Tarik F. Haydar, Ph.D.
Lab: 617-84209, Room L-813
Laboratory of Neural Development and Intellectual Disorders
Dr. Haydar received his doctorate at the University of Maryland School of Medicine working on brain development in the Trisomy 16 mouse model of Down syndrome with Dr. Bruce Krueger. He completed postdoctoral studies at Yale University with Dr. Pasko Rakic examining control of forebrain neural precursor development and then started his independent laboratory at Children’s National Medical Center in Washington, DC in 2002. Dr. Haydar joined the Anatomy & Neurobiology Department at BUSM in 2010 where he maintains a vibrant laboratory using state-of-the-art molecular and surgical techniques to study mammalian brain development. Using in utero electroporation, in vivo genetic fate mapping and cell ablation techniques, this project is focused on how the multiple populations of neural stem cells and progenitor cells in the embryonic brain are lineally related and how their combined output leads to proper forebrain development. In addition, the lab is focusing on brain development and function in trisomy mouse models of Down syndrome using cellular, molecular and behavioral techniques. Dr. Haydar’s research is funded by the NIH (NINDS and NICHD).
Haydar, T.F. (2005) Advanced microscopic imaging methods to investigate cortical development and the etiology of mental retardation, Ment. Retard. Dev. Disab. Reviews, 11: 303-316.
Liu, X., Wang, Q., Haydar, T.F., and Bordey, A. (2005) Nonsynaptic GABAergic signaling in the postnatal subventricular zone controls astrocyte-like cell proliferation, Nature Neuroscience 8(9): 1179-1187.
Gal, J.S., Morozov, Y.M., Ayoub, A.E., Chatterjee, M., Rakic, P., and Haydar, T.F. (2006) Molecular and morphological heterogeneity of neural precursors in the mouse neocortical proliferative zones. Journal of Neuroscience, 26(3): 1045-1056.
Harashima, C., Jacobowitz, J.M., Stoffel, M., Haydar, T.F., Chakrabarti, L., Siarey, R., Galdzicki, Z. (2006) Elevated expression of the G-Protein activated inwardly rectifying potassium channel 2 (GIRK2) in Cerebellar Unipolar Brush Cells of Down Syndrome Mouse Model. Cell. Mol. Neurobiol. Jun 17 [Epub ahead of print].
Navarro-Quiroga, I., Chittajallu, R., Gallo, V., and Haydar, T.F. (2007) Long-term, selective gene expression in developing and adult hippocampal pyramidal neurons using focal in utero electroporation. Journal of Neuroscience, 27(19): 5007-5011.
Slotkin, J.R.*, Chakrabarti, L.*, Dai, H-N., Gallicano, G.I., Carney, R.S.E., Bregman, B.S., Corbin, J.G., and Haydar, T.F. (2007) In vivo quantum dot labeling of mammalian neural stem cells. Developmental Dynamics, Jul 11 [Epub ahead of print]. *These authors contributed equally.
Chakrabarti, L., Galdzicki, Z., and Haydar, T.F. (2007) Defects in embryonic neurogenesis and initial synapse formation in the forebrain of the Ts65Dn mouse model of Down syndrome. Journal of Neuroscience, 27(43): 11483-95.
Corbin, J.G., Gaiano, N., Juliano, S.L., Stancik, E., and Haydar, T.F. (2008) Regulation of neural progenitor cell development in the nervous system. Journal of Neurochemistry, 106(6): 2272-87.
Liu, X., Hashimoto-Torii, K., Haydar, T.F., and Rakic, P. (2008) The role of ATP signaling in the migration of intermediate neuronal progenitors to the neocortical subventricular zone. PNAS USA, 105(33):11802-7.
Loulier, K., Lathia, J.D., Martiens, V., Relucio, J., Mughal, M.R., Tang, S-C., Coksaygan, T., Hall, P.E., Chigurupati, S., Patton, B., Colognato, H., Rao, M.S., Mattson, M.P., Haydar, T.F.*, and ffrench-Constant, C*. (2009) Laminin-binding integrins are essential for anchorage of neocortical neural stem cells to the ventricular surface. *Co-corresponding authors, PLoS Biology, Aug;7(8):e1000176. Epub 2009 Aug 18.
Gadea, A., Aguirre, A.A., Haydar, T.F., and Gallo, V. (2009) A novel role for endothelin 1 as a regulator of oligodendrocyte development. Journal of Neuroscience, 29(32):10047-62. PMCID: 2754292.
Chakrabarti, L., Best, T.K., Cramer, N.P., Carney, R.S.E., Issac, J.T.R., Galdzicki, Z., and Haydar, T.F. (2010) Olig1 and Olig2 triplication causes developmental brain defects in Down syndrome. Nature Neuroscience,13(8):927-34.
Stancik, E., Navarro, I., and Haydar, T.F. (2010) Heterogeneity of neural precursors in the mammalian ventricular zone generates neuronal diversity during neocortical development. Journal of Neuroscience, 30(20):7028-36.
Tyler, W.A. and Haydar, T.F. (2010) A new contribution to brain convolution: progenitor cell logistics during cortex development. Nature Neuroscience, 13(6):656-7.