Tarik F. Haydar, Ph.D.

haydarAssociate Professor

Phone: 617-638-4249
Lab: 617-84209, Room L-813
Fax: 617-638-4252
Email: thaydar@bu.edu

Laboratory of Neural Development and Intellectual Disorders

Dr. Haydar received his doctorate at the University of Maryland School of Medicine working on brain development in the Trisomy 16 mouse model of Down syndrome with Dr. Bruce Krueger. He completed postdoctoral studies at Yale University with Dr. Pasko Rakic examining control of forebrain neural precursor development and then started his independent laboratory at Children’s National Medical Center in Washington, DC in 2002. Dr. Haydar joined the Anatomy & Neurobiology Department at BUSM in 2010 where he maintains a vibrant laboratory using state-of-the-art molecular and surgical techniques to study mammalian brain development. Using in utero electroporation, in vivo genetic fate mapping and cell ablation techniques, this project is focused on how the multiple populations of neural stem cells and progenitor cells in the embryonic brain are lineally related and how their combined output leads to proper forebrain development. In addition, the lab is focusing on brain development and function in trisomy mouse models of Down syndrome using cellular, molecular and behavioral techniques. Dr. Haydar’s research is funded by the NIH (NINDS and NICHD).

Recent publications:

Chakrabarti, L., Best, T.K., Cramer, N.P., Carney, R.S.E., Issac, J.T.R., Galdzicki, Z., and Haydar, T.F. (2010) Olig1 and Olig2 triplication causes developmental brain defects in Down syndrome. Nature Neuroscience,13(8):927-34.

Stancik, E., Navarro, I., Sellke. R., and Haydar, T.F. (2010) Heterogeneity of neural precursors in the mammalian ventricular zone generates neuronal diversity during neocortical development. Journal of Neuroscience, 30(20):7028-36.

Bruenig, J.J., Haydar, T.F. and Rakic, P. (2011) Neural Stem Cells: Historical perspective and future prospects. Neuron, doi:10.1016/j.neuron.2011.05.005.

Best, T.K., Cramer, N.P., Chakrabarti, L., Haydar, T.F. and Galdzicki, Z. (2012) Dysfunctional hippocampal inhibition in the Ts65Dn mouse model of Down syndrome. Exp. Neurol., 233(2):749-57.

Haydar, T.F. and Reeves, R.R. (2012) Trisomy 21 and early brain development. Trends Neurosciences, 35(2):81-91.

Tyler, W.A. and Haydar, T.F. (2013) Multiplex genetic fate mapping reveals a novel route of neocortical neurogenesis, which is altered in the Ts65Dn mouse model of Down syndrome. Journal of Neuroscience, 33(12):5106-5119.

Tyler, WA, Medalla, M., Guillamon-Vivancos, T., Luebke, J.I. and Haydar, T.F. (2015) Neural precursor lineages specify distinct neocortical pyramidal neuron types. Journal of Neuroscience, in press.