave KA, Gallo V. Sirt2 promotes white matter oligodendrogenesis during development and in models of neonatal hypoxia. Nat Commun. 2022 Aug 15; 13(1):4771. PMID: 35970992.
- Published on 7/15/2022
Klein JA, Haydar TF. Neurodevelopment in Down syndrome: Concordance in humans and models. Front Cell Neurosci. 2022; 16:941855. PMID: 35910249.
- Published on 1/4/2022
Klein JA, Li Z, Rampam S, Cardini J, Ayoub A, Shaw P, Rachubinski AL, Espinosa JM, Zeldich E, Haydar TF. Sonic Hedgehog Pathway Modulation Normalizes Expression of Olig2 in Rostrally Patterned NPCs With Trisomy 21. Front Cell Neurosci. 2021; 15:794675. PMID: 35058753.
- Published on 9/9/2021
Shelton SM, Soucy AR, Kurzion R, Zeldich E, Connor JH, Haydar TF. Forebrain Neural Precursor Cells Are Differentially Vulnerable to Zika Virus Infection. eNeuro. 2021 Sep-Oct; 8(5). PMID: 34272257.
- Published on 5/20/2021
Dierssen M, Herault Y, Helguera P, Martínez de Lagran M, Vazquez A, Christian B, Carmona-Iragui M, Wiseman F, Mobley W, Fisher EMC, Brault V, Esbensen A, Jacola LM, Potier MC, Hamlett ED, Abbeduto L, Del Hoyo Soriano L, Busciglio J, Iulita MF, Crispino J, Malinge S, Barone E, Perluigi M, Costanzo F, Delabar JM, Bartesaghi R, Dekker AD, De Deyn P, Fortea Ormaechea J, Shaw PA, Haydar TF, Sherman SL, Strydom A, Bhattacharyya A. Building the Future Therapies for Down Syndrome: The Third International Conference of the T21 Research Society. Mol Syndromol. 2021 Jul; 12(4):202-218. PMID: 34421499.
- Published on 12/9/2020
Shaw PR, Haydar TF. Mitigating Cognitive Deficits in Down Syndrome by Managing Microglia Activation. Neuron. 2020 12 09; 108(5):799-800. PMID: 33301721.
- Published on 11/6/2020
Li Z, Tyler WA, Zeldich E, Santpere Baró G, Okamoto M, Gao T, Li M, Sestan N, Haydar TF. Transcriptional priming as a conserved mechanism of lineage diversification in the developing mouse and human neocortex. Sci Adv. 2020 11; 6(45). PMID: 33158872.
- Published on 9/25/2020
Shaw PR, Klein JA, Aziz NM, Haydar TF. Longitudinal neuroanatomical and behavioral analyses show phenotypic drift and variability in the Ts65Dn mouse model of Down syndrome. Dis Model Mech. 2020 09 25; 13(9). PMID: 32817053.
- Published on 7/14/2020
Li Z, Tyler WA, Haydar TF. Lessons from single cell sequencing in CNS cell specification and function. Curr Opin Genet Dev. 2020 12; 65:138-143. PMID: 32679535.
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