Stefano Monti, PhD
Associate Professor, Medicine
Biography
Stefano Monti is a Computational Biologist and joined the BU faculty in January 2011 in the section of Computational Biomedicine, with joint appointments in the Biostatistics Department and the Bioinformatics program. Monti received his Ph.D. in Intelligent Systems and Artificial Intelligence from the University of Pittsburgh, and completed his training with a post-doctoral fellowship at the Robotics Institute at Carnegie Mellon. His doctoral and post-doctoral research focused on the development of machine learning and knowledge discovery methodologies, with a particular emphasis on probabilistic reasoning and Bayesian approaches to modeling biomedical data. Since 2001, he has worked in the field of Cancer Genomics, first as a Research Scientist at the Whitehead Institute’s Center for Genome Research, and later as a Computational Biologist in the Cancer Program at the Broad Institute.
Dr. Monti’s laboratory integrates systems biology, machine learning, and bioinformatics approaches to investigate the molecular drivers of human disease, with the goals of advancing prevention and care. This multidisciplinary effort relies on the development of novel computational methodologies, and on the design of experiments based on the generation and integrative analysis of high-throughput multi-omics data, with the goal of identifying novel therapeutic targets and developing accurate diagnostic and prognostic biomarkers. Specific areas of research include the study of the molecular mechanisms of tumor initiation and progression and of the role played in it by environmental exposure, as well as the study of the biological factors contributing to healthy aging and extreme longevity.
Other Positions
- Associate Professor, Biostatistics, Boston University School of Public Health
- Member, BU-BMC Cancer Center, Boston University
- Member, Evans Center for Interdisciplinary Biomedical Research, Boston University
- Member, Bioinformatics Graduate Program, Boston University
- Member, Genome Science Institute, Boston University
- Graduate Faculty (Primary Mentor of Grad Students), Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences
Education
- University of Pittsburgh, PhD
- University of Pittsburgh, MS
- University of Houston, MS
- Università degli Studi di Udine, BS
Classes Taught
- ENGBF900
- ENGBF901
- SPHBS831
Publications
- Published on 8/27/2023
Leshchyk A, Xiang Q, Andersen SL, Gurinovich A, Song Z, Lee JH, Christensen K, Yashin A, Wojczynski M, Schwander K, Perls TT, Monti S, Sebastiani P. Mosaic Chromosomal Alterations and Human Longevity. J Gerontol A Biol Sci Med Sci. 2023 Aug 27; 78(9):1561-1568. PMID: 36988570.
Read at: PubMed - Published on 8/4/2023
Khan MM, Frustino J, Villa A, Nguyen BC, Woo SB, Johnson WE, Varelas X, Kukuruzinska M, Monti S. Total RNA sequencing reveals gene expression and microbial alterations shared by oral pre-malignant lesions and cancer. Hum Genomics. 2023 Aug 04; 17(1):72. PMID: 37542347.
Read at: PubMed - Published on 6/21/2023
Reed ER, Jankowski SA, Spinella AJ, Noonan V, Haddad R, Nomoto K, Matsui J, Bais MV, Varelas X, Kukuruzinska MA, Monti S. ß-catenin/CBP activation of mTORC1 signaling promotes partial epithelial-mesenchymal states in head and neck cancer. Transl Res. 2023 Oct; 260:46-60. PMID: 37353110.
Read at: PubMed - Published on 6/1/2023
Karagiannis TT, Monti S, Sebastiani P. Bayesian differential analysis of cell type proportions: opinion. Front Genet. 2023; 14:1205499. PMID: 37323674.
Read at: PubMed - Published on 5/18/2023
Federico A, Kern J, Varelas X, Monti S. Structure learning for gene regulatory networks. PLoS Comput Biol. 2023 May; 19(5):e1011118. PMID: 37200395.
Read at: PubMed - Published on 3/31/2023
Karagiannis TT, Dowrey TW, Villacorta-Martin C, Montano M, Reed E, Belkina AC, Andersen SL, Perls TT, Monti S, Murphy GJ, Sebastiani P. Multi-modal profiling of peripheral blood cells across the human lifespan reveals distinct immune cell signatures of aging and longevity. EBioMedicine. 2023 Apr; 90:104514. PMID: 37005201.
Read at: PubMed - Published on 3/29/2023
Leshchyk A, Xiang Q, Andersen SL, Gurinovich A, Song Z, Lee JH, Christensen K, Yashin A, Wojczynski M, Schwander K, Perls TT, Monti S, Sebastiani P. Mosaic chromosomal alterations and human longevity. J Gerontol A Biol Sci Med Sci. 2023 Mar 29. PMID: 36988570.
Read at: PubMed - Published on 3/24/2023
Khan MM, Frustino J, Villa A, Nguyen BC, Woo SB, Johnson WE, Varelas X, Kukuruzinska M, Monti S. Total RNA sequencing reveals gene expression and microbial alterations shared by oral pre-malignant lesions and cancer. bioRxiv. 2023 Mar 24. PMID: 36993637.
Read at: PubMed - Published on 1/19/2023
Karagiannis TT, Monti S, Sebastiani P. Bayesian Differential Analysis of Cell Type Proportions. bioRxiv. 2023 Jan 19. PMID: 36712131.
Read at: PubMed - Published on 11/28/2022
Kern JG, Tilston-Lunel AM, Federico A, Ning B, Mueller A, Peppler GB, Stampouloglou E, Cheng N, Johnson RL, Lenburg ME, Beane JE, Monti S, Varelas X. Inactivation of LATS1/2 drives luminal-basal plasticity to initiate basal-like mammary carcinomas. Nat Commun. 2022 Nov 28; 13(1):7198. PMID: 36443313.
Read at: PubMed
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