Stefano Monti, PhD

Professor, Boston University Chobanian & Avedisian School of Medicine

Biography

Stefano Monti is a Computational Biologist and joined the BU faculty in January 2011 in the section of Computational Biomedicine, with joint appointments in the Biostatistics Department and the Bioinformatics program. Monti received his Ph.D. in Intelligent Systems and Artificial Intelligence from the University of Pittsburgh, and completed his training with a post-doctoral fellowship at the Robotics Institute at Carnegie Mellon. His doctoral and post-doctoral research focused on the development of machine learning and knowledge discovery methodologies, with a particular emphasis on probabilistic reasoning and Bayesian approaches to modeling biomedical data. Since 2001, he has worked in the field of Cancer Genomics, first as a Research Scientist at the Whitehead Institute’s Center for Genome Research, and later as a Computational Biologist in the Cancer Program at the Broad Institute.

Dr. Monti's laboratory integrates systems biology, machine learning, and bioinformatics approaches to investigate the molecular drivers of human disease, with the goals of advancing prevention and care. This multidisciplinary effort relies on the development of novel computational methodologies, and on the design of experiments based on the generation and integrative analysis of high-throughput multi-omics data, with the goal of identifying novel therapeutic targets and developing accurate diagnostic and prognostic biomarkers. Specific areas of research include the study of the molecular mechanisms of tumor initiation and progression and of the role played in it by environmental exposure, as well as the study of the biological factors contributing to healthy aging and extreme longevity.

Publications

  • Published 5/3/2025

    Chen AD, Kroehling L, Ennis C, Denis GV, Monti S. A highly resolved integrated transcriptomic atlas of human breast cancers. bioRxiv. 2025 May 03. PMID: 40161579.

    Read at: PubMed

  • Published 4/7/2025

    Rogina B, Anderson R, LeBrasseur NK, Curran SP, Yousefzadeh MJ, Ghosh B, Duque G, Howlett S, Austad S, Demuth I, Gerstorf D, Korfhage J, Lombard DB, Abadir P, Christensen K, Carey JR, Alberts SC, Campos F, Palavicini JP, Palmer A, Bell J, Basisty N, de Cabo R, Gomes A, Dixit VD, Sen P, Baur JA, Imai SI, Li X, Valdez G, Orr ME, Pletcher S, Andersen J, Jones L, Castillo-Azofeida D, Bonaguidi M, Suh Y, Duncan FE, Murray A, Wang MC, Burkewitz K, Henne M, Zhou K, Bouhrara M, Benjamini D, Kolind S, Walker KA, Reiter DA, Dean DC, Gorbunova V, Gladyshev VN, Palovics R, Niedernhofer LJ, Fan R, Bueckle AD, Hurley J, Esser KA, Kapahi P, Sato S, Jiang N, Ashiqueali SA, Diaz J, Mishra SP, Raimundo N, Banarjee R, Allsopp R, Reynolds LM, Zhang B, Sebastiani P, Monti S, Schork N, Rappaport N. Symposia Report of The Annual Biological Sciences Section Meeting of the Gerontological Society of America 2023, Tampa, Florida. J Gerontol A Biol Sci Med Sci. 2025 Apr 07; 80(5). PMID: 39932386.

    Read at: PubMed

  • Published 3/17/2025

    Chakraborty AK, Kroehling L, Raut RD, Choudhury C, Kukuruzinska M, Gutkind JS, Varelas X, Sahay B, Monti S, Bais MV. LSD1 inhibition corrects dysregulated MHC-I and dendritic cells activation through IFN?-CXCL9-CXCR3 axis to promote antitumor immunity in HNSCC. bioRxiv. 2025 Mar 17. PMID: 40166238.

    Read at: PubMed

  • Published 3/6/2025

    Qiu Y, Chen A, Yu R, Llevenes P, Seen M, Ko NY, Monti S, Denis GV. Insulin Resistance Increases TNBC Aggressiveness and Brain Metastasis via Adipocyte-derived Exosomes. Mol Cancer Res. 2025 Mar 06. PMID: 40047645.

    Read at: PubMed

  • Published 3/4/2025

    Kroehling L, Chen A, Spinella A, Reed E, Kukuruzinka M, Varelas X, Monti S. A highly resolved integrated single-cell atlas of HPV-negative head and neck cancer. bioRxiv. 2025 Mar 04. PMID: 40093171.

    Read at: PubMed

View All 152 Publications:   View Full Profile in BUMC

Other Positions

  • Associate Professor, Biostatistics
    Boston University School of Public Health
  • Member, BU-BMC Cancer Center
    Boston University
  • Member, Evans Center for Interdisciplinary Biomedical Research
    Boston University
  • Member, Bioinformatics Graduate Program
    Boston University
  • Member, Genome Science Institute
    Boston University
  • Graduate Faculty (Primary Mentor of Grad Students)
    Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

Websites

Education

  • University of Pittsburgh, PhD
  • University of Pittsburgh, MS
  • University of Houston, MS
  • Università degli Studi di Udine, BS

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